Endocrine Abstracts (2010) 22 P371

Effects of lambda-cyhalothrin on hematological parameters and testicular functions in male rat

Mosbah Rachid1, Boulakoud Mohamed Salah2 & Yousef Ibrahim Mokhtar3

1Department of Biology/Faculty of Sciences, University of Boumerdes, Boumerdes, Algeria; 2Department of Biology/Faculty of Sciences, University of Badji Mokhtar-Annaba, Annaba, Algeria; 3Department of Home Economic, Faculty of Specific Education, University of Alexandria, Alexandria, Egypt.

Lambda-cyhalothrin is a potent synthetic type II pyrethnoid used worldwide to control a wide range of insects in agriculture, forestry, human health, and home. The purpose of this study is to investigate the effects may occur on hematological and testicular functions by this pesticide. Two groups of wistar rats were used, the first group served as control and the second experimental was received an emulsion solution of Lambda-cyhalothrin by orale route at dose of 23 mg/kg during 7 days. Blood samples were collected for measuring hematological parameters. Testes and epididymes were removed for measuring semen quality and histology. Our results showed that the insectide Lambda-cyhalothrin decreased significantly the body weight (BW), and relative weight of testes (RWT), seminal vesicles (RSV) and epididymes (RWE), whereas, weights of liver (LW), kidney (KW) and adrenal (AW) were augmented. Hematological analysis, revealed a reduction in red blood cells (RBC) count, hemoglobin concentration (Hb) and in packed volume cell percent (PVC); while, the leucocytes (WBC) count was increased. Also, the pesticide, altered the semen quality by a reduction in spermatids number (SN), sperm count (SC) and mobility; While, dead and abnormal sperm were increased. The histological examinations of testes of treated rats shows testicular damage characterized by alteration of spermatogenesis, degeneration of the germinal epithelium with presence of the apoptotic cells and absence of the spermatozoids in certain lights. Thus, it may be concluded that lambda-cyhalothrin can altered hematological parameters, testicular functions and fertility in rat.

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