Endocrine Abstracts (2009) 20 P431

Serum homocysteine levels in diabetes and its relationship to nephropathy

Mozhgan Afkhamizadeh, Hosein Ayatollahi, Majid Abrishami, Zohreh Musavi, Shokufeh Bonakdaran, Robab Aboutorabi & Mohammad Khajeh Dalouei


Mashhad University of Medical Science, Mashhad, Khorasan Razavi, Islamic Republic of Iran.


Introduction: Diabetes is a common disease with many complications; therefore many researches are done on possible factors witch affect on diabetes control and its complications. Homocysteine is one of these possible factors. We studied correlation of homocysteine and diabetes. We also compared homocysteine levels in diabetic patients with nephropathy and patients without nephropathy.

Materials and methods: Of 105 diabetic patients and 32 controls were enrolled in study. Smokers, addicts, pregnant women, patients with macrocytic anemia, thyroid disease and renal failure were excluded. Only patients with type 2 diabetes were studied. Serum homocysteine, FBS, creatinin and urine microalbumin and creatinin were measured.

Results: The patients and controls were matched in age, sex, hypertension, BMI and family history of diabetes. There was no significant difference in homocysteine between patients and control. Homocysteine level in diabetic patients was 12.9±9.5 μmol/l and 11.6±8.6 μmol/l in control group. Also there wasn’t any significant difference between diabetic patients with and without nephropathy in homocysteine level. Serum homocysteine was 13.2±11.08 μmol/l in patients with nephropathy and 12.5±9 μmol/l in patients without nephropathy (P=0.9).

Conclusion: In contrast to most of other studies, our study showed no difference in homocysteine between diabetics and control. This may be due to number of cases or racial difference.

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