Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology


Oral Communications Highlights 2

ea0022h2.1 | Oral Communications Highlights 2 | ECE2010

ESE Young Investigator Award

Quarta Carmelo , Bellocchio Luigi , Mancini Giacomo , Mazza Roberta , Cota Daniela , Braulke Lutzie J , Fekete Csaba , Nisoli Enzo , Pasquali Renato , Lutz Beat , Marsicano Giovanni , Pagotto Uberto

The pharmacological blockade of cannabinoid receptor type 1 (CB1) has been shown to counteract diet induced obesity (DIO). An unsolved question is whether the effects of CB1 blockade on energy balance are due to peripheral or central mechanisms. This is an important clinical issue since the CB1 antagonist drugs have recently been withdrawn from the market due to their psychiatric side effects, and novel drugs selectively acting at peripheral le...

ea0022h2.2 | Oral Communications Highlights 2 | ECE2010

Human recombinant GH replacement therapy in children with pseudohypoparathyroidism type Ia and GH deficiency: first study on the effect on growth

Mantovani Giovanna , Ferrante Emanuele , Linglart Agnes , Cappa Marco , Cisternino Mariangela , Maghnie Mohamad , Beck-Peccoz Paolo , Spada Anna

Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of rare metabolic disorders characterized by hypocalcemia and hyperphosphatemia due to PTH resistance. Heterozygous loss of function mutations in the gene encoding the alpha-subunit of Gs (GNAS) inherited from the mother lead to PHP type Ia. PHP type Ia (PHP-Ia) is a disease in which the physical features (short stature, obesity, round face, brachydactyly and subcutaneous ossifications) that constitute Albri...

ea0022h2.3 | Oral Communications Highlights 2 | ECE2010

ESE Young Investigator Award

Tiemensma Jitske , Kokshoorn Nieke , Biermasz Nienke , Keijser Bart-Jan , Wassenaar Moniek , Middelkoop Huub , Pereira Alberto , Romijn Johannes

Context and objective: Active Cushing’s disease is associated with cognitive impairments. We hypothesized that previous hypercortisolism in patients with Cushing’s disease results in irreversible impairments in cognitive functioning. Therefore, our aim was to assess cognitive functioning after long-term cure of Cushing’s disease.Design: Cognitive assessment consisted of 11 tests, which evaluated global cognitive functioning, memory, and ex...

ea0022h2.4 | Oral Communications Highlights 2 | ECE2010

TAC3 and TACR3 ‘Knockouts’ cause hypothalamic congenital hypogonadotropic hypogonadism in humans

Young Jacques , Bouligand Jerome , Francou Bruno , Raffin-Sanson Marie-Laure , Gaillez Stephanie , Jeanpierre Marc , Brailly-Tabard Sylvie , Guiochon-Mantel Anne

Missense loss-of-function mutations in TAC3 and TACR3, the genes encoding neurokinin B (NKB) and its receptor NK3R, respectively, were recently discovered in kindreds with non syndromic normosmic congenital hypogonadotropic hypogonadism (nCHH), thus identifying a fundamental role of this pathway in the human gonadotrope axis.We investigated the consequences on gonadotrope axis of TAC3 and TACR3 invalidations in adult patients ...

ea0022h2.5 | Oral Communications Highlights 2 | ECE2010

Effects of leptin administration on starvation-induced alterations in hepatic thyroid hormone metabolism in mice

Boelen Anita , Van Beeren Mieke , Vos Xander , Surovtseva Olga , Kwakkel Joan , Fliers Eric

Fasting induces profound metabolic changes in order to decrease energy expenditure and to conserve energy. One of the major adaptations is downregulation of the hypothalamus–pituitary–thyroid (HPT) axis, characterized by decreased serum thyroid hormone levels without an increase in serum TSH or in TRH expression in the hypothalamic paraventricular nucleus (PVN). Leptin has been proposed as a critical signal initiating the neuroendocrine response to fasting as it decr...