Endocrine Abstracts (2009) 20 P660

Preterm menopause and some of its related factors among over 40 years old women

Mahbobeh Sadeghi, Parvin Mirmiran & Saeid Sadeghian


Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.


Goal: To study Prevalence of Preterm menopause and its relation to obesity; to study relation of DM and the age of the first menorrhoea among women over 40 years old.

Materials and methods: The study was performed on 640 menopause women (with no menorrhoea during the past 12 months) who participated in ‘sugar and lipid’ study of Tehran during 2006 to 2008. With no history of hysterectomy. Preterm menopause was defined as menopause before 48 years old. For studying relation of factors like obesity and DM to incidence of Preterm menopause, just the subjects who had been menopaused maximally in past 36 months were selected (n=212). Preterm menopause was the dependent factor, and BMI and DM were the indepent factors of this study.

Findings: The average age of menopause was 48.3 years (47.9–48.8; CI=0.95), and was significantly lower among subject who had their first menorrhoea before 12 years old (47.5; CI=0.95). Prevalence of Preterm menopause Was 35.8%; among the study subjects. It was significantly higher among the subject with had the first menorrhoea before 12 years old (41.5% comparing to 33.8%; P<0.05). Logistic Regression Analysis test showed that probability of Preterm menopause is higher among DM patients than other subjects (OR=1.4–3.1; P<0.05). There wasn’t any significant relation between obesity and Preterm menopause.

Conclusion: The study showed that there is a direct relation between DM and the age of the first menorrhoea with Preterm menopause; but there wasn’t any significant relation between obesity and Preterm menopause.

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