Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology

Poster Presentations

Neuroendocrinology, Pituitary and Behaviour

ea0020p544 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The effects of selective serotononin reuptake inhibitors on the thyroid axis in perimenopausal depression

Karaoulanis Sokratis , Rizoulis Andreas , Lalios Georgios , Damani Eleni , Rizouli Katerina , Liakos Nikos , Papadimitriou Alexandros , Angelopoulos Nikiforos

Introduction: There is a great interest in the association of thyroid hormones and mood. Although it appears to be important interactions between the central regulation of mood and the thyroid axis, the effects of antidepressants and especially of selective serotonin reuptake inhibitors (SSRIs) remain ambiguous. We investigated the thyroid function in perimenopausal women suffering from depression.Material and methods: We examined 102 perimenopausal wome...

ea0020p545 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Pre-treatment IGF-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease

Biermasz Nienke R , Wassenaar Moniek J E , van der Klaauw Agatha A , Pereira Alberto M , Smit Johannes W A , Roelfsema Ferdinand , Wolterbeek Ron , Kroon Herman M , Kloppenburg Margreet , Romijn Johannes A

Objective: To identify factors influencing the development of osteoarthritis during long-term control of acromegaly, focusing on disease specific parameters, growth hormone (GH) and insulin-like growth factor I (IGF-I) concentrations and duration of disease, adjusted for the well-known determinants of primary osteoarthritis.Design: Follow-up study.Methods: We studied 67 patients, with adequate biochemical control of acromegaly for ...

ea0020p546 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The prevalence of diabetes mellitus in 9776 adult patients with childhood- and adult-onset growth hormone (GH) deficiency before GH replacement: a KIMS analysis

Abs Roger , Luger Anton , Wilton Patrick , Thunander Maria , Verhelst Johan , Goth Miklos , Koltowska-Haggstrom Maria , Mattsson Anders

Background: Untreated GH-deficiency (GHD) in adults has been suggested to be associated with an increased prevalence of type 2 diabetes mellitus (DM). Proposed causative factors are the tendency to overweight and the insulin resistance due to central adiposity.Patients and methods: The KIMS (Pfizer International Metabolic Database) was used to evaluate the prevalence of DM in both childhood-onset (CO; n=1977; 56% males) and in adult-onset (AO; ...

ea0020p547 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Effects of 3 years growth hormone (GH) replacement in adult-onset growth hormone deficiency (GHD) due to controlled Cushing's disease (CD)

Hoybye Charlotte , Jonsson Peter J , Feldt-Rasmussen Ulla , Ragnarsson Oskar , Trainer Peter , Biller Beverly , Koltowska-Haggstrom Maria

Objective: Our study evaluates the contribution of untreated GHD to the phenotype in controlled CD, by comparing patients with GHD due to CD (n=322) and those with non-functioning pituitary adenoma (NFPA n=748) before and after 3 years of GH treatment.Methods: The patient cohorts were obtained from KIMS (Pfizer International Metabolic Database) and matched for age and gender. Duration between pituitary disease onset and GH start was 9.7 (CD...

ea0020p548 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The cost-effectiveness of growth hormone (GH) treatment (Genotropin®) in adult patients with growth hormone deficiency (GHD)

Bolin Kristian , Jonsson Bjorn , Koltowska-Haggstrom Maria , Prutz Christin , Sandin Rickard

Objective: To evaluate cost-effectiveness of GH treatment (Genotropin) in adult patients with GHD by comparing health status and costs in patients who received GH treatment with those who did not.Methods: Direct costs included health care costs related to morbidity (stroke, cardiovascular events) and GH costs. Indirect costs were determined by sick-leave and mortality. A model (Markov-type) was constructed to simulate differences in morbidity and mortali...

ea0020p549 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

High TSH levels in healthy pregnant women are related to a decrease in motor development of their children at 14 months of age

Alvarez Mar , Julvez Jordi , Guxens Monica , Rodriguez Agueda , Martorell Rosa , Espada Mercedes , Sunyer Jordi

Objectives: The fetus is dependent on maternal thyroid hormones during pregnancy and an adequate thyroid function during pregnancy is essential for the normal brain development. The effects of subclinical hypothyroidism during pregnancy are poorly known. The present study assesses the association between thyroid hormones and thyrotropin in healthy pregnant women from the general population, and the neurodevelopment of their children at the age of 14 months.<p class="abstex...

ea0020p550 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly

Bianchi Antonio , Mazziotti Gherardo , Tilaro Laura , Cimino Vincenzo , Porcelli Teresa , Mormando Marilda , Tartaglione Linda , Pontecorvi Alfredo , Giustina Andrea , De Marinis Laura

Clinical trials have demonstrated that pegvisomant therapy is highly efficacious, normalizing serum IGF-I levels in the majority of patients with acromegaly. Multiple factors could influence the dose of pegvisomant required to normalize IGF-I, that ranging from 10 to 40 mg/day. However, the determinants of this variability are unknown and, to date, there is no specific recommendation to adjust the dose to the type of patient. Lack of exon 3 of the Growth Hormone receptor (d3-G...

ea0020p551 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The low-dose ACTH stimulation test in the assessment of outcome of pituitary surgery for Cushing's disease

Alwani Rehmat A , De Herder Wouter W , De Jong Frank H , Van der Lely Aart-Jan , Feelders Richard A

Objective: To evaluate the results of the early postoperative low-dose (1 μg) ACTH (adrenocorticotropin) stimulation test in patients with Cushing’s disease (CD) in order to predict long-term outcome of transsphenoidal surgery.Methods: We reviewed the serum cortisol response to 1 μg synthetic ACTH (1–24) in the second week after pituitary surgery in 40 patients with Cushing’s disease. Median follow-up was 48.5 months (range 6&#15...

ea0020p552 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

Wassenaar Moniek JE , Biermasz Nienke R , van der Klaauw Agatha A , Smit Johannes WA , Pereira Alberto M , Roelfsema Ferdinand , van der Straaten Tahar , Kroon Herman M , Kloppenburg Margreet , Guchelaar HJ , Romijn Johannes A

Objective: To evaluate the impact of the genomic deletion of exon 3 in the growth hormone receptor (d3GHR) on co-morbidities of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.Design: Cross sectional study.Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients and related to clinical outcome, i.e. anthropometric parameters, osteoarthritis, and the metabol...

ea0020p553 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Ghrelin as new provocative test for the diagnosis of GH deficiency in adults

Gasco Valentina , Rovere Silvia , Beccuti Guglielmo , Broglio Fabio , Aimaretti Gianluca , Grottoli Silvia , Casanueva Felipe , Ghigo Ezio

ITT is the test of reference for the diagnosis of adult GH deficiency (GHD), but it is recognized that also GHRH in combination with arginine (ARG) or GH secretagogues (GHS) are equally reliable tests. It has also been suggested that testing with GHS would represent a potent stimulus exploring also the integrity of hypothalamic pathways controlling somatotropic function. We therefore aimed to clarify the diagnostic reliability of testing with ghrelin, the natural GHS. We studi...

ea0020p554 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Screening for neuroendocrine dysfunction in patients after spontaneous subarachnoid hemorrhage

Djurdjevic Sandra Pekic , Jovanovic Vladimir , Stojanovic Marko , Djurovic Branko , Doknic Mirjana , Miljic Dragana , Nikolic-Djurovic Marina , Popovic Vera

Spontaneous subarahnoid hemorrhage (SAH) is a recently identified risk factor for hipopituitarism, especially growth hormone (GH) and corticotroph deficiencies. The aim of this study is to perform the initial screening procedure to identify the patients with increased risk of neuroendocrine dysfunction after SAH in the chronic phase and to identify the possible predictor(s) for neuroendocrine dysfunction. Ninety-one patients (30 males, 61 females), age between 19 and 69 years ...

ea0020p555 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Characterisation of PARS, a novel putative pituitary regulator of hormone secretion

Reiter Marie Helene , Vila Greisa , Knosp Engelbert , Wagner Ludwig , Luger Anton

We present data on open reading frame 62 encoded on human chromosome 6 (C6orf62), a gene whose protein expression and function has not been described to date. The gene product of C6orf62 was designated pituitary associated regulator of hormone secretion (PARS).Initial gene expression screens showed that PARS transcription is differentially regulated in secreting and non-secreting pituitary adenomas, as well as in normal pituitary tissue. Inspired ...

ea0020p556 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Combined treatment for acromegaly with long-acting somatostatin analogues and pegvisomant: long-term safety up to 4.5 years of follow-up in 86 patients

Neggers Sebastian , De Herder Wouter , Janssen Joop , Feelders Richard , Van Der Lely Aart-Jan

Background: We previously reported on the efficacy, safety and Quality of Life of long-acting somatostatin analogs (SSA) and (twice) weekly pegvisomant (PEG-V) in acromegaly and improvement after the addition of PEG-V to long-acting SSA.Objective: To assess the long term safety in a larger group of acromegalic patients over a larger period of time; 29.2 (1.2–57.4) months (mean (range)).Design: Pegvisomant was added to SSA mono...

ea0020p557 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Impact of long-term growth hormone (GH) substitution on lipid metabolism and bone mineralisation (BMD) in pituitary insufficient patients with growth hormone deficiency (GHD)

Roemmler Josefine , Kuenkler Maren , Schopohl Jochen

Introduction: Growth hormone (GH) is a lipolytic hormone with pleitropic metabolic functions. The effects of long-term GH substitution in pituitary insufficient patients with growth hormone deficiency (GHD) on lipid metabolism and bone mineralisation (BMD) have yet to be ascertained.Methods: We measured fasting total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, glucose and insulin concentrations in 52 GHD on ...

ea0020p558 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Effect of intracerebroventricular infusion of bombesin in glucose dependent insulinotropic peptide on conscious dogs

Yavropoulou Maria , Anastasiou Olympia , Kotsa Kalliopi , Yovos John

Several studies have pointed to a neural regulation of glucose dependent insulinotropic peptide (GIP) secretion. Bombesin is a neuropeptide found in the amphibian brain and gastrointestinal system – homologous to the C terminus of gastrin-releasing protein (GRP) in mammalians, which displays a wide range of metabolic actions.Aim: Aim of this study was to investigate the effect of intracerebroventicular infusion of bombesin in a centrally mediated re...

ea0020p559 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Plurihormonal cells are more frequent in early embryofetal stages of the human pituitary

Chirculescu Andy RM , Morris John F , Coculescu Mihail GR

Our initial studies suggested that plurihormonal cells are constantly found in early embryonic stages of human pituitary but are very rare later.Aim: A quantitative evaluation and morphological characterization of these plurihormonal cells.Methods: Pituitaries from therapeutically aborted human fetuses of 8–24 weeks, gestational age were fixed (with ethical permission) by immersion in 4% buffered formaldehyde. One-μm-thic...

ea0020p560 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Ovariectomy causes hippocampal neuronal loss and cognitive dysfunction and restored by Ginkgo biloba extract EGb761 in rats

Koike Koji , Takuma Kazuhiro , Hoshina Yuki , Suzuki Nobutaka , Inoue Masaki , Yamada Kiyofumi

Combination of ovariectomy (OVX) and chronic restraint stress causes cognitive dysfunction and reduces hippocampal CA3 neurons in female rats and that estrogen replacement suppresses the OVX/stress-induced behavioral and morphological changes. Aim of this study is to exsamine the effect of Ginkgo biloba extract (EGb 761) on the cognitive dysfunction and neuromorphological change in OVX/stress-subjected rats. Female Fisher 344 rats were randomly divided into three groups...

ea0020p561 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Glucose tolerance and somatostatin analogues treatment in acromegaly: a 12 month open, prospective study

Colao Annamaria , Auriemma Renata S , Savastano Silvia , Galdiero Mariano , Grasso Ludovica FS , Lombardi Gaetano , Pivonello Rosario

Objective: The impact of first-line somatostatin analogues (SSA) on glucose tolerance in acromegaly was investigated during a 10 year period.Patients: One hundred and twelve patients treated with depot SSA.Outcome measures: Primary outcome measures were fasting glucose levels. Data were analyzed according with baseline glucose tolerance and disease control.Results after 12 months SSA treatment: In the 63 pati...

ea0020p562 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Heart rate variability of young men with hypogonadotropic hypogonadism

Deniz Ferhat , Ermis Necip , Kepez Alper , Kara Batuhan , Omer Azal

Objective: There is little data available regarding the effects of male sex hormones on cardiac autonomic function. The aim of this study is to evaluate the association between male sex steroids and cardiac autonomic function by comparing heart rate variability (HRV) parameters of young male hypogonadotropic hypogonadism patients to those of healthy controls.Design: The study consisted of 22 male hypogonadotropic hypogonadism patients (mean age 20.8&#177...

ea0020p563 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The impact of infertility on the relationship of people with a Pituitary condition

Morris Marianne , Harrison Pascale

Background: Evidence from a Needs Analysis (2006) and Patient Satisfaction Survey (2008) for people with pituitary conditions, suggested infertility was a key yet unexpected problem for the majority of respondents. Being infertile without the co-morbidity of having a pituitary condition confers a huge emotional burden on the couple concerned. The aim of this study was to explore in detail the effects infertility imposed on people with a pituitary condition.<p class="abstex...

ea0020p564 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Carotid intima media thickness and other cardiovascular risk factors in acromegalic patients

Sancak Seda , Yalin Ayse Serap , Ozben Beste , Deyneli Oguzhan , Gunes Mutlu , Yavuz Dilek Gogas , Akalin Nefise Sema

Cardiovascular diasease (CV) is the leading cause of mortality in acromegalic patients. Although acromegalic cardiomyopathy has been extensively investigated, there is a lack of data about atherosclerosis in acromegaly.We aimed to the evaluate the extent of carotid atherosclerosis with various CV biomarkers in acromegaly. Sixty-one acromegalic patients and 21 age and sex matched healthy controls were included. We measured carotid intima media thickness (...

ea0020p565 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Expression and regulation of HIF-1α and RSUME in murine and human pituitary tumor cells

Shan Bing , Theodoropoulou Marily , Buchfelder Michael , Rachinger Walter , Losa Marco , Stalla Gunter , Arzt Eduardo , Renner Ulrich

Hypoxia inducible factor-1alpha (HIF-1α) is a transcription factor regulating expression of many genes related to oxygen homeostasis in response to hypoxic stress. RSUME is a sumoylation enhancer, which was recently cloned from a pituitary cell line with an increased tumorigenic and angiogenic potential. It has been shown that RSMUE is induced by hypoxia and enhances the sumoylation of HIF-1α. Although many studies demonstrated that the level of HIF-1α is remark...

ea0020p566 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

MicroRNA expression in human sporadic pituitary adenomas

Butz Henriett , Liko Istvan , Boyle Belema , Czirjak Sandor , Igaz Peter , Patocs Attila , Racz Karoly

Introduction: MicroRNAs (miRs) are 16–29 nucleotide long, non-coding RNA molecules that post-transcriptionally regulate gene expression via RNA interference. It has been shown that they participate in control of cell proliferation, cell differentiation, signal transduction, cell death and carcinogenesis.Aim: To examine the role of the miRs in sporadic pituitary tumourigenesis.Methods: Twenty-five sporadic pituitary adenoma spe...

ea0020p567 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Progesterone up-regulates transthyretin levels in primary cultures of choroid plexus epithelial cells

Quintela Telma , Alves Henrique , Goncalves Isabel , Baltazar Graca , Santos Cecilia

Transthyretin (TTR) is a protein mainly synthesized by the liver and choroid plexus (CP) of the brain. Besides its role as a carrier for thyroid hormones, TTR also sequesters the amyloid beta (Aβ) peptide impairing its deposition in nervous tissues, and its concentrations in the cerebrospinal fluid (CSF) appear to be inversely correlated with Alzheimer’s disease (AD) onset and progression. Abundant evidence suggests that the depletion of progesterone (PROG) at menopa...

ea0020p568 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Long-term follow-up of female patients with prolactinoma: is there a place for surgery in the therapy of prolactinoma?

Frey Janine , Krull Ina , Sahli Rahel , Stettler Christoph , Fischli Stefan , Diem Peter , Christ Emanuel

Background: Medical therapy with dopamine agonists (DA) is the primary treatment in most patients with prolactinomas. ‘Classical’ surgical indications are mainly intolerance of DA therapy or non-responders. Focusing on a possible shift of recent indications towards a surgical approach, we retrospectively analyzed the long-term results of surgical treatment and compared them to the medically treated female patients with prolactinomas.Patients an...

ea0020p569 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Clinical presentation, long-term follow-up and bone morbidity of male patients with prolactinoma

Frey Janine , Krull Ina , Sahli Rahel , Stettler Christoph , Fischli Stefan , Diem Peter , Christ Emanuel

Background: In contrast to females with prolactinoma, male patients usually present with a history of long-standing hypogonadism and a macroadenoma on MRI-scan. Data is scarce about the effect of hypogonadism on bone health in these patients. We, therefore, investigated retrospectively the cohort of male patients with prolactinoma at our institution.Patients and methods: Between 1983 and 2007, the chards of 44 male patients with prolactinoma were reviewe...

ea0020p570 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Effects of somatostatin analogs on glucose homeostasis: a meta-analysis of acromegaly studies

Mazziotti Gherardo , Floriani Irene , Bonadonna Stefania , Torri Valter , Chanson Philippe , Giustina Andrea

Objective: Somatostatin analogues (SSA) are widely used for the treatment of patients with neuroendocrine tumors. These drugs are able to influence glucose metabolism by an inhibitory effect of insulin secretion, but the clinical impact of this effect is uncertain. Most of the data on this topic have been obtained from studies including patients in acromegaly, one the major indication for SSA, which are limited in terms of numerosity and study duration. Therefore, we have carr...

ea0020p571 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Macroprolactinemia in patients with pituitary adenomas

Dzeranova LK , Giniyatullina EN , Barmina II , Dobracheva AD , Goncharov NP

Elevated macroprolactin level is one of the reason of misdiagnosis and mismanagement of hyperprolactinamia. About 10% of population have incidentalomas and it also can combine with increasing of prolactin (Prl).Three hundred and thirty patients with hyperprolactinemia (Prl>600 mU/l) were studied: 192 women and 138 men in age of 30 (25; 39) and 35 (29;46) years respectively. Clinical, biochemical and MRI methods were used. Prl, LH, FSH and Testosteron...

ea0020p572 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Primary medical treatment of large and giant prolactinomas

Astafieva Ludmila , Kadashev Boris

Objective: Prospective study of medical treatment effect in newly diagnosed patients with large and giant prolactinomas.Patients and methods: The study group included 45 patients with large prolactinomas (tumors more 3,6 cm) and 23 patients with giant prolactinomas (tumors more than 6 cm); from them 8 mainly cystic tumors. The treatment period was 3–24 month (mean 6). Serum prolactin level before treatment ranged between 12 990 and 1 038 000 mU/l (m...

ea0020p573 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Transport activities and plasma membrane localization of MCT8 mutant proteins identified in patients with severe psychomotor retardation depend on cell type. Implications for the interpretation of clinical phenotypes

Kinne Anita , Roth Stephan , Schweizer Ulrich , Kohrle Joseph

Objective: Mutations in the gene encoding the thyroid hormone transport protein, monocarboxylate transporter 8 (MCT8), underlie severe mental retardation. In vitro expression of mutant transporters was performed to understand phenotypical differences.Methods: We established cell lines stably expressing 16 MCT8 variants in JEG1 and MDCK cells. Several of these mutants have never been analysed before. The cell lines were characterized according to M...

ea0020p574 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Is it possible to avoid hypopituitarism after the irradiation of pituitary adenomas by the Leksell gamma-knife?

Marek Josef , Jezkova Jana , Hana Vaclav , Krsek Michal , Liscak Roman , Vladyka Vilibald

Radiation therapy is used in the treatment of pituitary adenomas, especially in failures of neurosurgery and pharmacotherapy to reduce the size of adenomas and normalize their hypersecretion. Conventional fractionated radiotherapy has achieved good results, but only after a long latency, with considerable postradiation morbidity and with very frequent appearance of hypopituitarism. The focal stereotactic targeting allowed by Leksell gamma-knife (LGK) was supposed to decrease t...

ea0020p575 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Effect of prolonged treatment with potassium canrenoate, a MR antagonist, on basal and stimulated hypothalamus–pituitary–adrenal (HPA) axis in humans

Berardelli Rita , Marinazzo Elisa , Prats Elisa , Picu Andreea , Giordano Roberta , Ghigo Ezio , Arvat Emanuela

HPA is negatively regulated by glucocorticoid feed-back at hypothalamic, pituitary and hippocampal level by glucocorticoid (GR) and mineralcorticoid (MR) receptors. MR antagonists impair HPA rhythm after acute administration. The aim of this study was to verify HPA activity and glico-insulinemic profile both basally and after acute administration of potassium canrenoate (CAN), before and after chronic treatment. We evaluated ACTH, cortisol (F) and dehydroepiandosterone (DHEA) ...

ea0020p576 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Initial and long-term outcome of surgery in acromegaly: a ten-year, single centre study in 115 patients

Albarel Frederique , Castinetti Frederic , Morange Isabelle , Dubois Noemie , Dufour Henry , Conte-Devolx Bernard , Brue Thierry

Objective: To analyze characteristics of patients who had surgery for a GH-secreting adenoma in the past decade in our centre, to evaluate their initial outcome and long-term recurrence rate using stringent criteria and identify potential predictive factors of surgical remission.Methods: This retrospective study included 115 consecutive patients with acromegaly operated at the neurosurgical department of the Timone Hospital Marseille between 1997 and 200...

ea0020p577 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Two repeated restraint stress paradigms differing in duration and frequency result in similar levels of HPA habituation, but differences in neuropeptide expression and testosterone levels

Gray Megan , Bingham Brenda , Viau Victor

The dampening of hypothalamic–pituitary–adrenal (HPA) axis responses to a repeated stress is termed HPA habituation. We investigated here the effects of two commonly used repeated restraint stress paradigms, in which rats are exposed either to 10 episodes of 0.5 h restraint or 5 episodes of 3 h restraint. We compared ACTH, corticosterone, and testosterone responses, as well as corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA levels within bra...

ea0020p578 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Association of Interleukin-6 with hot flashes in perimenopausal women

Karaoulanis Sokratis , Rizouli Katerina , Rizoulis Andreas , Lalios Georgios , Theodoridou Katerina , Angelopoulos Nikiforos V

Introduction: Hot flashes and night sweating are the most common medical complaints in women during the menopausal transition and they are strongly associated with the presence of perimenopausal depression. The pathophysiology of hot flashes has not been elucidated. Peripheral vasodilation and increase in skin temperature observed in women with hot flashes might be induced by changes in brain neurotransmitters and instability in the hypothalamic thermoregulatory center due to ...

ea0020p579 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Empty sella and primary autoimmune hypothyroidism

Garcia-Centeno Rogelio , Suarez-Llanos Jose-Pablo , Fernandez-Fernandez Elisa , Andia-Melero Victor , Sambo Marcel , Sanchez Petra , Jara-Albarran Antonino

Objective: To assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis.Patients and methods: We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated and followed up by our Endocrinology Department. Subjects with a known aetiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A tot...

ea0020p580 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Human corticotropin releasing hormone (hCRH) test performance in the differential diagnosis between Cushing's disease and pseudo-Cushing state is enhanced by combined ACTH and cortisol analysis

Tirabassi Giacomo , Arnaldi Giorgio , Papa Roberta , Furlani Giorgio , Trementino Laura , Cardinaletti Marina , Faloia Emanuela , Boscaro Marco

Objective: The corticotropin releasing hormone (CRH) test does not reliably distinguish between Cushing’s disease (CD) and normality or pseudo-Cushing state (PC). In this study we assessed whether the application of novel criteria could enhance its diagnostic performance.Design: Retrospective study.Patients: Fifty-one subjects with CD, 26 with PC and 31 control subjects (CT).Measurements: All subjects un...

ea0020p581 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Hemostatic and fibrinolytic changes in patients with Cushing's disease

Chodakova Juliya , Arapova Svetlana , Chirkova Lidiya , Rozhinskaya Ludmila , Suhanova Galina

Introduction: Chronic endogenous hypercortisolism is characterized by abdominal obesity, systemic arterial hypertension, glucose and lipid abnormalities, insulin resistance, osteoporosis. This syndrome also has features of hypercoagulation. The mortality rate in patients with active Cushing’s disease (CD) is four times higher than in age- and sex- matched population. The main cause is cardiovascular disease with thrombotic complications.Objective: T...

ea0020p582 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Immunoassay determination of macroprolactin in hyperprolactinemic patients: an interassay comparative study

Martinho Mariana , Martinho Teresa , Cunha Nuno , Curado Fatima , Gomes Leonor , Valido Frederico , Naidenov Plamen , Rodrigues Fernando

Prolactin is mainly found in the monomeric form although it can also occur in the big-PRL and bigbigPRL (bbPRL) form: a complex of prolactin and immunoglobulin G. The latter has reduced bioactivity despite maintaining its imunorreactivity. This can cause false positive results representing the main cause of interassay variability in prolactin measurement. It should therefore be considered in every study concerning hyperprolactinemia. We aimed to evaluate the prevalence of bbPR...

ea0020p583 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Adiponectin and visfatin: a link with bone mineral density in acromegaly

Resmini Eugenia , Sucunza Nuria , Barahona M Jose , Santos Alicia , Fernandez-Real J Maria , Ricart Wilfredo , Moreno J Maria , Farrerons Jose , Espinosa Jose Rodriguez , Marin AM , Webb Susan M

Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties, and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly data on adiponectin are contradictory and there are no data on visfatin.Objectives: To evaluate adiponectin and visfatin in acromegaly, compared to control subjects and to analyze their relationship with body composition and bone mineral mar...

ea0020p584 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Feedback inhibition of prednisolone on vasopressin (AVP) secretion but preserved renal water reabsorption after thirsting point to an AVP independent antidiuretic action

Ufer Friederike , Mai Knut , Diederich Sven , Pedersen Erling , Pfeiffer Andreas , Bahr Volker

Adrenal insufficiency can result in severe hyponatremia due to inappropriate high plasma vasopressin (pAVP). To elucidate the glucocorticoid AVP feedback we monitored thirsting of 12 male volunteers without and after on or five days of prednisolone (30 mg/d). Although prednisolone suppressed pAVP below 0.2 pg/ml the rise in plasma osmolality during thirsting was not influenced by prednisolone. Independent of exogenous glucocorticoid thirsting resulted in higher urine osmolalit...

ea0020p585 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Genetic alterations of phosphodiesterase 11A (PDE11A) in acromegalic patients

Peverelli Erika , Ermetici Federica , Filopanti Marcello , Lania Andrea , Ferrero Stefano , Beck-Peccoz Paolo , Spada Anna

Background: Aberrant cAMP signalling is involved in the pathogenesis of somatotropinomas. Recently, variants of phosphodiesterase type 11A (PDE11A) gene have been described in patients with adrenocortical tumors. Aim of the study was to investigate the presence of these variants in patients with somatotropinomas.Subjects and methods: Germ-line DNA of 78 acromegalic patients was screened for known genetic variants of PDE11A by direct sequencing or restric...

ea0020p586 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Neuroendocrine effects of stress in hostile heavy social drinkers: exploring the involvement of serotonin using dietary tryptophan manipulation

Nesic Jelena , Duka Theodora

Previous studies suggest that individuals characterized by high trait hostility may be more sensitive to stress and that this may contribute to their greater vulnerability to alcohol abuse. To characterize the stress reactivity of hostile individuals and to evaluate the possibility that serotonergic dysfunction may underlie their susceptibility to stress, we examined the effects of acute dietary tryptophan enhancement and stress on mood and physiological reactivity in low (LoH...

ea0020p587 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

GH response to oral glucose tolerance test: a comparison between patients with pituitary disease and healthy subjects

Verrua Elisa , Ronchi Cristina Lucia , Ferrari Daniela Ilaria , Olgiati Luca , Ferrante Emanuele , Filopanti Marcello , Lania Andrea Gerardo , Beck-Peccoz Paolo , Spada Anna

Background: GH response to oral glucose tolerance test (OGTT) is currently used for the definition of disease remission in acromegaly. This test has been poorly investigated in other pituitary diseases.Aim: To evaluate the impact of a pituitary disease other than acromegaly on GH response to OGTT.Patients and methods: Eighteen patients (13 F & 5 M, age: 50.7±13.1 years) with different pituitary diseases (i.e. non-functioni...

ea0020p588 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Quality of life (QoL) in patients with Cushing's syndrome in a Spanish population: new experience with the CushingQoL questionnaire

Alicia Santos , Eugenia Resmini , Jose Barahona Ma , Camelia Marti , Cheryl Farkas , Olga Roig , Ma Antonia Martinez , Nuria Sucunza , Xavier Badia , Susan M Webb

Quality of life is impaired in patients who have suffered Cushing’s syndrome (CS).Aim: Evaluate QoL with the new questionnaire CushingQoL in Spanish patients in a clinical practice setting and compare it with a generic QoL questionnaire, EuroQoL-5 Dimensions (5D) and its Visual Analogue Scale (VAS).Patients and methods: Forty-three patients with CS (38 pituitary-dependent, 28 cured) were approached during their regular endocri...

ea0020p589 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Five year experience with GH replacement therapy on tumor occurrence or recurrence: one center study

Di Somma Carolina , Rota Francesca , Savanelli Maria Cristina , Lombardi Gaetano , Colao Annamaria

GH replacement is widely used in adults with hypopituitarism, but its effect on tumor occurrence and pituitary tumor recurrence is unknown. Furthermore, in literature there are scant with short follow-up time. The available data do not seem to suggest that rhGH replacement increased the incidence of regrowth of pituitary tumor and of cancer in adults with GHD, provided that IGF-1 concentrations remain within the normal range for age.The aim of our study ...

ea0020p590 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Androgen deficiency is additional risk factor for bone health in growth hormone deficient men

Stojanovic Marko , Pekic Sandra , Miljic Dragana , Nikolic-Djurovic Marina , Doknic Mirjana , Popovic Vera

Growth hormone deficiency (GHD) impairs bone mass and strength. Androgen deficient men exhibit impaired bone mass, but the extent to which testosterone replacement can prevent this remains disputable. The aim of this study was to assess whether androgen deficiency presents an additional risk factor for bone health in male patients with GHD and whether this is correctable by testosterone substitution.A group of 81 male patients with GHD, not receiving GH ...

ea0020p591 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The correlations of ghrelin concentrations and lipid profile in patients with acromegaly

Jaskula Magdalena , Wasko Ryszard , Komarowska Hanna , Dziubandowska Aleksandra , Sowinski Jerzy

The role of ghrelin in the pathogenesis of acromegaly is doubtful. Ghrelin also regulates glucose and adipose tissue metabolism. It has not been demonstrated whether it contributes to the development of metabolic complications of acromegaly.Aim: The aim of the study was to assess: (1) whether serum concentrations of total and acyl ghrelin in patients with acromegaly differ in relation to coexisting metabolic complications (hypercholesterolemia, hyperinsu...

ea0020p592 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Glucose metabolism alterations in acromegaly

Ambrosio Maria Rosaria , Malaspina Alessandra , De Paola Grazia , Bondanelli Marta , Zatelli Maria Chiara , degli Uberti Ettore

Glucose metabolism alterations are frequently observed in acromegalic patients. Somatostatin analogues (SSTA) are the most widely used drugs to treat acromegaly, since they inhibit GH and IGF-1 levels, reduce pituitary mass, but can affect glucose metabolism. Aim of our study was to evaluate glucose metabolism alterations in acromegalic patients cured after surgery and in patients with active disease during treatment with SSTA. We studied 10 patients (group A, 5F, 55.66±1...

ea0020p593 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

ACTH-secreting bronchial carcinoid: a role of somatostatin analogues in diagnosis and treatment

Pavlova Maria , Koloda Dmitry , Pronin Vyacheslav , Zykova Polina , Harnas Sergey , Ippolitov Leonid , Egorov Alexey , Polunin Georgy , Yankin Pavel

Objective: To report a case of Cushing’s syndrome due to ectopic ACTH secretion and to evaluate role of somatostatin analogues for the localization and postoperative treatment of adrenocorticotropin-secreting bronchial carcinoid tumor.Methods: We describe the clinical presentation of our case and discuss its management.Results: A 57-year-old woman presented with symptoms and physical findings strongly suggestive of Cushing syn...

ea0020p594 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Dose interval comparison of Lanreotide Autogel 120 mg in acromegalic patients previously treated with Octreotide LAR

Schopohl Jochen , Badenhoop Klaus , Beuschlein Felix , Droste Michael , Plockinger Ursula , Petersenn Stephan , Strasburger Christian

Acromegalic patients under treatment with Octreotide LAR (Oct), 10, 20 or 30 mg were switched to Lanreotide Autogel 120 mg (Lan) at different dose intervals: 56, 42 and 28 days respectively. Just before the fourth Lan injection, IGF-I values were measured and the dose interval for the final three injections adjusted accordingly: if IGF-I values were between 1 and 2 standard deviations (S.D.) above the age and sex related mean value, no change in dose-interval wa...

ea0020p595 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Growth hormone replacement therapy in adult onset growth hormone deficiency induces favorable long-term effects on quality of life, bone, body composition and lipids: a 55 month prospective study

Jorgensen Anders Palmstrom , Fougner Krisitan J , Schreiner Thomas , Bollerslev Jens

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

ea0020p596 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

GH deficiency in HIV-infected patients with lipodystrophy: preliminary data on the effects of r-hGH treatment on body composition

Zirilli Lucia , Orlando Gabriella , Brigante Giulia , Squillace Nicola , Diazzi Chiara , Carani Cesare , Guaraldi Giovanni , Rochira Vincenzo

Introduction: HIV-infected patients often display a moderate to severe GH deficiency (GHD). To investigate the effects of r-hGH on hormonal parameters and body composition in patients with HIV-related lipodystrophy (HIV-r-L) and concomitant GHD, we studied 60 patients with HIV-r-L, 28 male and 32 females aged 18–65 years. According to their response to GHRH+Arginine (GH peak assumed to be normal when >7.5 ng/ml) patients were assigned to the following 3 groups: Group ...

ea0020p597 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Can the pineal gland modulate the effects of kisspeptin on the puberty onset in female rats?

Kelestimur Haluk , Yilmaz Bayram , Ayar Ahmet , Kilic Ertugrul , Ozcan Mete , Kilic Ulkan , Alcin Ergul

Chronic central administration of KiSS-1 peptide to immature female rats induces pubertal maturation, characterized by advanced vaginal opening, increased uterine and ovarian weights, elevated levels of luteinizing hormone (LH) and estrogen. There is evidence that the pineal gland may be also involved in puberty onset because melatonin secretion declines near puberty. We have investigated whether there is an interaction between kisspeptin and melatonin in timing of puberty ons...

ea0020p598 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Central diabetes insipidus after transsphenoidal treatment for tumors of the sellar region: prognostic factors for transient course of the disease

Pigarova Ekaterina , Rozhinskaya Liudmila , Grigoriev Andrey , Dzeranova Larisa

Central diabetes insipidus (CDI) is a common complication after transsphenoidal treatment for tumors of the sellar region and may exhibit different patterns: transient, permanent or triphasic.The aim of our study was to determine the incidence and course of the CDI and to characterize the factors associated with resolution of this disease.The incidence of CDI was based on records of 318 patients who underwent transsphenoidal surger...

ea0020p599 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Food deprivation affects arcuate neurons in the hypothalamus of young rats

Kubasik-Juraniec Jolanta , Knap Narcyz

The arcuate nucleus of the hypothalamus (ARH) is localized within lateral walls of the third ventricle above the median eminence. From the functional point of view ARH takes part in the regulation of food intake, energy expenditure and body weight. The aim of this study was to investigate the influence of food deprivation on ultrastructural alterations of the rough endoplasmic reticulum (RER)/Golgi network in the arcuate neurons of young rats. There have been no reports descri...

ea0020p600 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Plasma levels of neuropeptide Y and peptide YY in patients affected by Anorexia nervosa and severe obesity

Masoni Maria Chiara , D'Alessandro Claudia , Scarpellini Claudio , Ghiadoni Lorenzo , Taddei Stefano

Anorexia nervosa (AN) and obesity are prevalent in modern societies.This study evaluate circulating levels of Neuropeptide Y (NPY) and of Peptide Tyrosine-Tyrosine (PYY) in 60 women: 20 affected by AN (Body Mass Index=BMI 15.74±2.09 kg/m2, age 30.19±10.52 years), 10 restricter (BMI 14.89±1.64 kg/m2) and 10 binge-purge subtype (BMI 18.27±0.81 kg/m2); 20 affected by severe Obesity (BMI>...

ea0020p601 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

From the horse’s mouth: recommendations to improve care for pituitary patients. Results from a survey on pituitary patients’ satisfaction with information and support from healthcare professionals

Jackson Sue , Morris Marianne , Murray Jane , Woods Tony

Introduction: Pituitary conditions are rare and diagnosis may be slow because symptoms are ambiguous. The treatment may be a combination of surgery, radiotherapy and medication so patients see many healthcare professionals (HCPs). This survey sought to assess patient satisfaction with the information and support they receive from GPs, endocrinologists, neurosurgeons, radiotherapists, specialist nurses, and other agencies (e.g. the pituitary foundation).M...

ea0020p602 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Pituitary insufficiency with a HESX1 mutation: a new case

Lecomte Pierre , Saveanu Alexandranu , Barlier-Setti Anne , Brue Thierry , Lecomte Claire , Barrande Gaelle , Chabrolle Christine , Pierre Peggy

A 14 year-old Turkish boy sought advice for growth retardation. Pituitary insufficiency with GH, TSH, ACTH and gonadotrophin defect was diagnosed and treated. He was born from a consanguineous family and was married at 24. Three years later he consulted wishing to father a child. He was treated with levothyroxine 150 μg, hGH 0,5 mg/day, hydrocortisone 20 mg/day and was switched from testosterone enantate to hCG+FSH. Azoospermia was initially found and oligospermia after t...

ea0020p603 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Prevalence of colonic polyps in acromegalic patients and relationship between glycemic status

Tutuncu Yasemin , Aydin Yusuf , Berker Dilek , Isik Serhat , Akcil Gulhan , Yuksel Osman , Delibasi Tuncay , Guler Serdar

Objective: Acromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence of colonic polyps in acromegalic subjects, and also whether there is a relationship between insulin-like growth factor 1 (IGF-1), growth hormon (GH), fasting insulin plasma levels and the presence of polyps.Material and methods: Fifty-four consecutive acromegalic patients and 45 IBS patients were enrolled to study betwe...

ea0020p604 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Results of acromegaly patients treated with surgery and/or somatostatin analog and/or radiotherapy in a University Hospital in Turkey

Demir Ozgur , Tonyukuk Gedik Vedia , Emral Rifat , Faik Erdogan Murat , Gullu Sevim , Corapcioglu Demet , Uysal Ali Riza , Baskal Nilgun , Kamel Nuri

Background: Transsphenoidal adenomectomy is the first choice of therapy, but about 50% of patients are not cured and require medical treatment and/or radiotherapy. We retrospectively analyzed the data on surgery, sandostatin analog therapy, radiotherapy and the combination of them.Materials-methods: The records of the 96 female and 70 male, totally 166 acromegalic patients who had been followed in Ankara University, Endocrinology and Metabolic Diseases D...

ea0020p605 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Hypothalamic–pituitary–adrenal axis in chronic fatigue syndrome

Marina Djordje , Jelic Svetlana , Kostic Nada , Caparevic Zorica , Trbojevic Bozo , Beleslin Biljana , Ilic Sanja , Zarkovic Milos

Background/objectives: The aim of the study was to assess hypothalamic–pituitary–adrenal (HPA) axis in patients with chronic fatigue syndrome (CFS).Design and methods: Twenty-three consecutive patients who fulfilled centers for disease control (CDC) criteria for CFS and twenty healthy controls were included in the study. Low dose ACTH test (1mcg of synthetic adrenocorticotropic hormone Synacthen) and insulin tolerance test (ITT) were done and b...

ea0020p606 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Normalization of ACTH and cortisol responses to ghrelin in patients cured from Cushing’s disease

Miljic Dragana , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Djurovic Marina , Popovic Vera

Previous studies have shown exaggerated ACTH and cortisol responses to ghrelin. Seven patients who were cured by transsphenoidal operation from CD were included in the study and tested with ghrelin (1 mcg/kg i.v.) before and six months after the operation. Their results were compared with eight healthy control subjects. Results are presented as mean±S.D. Mann–Whitney and Wilcoxon signed rank test were used for statistical analysis.<p class="abstext...

ea0020p607 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The role of androgen receptors in the medial amygdala on biosynthesis and stress-induced cellular activation of the paraventricular nucleus of the hypothalamus

Bingham Brenda , Gray Megan , Viau Victor

Although it is becoming increasingly clear that testosterone exerts an inhibitory influence on stress-induced adrenocorticotropin (ACTH) and corticosterone release, where and how this occurs in the brain remains poorly understood. We previously determined that androgen receptors are not distributed within anterior pituitary communicating neurons of the paraventricular nucleus (PVN) of the hypothalamus (Bingham et al. J Comp Neurol 2006). However, they are contained with...

ea0020p608 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

GH resistance in a group of chronic fatigue syndrome patients

Coucke Francis , Dockx Yanina

Objective: The rule of GH and IGF1 in the pathogenic of CFS is unclear. One study (related articles number 2) found no difference in IFG1 levels between controls and patients. However in fibromyalgia there are reports of subgroups of patients with a low IGF1 and normal to high GH. This phenomenon is also known with anorexia nervosa patients due to the malnutrition.Method: We selected a group of ambulatory CFS patients fulfilling the Fukuda criteria with ...

ea0020p609 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Presenting pattern and etiologies of hyperprolactinemia in north west of Iran

Aliasgarzadeh Akbar

Background: Hyperprolactinemia is the most common endocrine disorder of the hypothalamic–pituitary axis. We have not any documented data about frequency of various etiologies of hyperprolactinemia in our region. For determination of the pattern of presentation and distribution of causes of hyperprolactinemia the presenting study were designed and conducted.Methods and materials: In a descriptive study, we extract medical records of patient presented...

ea0020p610 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

An exceptional image: multiple sclerosis and hypogonadism

Boente Ruth , Santos Eloisa , Lorenzo Jaime , Antonio Sas Manuel

We present a 27 year-old female patient suffering from multiple sclerosis (MS) since 3 years ago. She currently consults for menstrual disturbances. She has not any neurological secuelae of MS now and she is not on medical treatment. She is with amenorrhea since 10 months ago, but she had been oligomenorrhea just before for 24 months. She doesn’t have any symptoms suspicious for other hormonal impairment. Physical examination is normal.The laborator...

ea0020p611 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Health related quality of life in patients with diabetes mellitus type 2 in comparison to patients with other endocrine diseases

Lasaite Lina , Kazanavicius Gintautas , Stankute Edita , Zasytyte Egidija

Pathophysiological mechanisms of endocrine diseases (and diabetes mellitus type 2 (DM2) among them) impacts person’s health perception and health related behavior as measured by the health related quality of life.Aim: To compare peculiarities of health related quality of life in patients with DM2 and other endocrine diseases under hospital treatment.Methods: Of 60 patients with DM2 and 71 patients with other endocrine diseases...

ea0020p612 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Pregnancy occurs rarely in acromegalic patients: although octreotide therapy in pregnancy seems to be feasible and safe, enough information regarding the use of OCT in pregnancy is not available yet

Kilicli Fatih , Korkmaz Serdal , Dokmetas Sebila , Acibucu Fettah

The patient who was operated because of pituitary macroadenoma causing acromegaly disease had insufficient suppression respond of growth hormone to postoperative oral glucose tolerance test (OGTT). OCT LAR treatment had been started. On the 15.month of the therapy, the patient presented with failure of menstruation since four months, so pregnancy test was performed and pregnancy was diagnosed. The patient had used OCT LAR during the period without knowing that she was pregnant...

ea0020p613 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Observational outcome of Korean acromegalics based on OASIS registry

Kim Sung-Woon

We enrolled 30 acromegalics from 2005.4 to 2007.7 at endocrine outpatient clinic of four academic hospitals. Male to female ratio was equal (15/15). Unsuppressed GH confirmed 28 out of 30 patients with oral glucose tolerance test. Average serum GH level was 28.7 ng/ml, and average IGF-I, 985 ng/ml. Micro- to macroadenoma was 8/22 (26%). Before treatment, 28 out of 30 acromegalics were taken 100 μg of somatostatin suppression test, complete responder (GH was suppressed bel...

ea0020p614 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Plasma thrombin-activatable fibrinolysis inhibitor antigen levels in acromegalic patients

Ozbek Mustafa , Erdogan Mehmet , Ceneli Ozcan , Saltas Hakan , Akbal Erdem , Kizilgun Mustafa , Ureten Kemal

Objective: Acromegaly is associated with increased morbidity and mortality, mostly due to cardiovascular complications. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation/fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). In this study, we aimed to evaluate the levels of TAFI antigen and also its relationship with other markers in a group of patients with acromegaly in compoa...

ea0020p615 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Prolactinoma in east-black sea Turkey: a description of 51 cases

Ucuncu Ozge , Nuhoglu Irfan , Kocak Mustafa , Erem Cihangir , Bahat Kubra Aydin , Ersoz H Onder

PRL hypersecretion is the most common endocrine abnormality due to hypothalamic–pituitary disorders. PRL is the hormone most commonly secreted in excess by pituitary adenomas. Patients usually present with oligo-amenorrhea, galactorrhea, loss of libido, impotence and infertility. If the tumor extends outside of the sella, visual deficit or other mass effects may be seen.A retrospective study was performed during the period 1999–2008. The diagno...

ea0020p616 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Acromegaly in the eastern black sea region of Turkey: a description of 42 cases

Nuhoglu Irfan , Kocak Mustafa , Ucuncu Ozge , Erem Cihangir , Saglam Fatma , Ersoz Onder

Background: Acromegaly is a relatively uncommon disorder (40–68 cases per million population) caused by oversecretion of growth hormone by a tumor of the pituitary gland. Excessive growth hormone (GH) and insulin-like growth factor (IGF) I concentrations cause gradual changes in facial and acral appearances as well as in many internal tissues.Medhods: Medical records of patients with acromegaly seen between 2000 and 2008 at our hospital were reviewe...

ea0020p617 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Long-term treatment of a misdiagnosed TSH-oma patient with antidepressants and antithyroid drugs

Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa , Erem Cihangir , Demirel Adem , Ersoz Onder

Background: Among the disorders causing hyperthyroidism thyrotropin-secreting pituitary adenomas (TSH-omas) are extremely rare and account for <2% of all pituitary adenomas. Failure to recognize a TSH-oma may lead to improper therapy attempts and dramatic consequences. We have reported a patient that wrongly had diagnosed and treated as primary hyperthyroidism for fifteen years.Case: A 50 years old woman who was on the treatment of propilhyourasil (1...