Endocrine Abstracts (2009) 20 P498

The effect of [alpha]-lipoic acid on myostatin and myosin heavy chain isoform profile of skeletal muscle of OLETF rats

Soon Jib Yoo1, Oak Kee Hong1, Do Man Kim2, Hyuk Sang Kwon1, Ho Young Son1, Sung Koo Kang1 & Dong-Sun Kim3

1The Catholic University of Korea, Seoul, Republic of Korea; 2Kandong Sacred Hospital, Seoul, Republic of Korea; 3Hangyang Univeristy, Seoul, Republic of Korea.

Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.

Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.

Results: The treatment of ALA with or without insulin reduce body weight significantly and save relatively larger amount of skeletal muscle mass from gastrocnemius compared with insulin-alone treated group and control group of OLETF rats. Myostatin gene expression in skeletal muscle was decreased in ALA-alone and insulin alone treated group compared with control group of OLETF and LETO rats. The isoform profile of MHC was significantly increased in MHC I, MHC IIa and MHC IId/x in ALA-alone treated group compared with the control group of OLETF rats.

Conclusion: The short-term treatment with ALA showed preventing weight gain, preserving skeletal muscle mass, decrement of myostatin gene expression and increment of both MHC I and IIa gene expression.

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