Endocrine Abstracts

The presentation will provide an introduction to systems biology research and describe the support provided by the UK research councils for research and training in systems biology since 2004/5....

The advent of high throughput techniques and genome sequencing has brought about a new era in the availability of biological data. This has created a need for new approached for data integration and to interpret complex biological data sets. A cell cannot be considered as using a set of independent signalling pathways. Instead, it is now clear that signalling proteins are integrated into a complex network. The human brain cannot handle this complexity. At the same time, we nee...

Endocrine systems are dynamically changing and complex systems. Quantitative measurements of hormones over time became possible with the development of sensitive immunoassays, and it rapidly became clear that hormone release is often pulsatile. The timing of ultradian hormone pulses and circadian variation turns out to be a central characteristic of many systems, and this has required increasing use of mathematical analysis.Regulation of gene expression ...

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The MRC currently operates a ‘highlight notice’ in systems biology for medicine. Highlight notices are requests for applications through the normal response mode route – they represent a priority but do not have a specific budget attached. This notice is of considerable relevance to endocrinology research, as will be discussed at the March meeting. MRC-funded endocrinology researchers are already beginning to use systems approaches with some success, but there i...