Endocrine Abstracts (2009) 20 P487

Insulin resistance and anemia markers

Süheyla Görar, Cavit Çulha, Y Selim Demir, Rüstü Serter & Yalcin Aral


Endocrinology and Metabolic Disease Department, Ankara Education and Research Hospital, Ankara, Turkey.


Aim: In our study, in regard with the women cases of obesity, we have aimed at determining the correlation that existed among the anemia markers, insulin resistance (IR) and fact of Metabolic syndrome (MetS).

Method: We have conducted our assessment 67 women who had resorted to our clinic due to their obesity complaints and were in the premenopausal and mean age 36.7±8.8 years. We have put forward the demographic data and measured the biochemical (fasting and postprandial blood glucose, uric acid, insulin, lipid profile, leptin, visfatin, hCRP) and hematologic (hemogram, ferritine, folate, vitamin B12) parameters. Such cases were included in three different groups; HOMA-IR>2.2 and HOMA-IR<2.2 and BMI of overweight-obese-morbid obese and whether or not a diagnosis, was established as MetS.

Results: The correlation analysis which was performed on whole group served to indicate that ferritine had a correlation with factors such as weight, fat%, leptin, visfatin, h-CRP. In the grouping process which was performed according to HOMA-IR, weight, waist circumference, fat%, fasting-postprandial glucose, triglyceride were found significantly high in the HOMA-IR>2.2. In the grouping process which was performed according to obese-morbid obese systolic blood pressure(SBP) and h-CRP were found significantly in favor of morbid obese group. The comparison of persons who were overweight and morbid obese the SBP, HOMA-IR, leptin, h-CRP were found significantly high in the group of morbid obese. In the grouping process which was carried out according to the diagnosis of MetS the SBP, weight, waist circumference, WHR, fasting-postprandial glucose, uric acid, triglyceride, HOMA-IR MetS group.

Conclusion: The existence of correlations that is determined in all cases by the ferritine has a unique nature as to support the hypothesis which is brought forward in the course of some studies whether or not the ferritine might be considered a parameter of MetS. However, the statistical data obtained from the comparison of groups that are formed according to the values of BMI, MetS and IR, have not enabled the continuance of such hypothesis. The assessment to be conducted in the future groups wherein the number of cases would be rather high, will enable us to crystallize our data on this subject.

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