Endocrine Abstracts (2009) 20 P478

Relationship between prehypertension and metabolic risk markers in over weight and obese women

Faruk Kutluturk1, Taner Bayraktaroglu2, Adil Azezli2 & Yusuf Orhan2

1Division of Endocrinology and Metabolism, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey; 2Division of Endocrinology and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Introduction: Hypertension is a major risk factor for several cardiovascular diseases including coronary heart disease. Prehypertension is defined systolic blood pressure (SBP) between 120–139 mmHg and diastolic blood pressure (DBP) 80–89 mmHg. Recent studies have documented an increased risk of cardiovascular disease in persons with prehypertension. In this study, we evaluated association between prehypertension and the metabolic risk markers in over weight and obese women.

Methods: Overweight (25<BMI<30 kg/m2) 824, and obese (BMI(30 kg/m2) 2652 women were enrolled into the study. The subjects were divided into two groups: Group 1 (n=1131); women with blood pressure <120/80 mmHg; normal group, Group 2 (n=2345); women with 120<SBP<139 mmHg, and 80<DBP<89 mmHg; prehypertension group. The groups were compared for metabolic risk markers regards of cardiovascular disease.

Results: BMI, waist, sagital waist, body fat, intra-abdominal fat, HgA1c, fasting insulin, HOMA, triglyceride, cholesterol, LDL-C were significantly higher prehypertension group compared to normal subjects (P<0.001). The results are documented on Table.

Conclusion: This study demonstrated that prehypertension was associated with metabolic risk markers in over weight and obese women.It is known that prehypertension is associated with atherosclerosis, including increased coronary atherosclerosis, elevated C-reactive protein, tumor necrosis factor, homocysteine, oxidized LDL, and other inflammatory markers. Successful management can reasonably be expected to reduce CVD morbidity and mortality.

Table Comparison of the groups for metabolic risk markers.
Group 1 (n=1131)Group 2 (n=2345)P value
Age (years)35.74±11.1438.24±11.58<0.001
Weight (kg)84.16±14.6987.96±15.85<0.001
BMI (kg/m2)33.58±5.7735.19±6.29<0.001
Body fat (kg)39.25±15.7543.64±17.59<0.001
Waist (cm)96.64±22.0098.99±12.69<0.001
Saggital waist (cm)23.71±3.6424.55±3.91<0.001
Intra-abdominal fat (L)3.13±1.073.38±1.16<0.001
Cholesterol (mg/dl)193.70±40.53201.74±40.92<0.001
LDL (mg/dl)120.98±34.08126.21±35.86<0.001
HDL (mg/dl)47.99±11.5347.85±11.39NS
Triglyceride (mg/dl)124.59±80.03141.15±100.05<0.001
Glucose (mg/dl)92.89±18.4496.61±27.40<0.001
HbA1c (%)5.63±0.615.71±0.810.041
Insulin (uIU/l)11.90±11.3913.59±12.41<0.001

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