Endocrine Abstracts (2010) 22 P715

Relation of weight, height and BMI of child to parental characteristics in families with obese or overweight parents before weight management: diogenes project

Marie Kunesova1, Petr Hlavaty1, Pavla Kalouskova1, Magda Bajzova1, Karolina Hlavata1, Martin Hill1, Wim Saris2 & Arne Astrup3

1Obesity Centre, Institute of Endocrinology, Prague, Czech Republic; 2Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; 3Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Familial resemblance was shown for body composition and risk factors in several studies. In twin studies which are powerful tool to assess genetically mediated traits significant resemblance was found in twins reared apart. In pairs of monozygotic twins was found significant resemblance in response to positive and negative energy balance. Aim of the study was to evaluate relationship of anthropometric parameters of parents and socioeconomic characteristics of family to weight, height and BMI of their children.

Methods: In families participating in the multicentric paneuropean project DIOGenes (Diet, Obesity and GENES) families with both parents being obese or overweight were examined. Resemblance of anthropometric variables between parents and their child participating in the study was assessed before start of weight management programme. Families with at least one obese or overweight parent and at least one child aged 6–18 years from 8 European countries were participating in the Diogenes project. For assessment of familial resemblances 99 families in which both parents entered the study were selected. Anthropometric characteristics of subjects (weight, height, waist and hip circumferences) were measured, BMI and waist to hip ratio was calculated. Body composition was examined by DEXA or by bioelectrical impedance method. Anthropometric parameters of parents and socioeconomic characteristics of families were included into statistical analysis as independent variables. Multivariate regression with reduction of dimensionality (method of bidirectional orthogonal projections to latent structures) was used.

Results: Significant relationship between weight, height and BMI of child (dependent variables) and age of child, number of persons in family, height of father (positive correlation) and age of father at birth of child and age of mother at birth of child (negative correlation) was found. Variability shared between dependent and independent variables was 52.8% (49.1% after cross validation).

Conclusion: Weight, height and BMI of child is positively correlated with height of father and number of persons in family and negatively with age of parents at birth of child.

Supported by the European Community (Contract no. FP6-513946), http://www.diogenes-eu.org and by the grant of the IGA of Ministry of Health CR No. IGA NS/9830-4.

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