Endocrine Abstracts

The use of targeted therapies such as Tyrosine kinase inhibitors is becoming a common strategy in several advanced cancers. Several tyrosine kinases are targeted by the drugs, and the anti-neoplastic actions involves both anti-proliferative and anti-angiogenesis effects. Initial case reports, have been followed by series reporting treatment induced thyroid dysfunctions. They include thyrotoxicosis and hypothyroidism sometimes with a biphasic course, reminiscent of silent subac...

Background: AIT type 2 is self-limiting in nature and therefore discontinuation of amiodarone may not be necessary; however, the feasibility of continuing amiodarone has never been tested formally. Potassium perchlorate (KClO4) may have advantage when prednisone is unsuccessful in AIT type 2, possibly due to mixed cases of types 1 and 2. KClO4 also mitigates the cytotoxic effect of desethylamiodarone on thyrocytes in vitro.Ob...

Interferon-alpha (IFNa) is used for the treatment of various disorders, including chronic hepatitis C virus (HCV) infection and certain malignancies. One of the commonest side effects of IFNa therapy is thyroiditis, with up to 40% of HCV patients on IFNa developing clinical or subclinical disease. In some cases interferon induced thyroiditis (IIT) may cause complications such as atrial fibrillation resulting in discontinuation of therapy. IIT can manifest clinically as thyroto...