Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

Oral Communications

Diabetes and obesity

ea0022oc1.1 | Diabetes and obesity | ECE2010

Role of newly identified immunosuppressive NK cells in autoimmunity

Ehlers Margret , Papewalis Claudia , Jacobs Benedikt , Thiel Annette , Schinner Sven , Willenberg Holger S , Scherbaum Werner A , Schott Matthias

Most recently, a completely new subset of NK cells with immunosuppressive functions has been identified. These cells are able to downregulate conventional NK cells in a PD1-ligand dependent manner and are, therefore, responsible for tumor outgrowth.The aim of our present study was to investigate the role of this new NK subset in autoimmunity. For this purpose, we used two independent mouse models. In the NOD mice, we found a large increase of suppressive...

ea0022oc1.2 | Diabetes and obesity | ECE2010

Glucose insulinotropic peptide (GIP) secretion in type 2 diabetic and obese non-diabetic persons examined by meal test

Skrha Jan , Hilgertova Jirina , Jarolimkova Marcela , Kunesova Marie , Hill Martin

Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in type 2 diabetes mellitus. The aim of this study was to develop a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in type 2 diabetic patients. Seventeen type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. In a mixe...

ea0022oc1.3 | Diabetes and obesity | ECE2010

NME7: a new candidate gene for T2DM

Vcelak Josef , Seda Ondrej , Vankova Marketa , Lukasova Petra , Vrbikova Jana , Tremblay Johanne , Bendlova Bela , Hamet Pavel

The identification of genomic determinants responsible for common multifactorial diseases like type 2 diabetes mellitus (T2DM) is facilitated in large families from relatively genetically-isolated populations and can extend results from GWS based on a case–control cohort to detect rare alleles with strong effects. In order to search for sequence variants conferring risk of T2DM we previously conducted a genome-wide linkage study in 108 French–Canadian families from t...

ea0022oc1.4 | Diabetes and obesity | ECE2010

The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction

Corona Giovanni , Boddi Valentina , Balercia Giancarlo , Giulia Rastrelli , de Vita Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Previous clinical studies on effect of statins treatment on testosterone levels have produced mixed results. The aim of the present study is to evaluate the association between statin therapy and hormonal parameters in a large series of subjects seeking medical care at our Unit for ED.Methods: A consecutive series of 3484 (mean age 51.6±13.1 years) patients with ED was studied.Several hormonal and biochemical par...

ea0022oc1.5 | Diabetes and obesity | ECE2010

Role of PKA regulatory subunit R2B in murine and human adipocyte differentiation

Ermetici Federica , Peverelli Erika , Mantovani Giovanna , Corbetta Sabrina , Avagliano Laura , Bulfamante Gaetano , Beck-Peccoz Paolo , Spada Anna

PKA regulatory subunit 2B (R2B) is the most expressed in mouse adipose tissue, where it plays an important role in regulating energy balance. We previously demonstrated that R2B is the most abundant R subunit in human adult subcutaneous and visceral adipose tissues. We further showed that R2B expression and PKA activation are reduced in adipose tissues from obese as compared to non-obese subjects. Normal adipose tissue development and increases in fat mass associated with obes...

ea0022oc1.6 | Diabetes and obesity | ECE2010

Variation in response to exercise in type 2 diabetes associated to VEGFA and PGC1-α expression

Wagner Henrik , Fischer Helene , Degerblad Marie , Bavenholm Peter , Efendic Suad , Gustafsson Thomas

Objective: The individual changes in insulin sensitivity in response to exercise demonstrate a large variation. The mechanisms contributing to improved insulin sensitivity by training in type 2 diabetes are not fully known but presumably involve both metabolic and structural adaptations. The present study investigates if associations exist between changes in expression of key genes and improved insulin sensitivity, VO2max and glycemic control following exercise trai...