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12th European Congress of Endocrinology


Hypothalamic networks and energy homeostasis

ea0022s28.2 | Hypothalamic networks and energy homeostasis | ECE2010

Brain lipogenesis and the control of food intake: the lipostatic hypothesis revisited

Lopez Miguel

The ‘classical’ hypothalamic neuropeptide view of feeding regulation has been extensively reviewed and revised during the last few years. Accumulating evidence indicate that pharmacological and genetic modulation of lipogenesis de novo in the hypothalamus, through selective pharmacologic and genetic manipulation of acetyl-CoA carboxylase (ACC), AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase-1 (CPT1), fatty acid synthase (FAS) and malonyl-C...