Endocrine Abstracts (2009) 20 P505

Anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes

Leila Ben Salem Hachmi1, Chiraz Bouzid1, Leila Ben Farhat2, Azza Doraï1, Ridha Waghlani1, Lotfi Hendaoui2 & Claude Ben Slama1

1National Institute of Nutrition, Tunis, Tunisia; 2Mongi Slim Hospital, Marsa, Tunis, Tunisia.

Aim: The aim of the study was to assess the association between anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes.

Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. Clinical and biochemical variables were examined with univariate and multivariate analysis. Receiver operating characteristic (ROC) curves were used to identify the sensitivity and specificity.

Results: The global prevalence of hepatic steatosis was 30% (24/80). Body mass index and waist circumference were significantly higher in diabetes with steatosis (respectively 33.3±6 vs 29.5±7.4 kg/m2 P=0.038 – 109±12.4 vs 109±12.4 cm P=0.0004). BMI≥30 kg/m2 and WC≥94 cm were significantly associated with an increased risk of hepatic steatosis (respectively: OR=4 CI 95% 1.4–12.5 P=0.005 – OR=5.6 CI 95% 1.2–26.6 P=0.017).

Conclusion: Obesity and visceral fat distribution are a high risk factor of hepatic steatosis in type 2 diabetic patient. Life style intervention must be intensifying in obese diabetic patient to improve insulin sensitivity.

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