PRL hypersecretion is the most common endocrine abnormality due to hypothalamicpituitary disorders. PRL is the hormone most commonly secreted in excess by pituitary adenomas. Patients usually present with oligo-amenorrhea, galactorrhea, loss of libido, impotence and infertility. If the tumor extends outside of the sella, visual deficit or other mass effects may be seen.
A retrospective study was performed during the period 19992008. The diagnosis of prolactinoma was based on objective examination, hormonal levels and MRI.
During these time 51 cases were diagnosed as prolactinoma; 68.62% were females and 31.38% were males. Female/male ratio was 2.18:1. The mean age of diagnosis was 36.31±13.58 (range 1877 years) years old. Oligomenorrhea or amenorrhea were the major symptoms in 21 patients (41.1%) and followed by headache in 11 patients (21.5%), galactorrhea in 9 patients (17.6%), decreased libido in 6 patients (11.7%) and visual deficit in 1 patient. Of 3 patients (5.88%) was asymptomatic. Hypopituitarism was found 18 patients (35.3%). The diagnosis of prolactinoma was confirmed by MRI. The 56.8% of cases was macroadenoma and 41.2% of cases was microadenoma.
The mean value of PRL at the moment of diagnosis was 720.64±1086.2 (range 61.53919) ng/ml. PRL normal range is 3.424.1 ng/ml.
25 - 29 Apr 2009
European Society of Endocrinology