Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

ea0022p670 | Obesity | ECE2010

Impact of sarcopenia on metabolic profile in sarcopenic-obese post menopausal women?

Fex Annie , Leheudre Mylene Aubertin , Karelis Antony , Filion Marie Eve , Dionne Isabelle J

Background: Menopause is associated to body composition transformations, such as an increase in total fat mass (obesity), central fat mass and a decrease in lean body mass (sarcopenia). Body fat distribution also changes with age, with an increase in visceral abdominal fat and a decrease in subcutaneous abdominal fat. Moreover, an increase in visceral fat may lead to increase the secretion of pro-inflammatory adipokines that further promote insulin resistance as well as potent...

ea0022p671 | Obesity | ECE2010

Metabolic surgery (gastric bypass) has no ‘magical effect' in severely obese patients with type 1 diabetes

Mlawa Gideon , Deshmukh Sandeep , Eboh Cecil , Nasruddin Asrai , Sharp Patrick

Background: Metabolic surgery has been hailed as a potential new treatment (‘magic bullet’) for obese patients with type2 diabetes. Several studies have shown that metabolic surgery for morbid obese patients with type2 diabetes can lead to considerable weight loss and also has positive impact on the incidence of type2 diabetes, in some cases leading to elimination of the disease in up to 80% of patients. But metabolic surgery do not seem to induce similar ‘magic...

ea0022p672 | Obesity | ECE2010

Testosterone gel significantly increase lean body mass in ageing males with relatively low bio-available testosterone and waist circumference above 94 cm: a double blinded, randomized, placebo controlled 6 months study

Frederiksen Louise , Hougaard David M , Brixen Kim , Andersen Marianne

Background: Testosterone replacement therapy in severe hypogonadism is indicated, however, the treatment of late onset hypogonadism (LOH) is debated, especially what the diagnostic criteria should be. In LOH bio-available testosterone probably gives a more accurate index of gonadal status as a diagnostic criterion as it takes SHBG into consideration. SHBG is known to increase with ageing, however, SHBG is also negatively influenced by insulin and visceral adiposity.<p clas...

ea0022p673 | Obesity | ECE2010

Ghrelin basal levels in people with abdominal obesity

Charnysh Olga , Mokhort Tatiana

Study objective: To study the differences of ghrelin basal levels (BG) among people with abdominal obesity.Materials and methods: One hundred and twenty-two patients aged 35–55 with obesity and 28 practically healthy persons (control group) were examined. The groups were identical in the sex and age, obesity. The BG levels in serum were measured by the immune-enzyme method with «DRG International» reagents.Results: A...

ea0022p674 | Obesity | ECE2010

Osteocalcin and the metabolic syndrome

Oros Sabina , Ianas Olga , Rosca Roxana , Vladoiu Suzana , Manda Dana , Dumitrache Constantin

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

ea0022p675 | Obesity | ECE2010

Relationship between obesity and classic cardiovascular risk factors

Gomez-Barrado Jose Javier , Polo Jose , Gomez-Martino Juan Ramon , Barquilla Alfonso , Vega Jorge , Turegano Soledad , Gallego Rocio , Garciperez de Vargas Francisco Javier

Obesity is a disease very prevalent and often associated with morbidities and cardiovascular risk factors. We explore the relationship between the presence of obesity with cardiovascular risk factors more frequent and the presence of cardiovascular disease (CVD) after (ischemic heart disease, cerebrovascular disease, peripheral artery).Material and methods: A sample of 1491 individuals of both sexes, over 14 years, elected by random sampling three of the...

ea0022p676 | Obesity | ECE2010

Pathological types of the family education as the risk factor of the childhood obesity

Vishnevsksaya Mariya , Solnceva Anjelika

There are limited numbers of studies concerning family education as a risk factor for obesity in children. We aimed to examine the relationship between a children’s weight and family/psychosocial factors, to establish gender differences in eating behavior in obese children.Materials and methods: This cross-sectional study involved 65 obese children (m/f=33/32, mean age 13.5±0.5 years) and 65 mothers. Obesity was defined as BMI scores at ...

ea0022p677 | Obesity | ECE2010

TSH levels in overweight and obese euthyroid subjects with metabolic syndrome

Golubovic Milena Velojic , Dimic Dragan , Stojic Danijela , Radenkovic Sasa , Antic Slobodan

Objectives: There are reports which suggests that TSH levels are independetly associated with components of metabolic syndrome. The aim of this study was to investigate the relatinship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in owerweight and obese euthyroid subjects.Methods: In 80 euthyroid owerweight and obese subjects, 44 women and 36 man, fasting blood semples were analyzed for glucose, triglycerides and HDL and estima...

ea0022p678 | Obesity | ECE2010

Complementary and alternative treatment approaches in obese patients: a cross-sectional study

Kilic Unal , Geyik Ozlem , Oguz Ayten , Balkan Fevzi , Ersoy Reyhan , Cakir Bekir

Introduction: Effective conventional medical treatments for obesity are limited and patients with obesity seeking alternative forms of health care for weight loss. While several previous studies have examined patterns of complementary and alternative treatment (CAT) use in different populations, limited data are available on the relationship between obesity and use of CAT. In this cross-sectional study, we aimed to overview the alternative therapy methods in obese patients.</p...

ea0022p679 | Obesity | ECE2010

Differential expression of proteins in omental and subcutaneous adipose tissue

Insenser Maria , Montes Rafael , Simo Rafael , Vendrell Joan , Escobar-Morreale Hector F

Background: Adipose tissue is considered a highly active metabolic and endocrine organ with important physiological functions. The evaluation of protein expression has the potential advantage of providing a global vision of the cellular pathways associated with adipose tissue dysfunction and obesity, permitting the identification of novel candidate molecules that would have not been considered of interest otherwise.Objectives: To identify proteins differ...

ea0022p680 | Obesity | ECE2010

Relationship between the breast cancer and abdominal obesity

Tuncbilek Nermin , Guldiken Sibel , Okman Tulay Kilic , Sezer Atakan , Altaner Semsi , Mentes Asli , Ozdemir Huseyin

Purpose: Numerous epidemiological studies have shown that obesity is a risk factor for postmenopausal breast cancer and relapse. We aim to investigate the relation between the upper abdominal obesity and breast cancer, by using ultrasonography (USG).Material and methods: The study population consisted of 44 women in control group and 17 breast cancer patient in study group. In the whole study population fat tissue was measured with high resolution B-mode...

ea0022p681 | Obesity | ECE2010

The Moscow study: a randomized, placebo-controlled, double-blind trial of parenteral testosterone undecanoate on the metabolic syndrome components and body composition

Tishova Yuliya , Kalinchenko Svetlana , Mskhalaya George , Saad Farid , Gooren Louis J G , Giltay Erik J

Background: Metabolic syndrome has a high prevalence in male population, leading to the high rate of cardiovascular disease and mortality. Numerous studies show that low androgen levels in men are associated with the metabolic syndrome. This study tested whether normalization of testosterone levels improves metabolic dysregulations and body composition.Methods: In a randomized, placebo-controlled, double-blind, phase III trial ( identif...

ea0022p682 | Obesity | ECE2010

Effects of parenteral testosterone undecanoate administration on inflammatory markers: the Moscow study

Kalinchenko Svetlana , Tishova Yuliya , Mskhalaya George , Saad Farid , Gooren Louis J G , Giltay Erik J

Background: Numerous studies (among which, studies of androgen deprivation in men with prostate cancer) show that low androgen levels in men are associated with the metabolic syndrome. Obesity and particularly visceral fat excess is associated with pro-thrombotic and pro-inflammatory states as well. This study tested whether normalization of testosterone levels improves markers of inflammation.Methods: In a randomized, placebo-controlled, double-blind, p...

ea0022p683 | Obesity | ECE2010

Visceral fat accumulation as a risk factor for the carotid plaque occurrence in ischemic stroke patients

Guldiken Baburhan , Tuncbilek Nermin , Guldiken Sibel , Durmus Yavuz , Hunkar Remziye , Ozdemir Huseyin , Ture Mevlut , Turgut Nilda , Demir Kemal

Aim: The present study aimed to investigate the relationship of visceral fat accumulation with the existence of the carotid plaque in ischemic stroke patients.Materials and methods: Seventy patients (37 male, 33 female) with acute ischemic stroke were enrolled in the study. The carotid IMT and the existence of carotid plaque of the patients were evaluated by high resolution ultrasonography with a 7.5 MHz linear superficial array probe in B-mode. The abdo...

ea0022p684 | Obesity | ECE2010

Relation of PPARγ genetic polymorphism and testosterone levels in males with metabolic syndrome

Stankiewicz-Olczyk Joanna , Bolanowski Marek

Obesity and overweight are nowadays very important health problems. Metabolic syndrome increases the risk of diabetes mellitus and coronary heart disease. Patients suffering from metabolic syndrome, especially males, are at greater risk of acute cardiovascular episodes, like heart infarct or brain stroke, than patients without this, widely accepted atheromatosis’ risk farctor. The aim of the study was assessment of possible relations of PPARγ genetic polymorphism and...

ea0022p685 | Obesity | ECE2010

The effects of orlistat on weight, serum lipids, blood pressure and fasting plasma glucose in obese patients with prediabetes

Pejicic Snjezana , Pejicic Anja , Dunovic Severin

Orlistat selectively inhibits gastrointestinal lipase, thereby preventing fat dissolution and reducing fat absorption. Many studies have shown good effect of Orlistat on parameters of metabolic syndrome and diabetes mellitus type 2.The aim of this study was to examine the effect of Orlistat on:body mass reduction, serum lipid level, blood pressure level, fasting plasma glucose level (FPG) by obese patients with prediabetes.Study in...

ea0022p686 | Obesity | ECE2010

Increased oxidative damage to lipids and DNA in overweight and obese patients

Szosland Janusz , Kokoszko Agnieszka , Zasada Krzysztof , Stepniak Jan , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Introduction: Obesity does constitute one of the most common modifiable risk factors for cancer. The process of cancerogenesis is associated with the enhanced oxidative stress. Lipid peroxidation (LPO), resulting from oxidative damage to membrane lipids, as well as oxidative damage to DNA, are the most frequently examined processes to evaluate oxidative damage to macromolecules.Aim: The aim of the study was to evaluate the level of oxidative damage to me...

ea0022p687 | Obesity | ECE2010

Glucagon stimulates cholecystokinin secretion in humans

Arafat Ayman , Otto Barbel , Adamidou Aikaterini , Spranger Joachim , Weickert Martin , Mohlig Matthias , Pfeiffer Andreas

Objectives: Gastrointestinal hormones are known to modulate satiety. The mechanisms underlying the impact of glucagon on satiety are so far unknown. However, it can be postulated that the glucagon-induced reduction in hunger feeling is mediated through changes in Cholecystokinin (CCK), which is known to play a role in meal termination. It was the aim of the present study to evaluate the impact of glucagon on CCK and the modulation of these effects in obesity.<p class="abst...

ea0022p688 | Obesity | ECE2010

Early genetic rescue of extremely obese POMC-deficient mice is critical for successful recovery of normal feeding behavior and body weight

Bumaschny Viviana , de Souza Flavio , Rodriguez Vanina , Low Malcolm , Rubinstein Marcelo

A major difficulty of obesity treatments is that patients stop losing weight after a period of responsiveness and often experience a rebound. This could be caused by an impairment in energy balance circuits that becomes irreversible as obesity progresses. To test this hypothesis, we generated a reversible knockout-mouse model of early onset obesity. These mice are unable to express the proopiomelanocortin gene (Pomc) in hypothalamic neurons (CNS-Pomc−/...

ea0022p689 | Obesity | ECE2010

Influence of age of onset of metabolic syndrome

Gomez-Barrado Jose Javier , Gomez-Martino Juan Ramon , Polo Jose , Barquilla Alfonso , Turegano Soledad , Vega Jorge , de Vargas Francisco Javier Garciperez , Mendoza Javier

The metabolic syndrome (MS) is a pathological entity that carries a high cardiovascular risk, and whose risk factors may occur at an early age. No data are available in our area on the influence of age on the prevalence of MS.Objectives: To determine the prevalence of MS in our area, by age group and compare the frequency of occurrence of MS in young adults (<40 years) (J) and mature adults (>40 years) (M).Methods: Observat...

ea0022p690 | Obesity | ECE2010

Serum fibroblast growth factor 21 in human obesity: regulation by hyperinsulinemia and relationship with glucose and lipid oxidation

Straczkowski Marek , Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Lebkowska Agnieszka , Otziomek Elzbieta , Gorska Maria , Kowalska Irina

Fibroblast growth factor 21 (FGF21) might increase glucose uptake in adipocytes and reduce plasma glucose and triglycerides in animal models of diabetes. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation. We examined 76 subjects with normal glucose tolerance, 36 lean (BMI <25 kg/m2) and 39 overweight or obese...

ea0022p691 | Obesity | ECE2010

Predictive factors for a good response to antidepressant pharmacotherapy in patients with metabolic syndrome

Vija Lavinia , Oros Sabina , Dragomir Adina , Iconaru Laura , Gudovan Emilia , Boanta Catalina , Dumitrache Constantin

Objectives: Metabolic syndrome, especially obesity and diabetes are associated and responsible for a depressive psychological status. Meanwhile, antidepressors are responsible for metabolic disturbances, such as insulin resistance. The study aims to determine predictive factors of response to antidepressant pharmacotherapy in patients with metabolic syndrome.Materials and methods: A retrospective study conducted in Institute Parhon’s Department for ...

ea0022p692 | Obesity | ECE2010

Assessment of correlations between IL-18, CRP and selected adrenal androgens serum levels according to the anthropometrical and biochemical indices of metabolic syndrome (MS) in ageing men

Herman Waldemar , Lecka Katarzyna , Kaufman Elzbieta , Wojcicka Marlena , Kramer Lucyna , Losy Jacek

Aims: The aim of our study was to assess the relationships between systemic markers of general inflammation: interleukin 18 (IL-18) and C-reactive protein (CRP) and dehydroepiandrosterone (DHEA) as well as dehydroepiandrosterone sulphate (DHEA-S) serum levels, in addition to the anthropometrical and biochemical indices of metabolic syndrome (MS) in men over the age of 40.Patients and methods: In 271 randomly chosen men aged 40 to 80 years living in Lubus...

ea0022p693 | Obesity | ECE2010

The obese phenotype is associated with more severe autoimmune thyroiditis evolving towards primary hypothyroidism

Ciampolillo Anna , De Pergola Giovanni , Tarantino Lucia , Trerotoli Paolo , Giorgino Francesco

Autoimmune thyroiditis is a common disease with different clinical aspects. It has not been established whether a rapid cellular destruction, with evolution towards hypothyroidism, may be associated with specific clinical phenotypes. To clarify this point, we studied 386 consecutive patients affected by autoimmune thyroiditis diagnosed within the previous 3 years: 193 patients (170 female and 23 males, age range 57.5±12.8, Group 1) were treated with L-thyro...

ea0022p694 | Obesity | ECE2010

Reference interval values of four plasmatic endocannabinoids measured by isotopic dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)

Fanelli Flaminia , Cuomo Gaia , Di Lallo Valentina Diana , Belluomo Ilaria , Baccini Margherita , Gambineri Alessandra , Vicennati Valentina , Pasquali Renato , Pagotto Uberto

The endocannabinoid system is involved in modulating many metabolic and behavioural processes. Due to the instable nature of endocannabinoids in biological fluids and to the poor sensitivity of traditional analytical technologies, little is known about physiological circulating levels of these lipid mediators. We developed and validated an ID-LC-MS/MS method for the simultaneous measurement of four endocannabinoids: anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoyl-et...

ea0022p695 | Obesity | ECE2010

The metabolic syndrome and the non-alcoholic fatty liver disease: metabolic and pathology aspects

Popescu Mihaela , Popescu Alin , Neagoe Daniela , Comanescu Violeta , Dinca Mihaela , Bistriceanu Marian

Obesity and the metabolic syndrome show increased morbidity and mortality, by inducing morphological and functional alterations of several organs, the liver included (non-alcoholic fatty liver disease – NAFLD). They start with minimal alterations ranging to terminal liver disease (non-alcoholic steatohepatitis – NASH – and cirrhosis).We intended to identify the histological aspects in NAFLD and to examine the correlations between the histo...

ea0022p696 | Obesity | ECE2010

Obesogenic environmental risk factors in Belarusian preschool children

Viazova Liudmila , Solntsava Anshalika , Sukalo Alexander , Maitak Michail

Background: Manifestation of early age adiposity raises complicated forms of obesity and risks for concomitant diseases development.Objective: To detect obesogenic risk factors in preschool children screening study.Material and methods: Of 1008 children from 8 Minsk kindergartens were screened. Anthropometrical parameters, systolic and diastolic blood pressure (SBP and DBP) were measured. Body mass index (BMI) standardized for age ...

ea0022p697 | Obesity | ECE2010

Waist circumference does not reflect body fat distribution and insulin resistance in young male patients with idiopathic hypogonadotrophic hypogonadism

Aydogdu Aydogan , Kucukerdonmez Ozge , Uckaya Gokhan , Taslipinar Abdullah , Bolu S Erol , Sonmez Y Alper , Aydogan Umit , Kutlu Mustafa

Hypogonadism is associated with increased body fat content and insulin resistance. Many associations including ADA, IDF and EASD declare that waist circumference is a reliable measure of visceral adiposity and may account for insulin resistance. Our observations in young male patients with idiopathic hypogonadotrophic hypogonadism (IHH) are opposite. Thus, we aimed to compare body fat content and anthropometric measurements between patients and age-matched eugonadal healthy co...

ea0022p698 | Obesity | ECE2010

Abdominal fat, insulin sensitivity, inflammatory atheromatosis risk factors and polymorphisms of 174-G/C IL-6 promoter and Pro12Ala PPARγ in non-obese subjects

Bednarek-Tupikowska Grazyna , Kubicka Eliza , Tworowska-Bardzinska Urszula , Laczmanski Lukasz , Bolanowski Marek , Milewicz Andrzej

Some individuals with normal weight but probably visceral fat excess, called Metabolically Obese Normal-Weight (MONW), have disturbances typical for metabolic syndrome. We analyzed relationships between body fat distribution (estimated by DXA) and insulin resistance, serum inflammatory markers levels (CRP, IL-6, IL-18) and polymorphisms of IL-6 promoter and PPARγ in healthy, non-obese Polish subjects: 232 women (age 31.4±5.5; BMI 21.5±2.5) and 199 men (age 30.3&...

ea0022p699 | Obesity | ECE2010

FTO gene haplotypes are associated with GH levels in lean women

Lukasova Petra , Vcelak Josef , Vankova Marketa , Bradnova Olga , Kvasnickova Hana , Bendlova Bela

Background and aims: The fat mass and obesity associated gene (FTO) was identified as a gene with strong obesity related traits nevertheless the exact mechanism is still unknown. Our aim was to study the possible effects of FTO risk haplotype on anthropometric data and metabolic and hormonal parameters in lean women (to eliminate the influence of BMI) and to evaluate the effect of hormone contraception (HC).Materials and methods: The SNPs r...

ea0022p700 | Obesity | ECE2010

Obesity and malnutrition are associated with different inflammation patterns in rats

Stevanovic Darko , Micic Dragan , Sumarac-Dumanovic Mirjana , Nesic Dejan , Popovic Vera , Starcevic Vesna , Trajkovic Vladimir

The inflammatory response in rat models of obesity and malnutrition was examined. Rats received standard chow (control), chow enriched with 30% lard (obese) or 70, 50, 40 and 40% of expected food intake weekly for 4 weeks (starved). The serum levels of cytokines were determined by ELISA, while the expression of cytokine mRNA in heart and liver was analyzed by real-time RT-PCR. The blood concentrations of pro-inflammatory cytokines (TNF, IL-1) and Th1 cytokine IFN-gamma were si...

ea0022p701 | Obesity | ECE2010

The circulating pattern of adiponectin and resistin in critically ill patients with sepsis

Vassiliadi Dimitra , Tzanela Marinella , Dimopoulou Ioanna , Orfanos Stylianos , Kotanidou Anastasia , Armaganidis Apostolos , Tsagarakis Stylianos

Several alterations of the metabolic processes develop during sepsis. Adiponectin and resistin are amongst the main adipokines that may contribute to the metabolic adaptations observed in the context of critical illness. However, there is scarce data on the circulating pattern of these adipokines in human sepsis. Therefore we aimed to describe the variation in circulating levels of resistin and adiponectin during the course of sepsis and examine whether they are related to the...

ea0022p702 | Obesity | ECE2010

Acylated, unacylated ghrelin and obestatin regulation during oral glucose tolerance test in obese prepubertal and pubertal children

Prodam Flavia , Bellone Simonetta , Petri Antonella , Trovato Letizia , Genoni Giulia , Dondi Elena , Demarchi Irene , Bona Gianni

Physiological role of acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin is poorly understood especially in childhood. To understand their biological implications in obesity and metabolic syndrome (MS), we measured AG, UAG, obestatin, at fasting and every 60′ during oral glucose tolerance test (OGTT) in 60 prepubertal (PP–OB; 32) and pubertal (P-OB; 28) children. Paediatric IDF 2007 criteria was used to identifying MS. In PP-OB group, 20 (62.5%) children ...

ea0022p703 | Obesity | ECE2010

Melanocortin-4 receptor gene polymorphism (rs12970134) influences glucose metabolism, leptin and GH levels in women

Bradnova Olga , Vankova Marketa , Lukasova Petra , Vcelak Josef , Kvasnickova Hana , Bendlova Bela

Melanocortin-4 receptor (MC4R) gene is expressed in the brain and has been implicated in mediating most of the effects of melanocortin on food intake and energy expenditure. Common variants of MC4R gene are associated with fat mass, weight, risk of obesity and insulin resistance in several populations.We investigated if rs12970134 A/G is associated with obesity and studied its possible metabolic effects.Polymorphism was assesed by ...

ea0022p704 | Obesity | ECE2010

Vitamin D levels in obese patients with and without metabolic syndrome

Karatas Savas , Hekimsoy Zeliha , Dinc Gonul , Onur Ece , Ozmen Bilgin

Vitamin D role is not only associated with mineral metabolism and bone health but also in globally important diseases such as obesity and metabolic syndrome. The aims of this study were to investigate: i) 25(OH) vitamin D levels in obese patients with and without metabolic syndrome and compare these with levels in healthy subjects, ii) the relationship between serum 25(OH) vitamin D levels and metabolic syndrome components such as body mass index, waist circumference, blood pr...

ea0022p705 | Obesity | ECE2010

Relation of waist line radius and subcutaneous adipose tissue thickness positively correlates with markers of impaired glycemic control

Ristic Petar , Andjelkovic Zoran , Cizmic Milica , Dragovic Tamara , Kuzmic Snezana , Djuran Zorana , Karajovic Jelena , Kikovic Sasa , Tavcar Ivan

Introduction: Tendency to store lipids centrally is well connected to development of diabetes mellitus type 2 (T2DM) and cardiovascular morbidity. Providing insight in this process is important.Method: Relationship between radius of waist line and thickness of subcutaneous adipose tissue (SAT) was compared among forty obese patients (BMI> 30 kg/m2) in the light of their glycemic control parameters (fasting glucose, HOMA IR, HOMA beta).Pati...

ea0022p706 | Obesity | ECE2010

The influence of weight-loss induced by bariatric surgery on serum concentrations of novel metabolic regulators FGF-21 and FGF-19 in morbidly obese subjects

Haluzikova Denisa , Bartlova Marketa , Mraz Milos , Lacinova Zdena , Krizova Jarmila , Kavalkova Petra , Trachta Pavel , Michalsky David , Kasalicky Mojmir , Haluzik Martin

Objective: Fibroblast growth factor 19 (FGF-19) and FGF-21 are novel metabolic regulators that improve insulin resistence and obesity in rodents. The objective of this study was to explore whether changes in serum concentrations of FGF-19 and FGF-21 contribute to positive metabolic effects of weight loss induced by surgical treatment of obesity – sleeve gastrectomy (SG).Methods: Serum concentrations of FGF-19 and 21, adiponectin, resistin, fatty aci...

ea0022p707 | Obesity | ECE2010

Complementary and alternative medicine use in patients with obesity: an anthropological approach

Aksoy Duygu Yazgan , Cinar Nese , Levendoglu Fuat , Canikli Yasemin , Yildiz Bulent Okan , Bayraktar Miyase , Usman Aydan , Ilbars Zafer

Introduction: Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. For most of CAM, there are key questions that are yet to be answered through well-designed scientific studies. Obesity is one of the chronic health disorders which is difficult to deal and most of the obese patients are unable to lose or keep weight with diet, exercise or...

ea0022p708 | Obesity | ECE2010

Prevalence of no insulin-resistance in morbidly obese patients

Fernandez-Garcia Diego , Manuel Garcia Almeida Jose , Sebastian-Ochoa Arantzazu , Madueno Francisco Tinahones

Progression of metabolic syndrome to diabetes is not easily predicted in patients with morbid obesity. We hypothesized that no insulin-resistance is more usual as we thought.Objective: Evaluate prevalence of no insulin-resistance status in patients with morbid obesity.Patients and method: The study was undertaken in 130 patients with a BMI of 53.93±6.67 kg/m2. The morbidly obese patients were divided into four group...

ea0022p709 | Obesity | ECE2010

Influence of metformin therapy on peripheral blood androgenes concentrations in young women with metabolic syndrome

Kuliczkowska-Plaksej Justyna , Bednarek-Tupikowska Grazyna , Stachowska Barbara , Filus Alicja , Trzmiel-Bira Anna , Milewicz Andrzej

Introduction: Insulin resistance (IR) and visceral obesity, elements of metabolic syndrome (MS), contribute to hyperandogenaemia and may lead to hirsutism and other signs of hyperandrogenism. Little is known about the influence of metformin therapy (MET) on hormonal profile in women with MS and IR without menstrual irregularity.Aim: To asses the influence of MET on sex steroids concentrations in young women with MS.Methods: The stu...

ea0022p710 | Obesity | ECE2010

Sideways in treatment of obese child: a personal experience

Dautovic Slavica

The prevalence of overweight children and adolescents is one of the most important public health challenges today. The impact of this early obesity extends into adulthood: increased mortality and morbidity from a variety of conditions and adverse socio-economic consequences. No single approach to the treatment of childhood overweight has been demonstrated to be more effective than another. Challenges faced in managing obese child is selecting the approach that will be adhered ...

ea0022p711 | Obesity | ECE2010

Limited weight loss with gastric banding in patients with craniopharyngeoma

Weismann Dirk , Pelka Theresia , Bender Gwendolyn , Muller Herrmann , Gebhardt Ursel , Thalheimer Andreas , Jurowich Christian , Fassnacht Martin , Allolio Bruno

While bariatric surgery is the most effective treatment strategy to maintain long-term weight-loss and to improve survival, it has not been shown, that bariatric surgery is as effective in craniopharyngeoma patients with hypothalamic obesity. We retrospectively analyzed weight loss and metabolic parameters in 7 craniopharyngeoma patients and 14 controls who underwent gastric banding surgery in five centers in Germany and Austria. The last before and the first patient after the...

ea0022p712 | Obesity | ECE2010

Desacyl–ghrelin as a protective factor for obesity

Veiga Luisa , Silva-Nunes Jose , Melao Alice , Oliveira Ana , Duarte Leone , Brito Miguel

Background: Although acyl–ghrelin has been considered essential for ghrelin’s GH-releasing activity, several recent in vitro studies have shown that desacyl–ghrelin exhibits biological activities on metabolism and proliferation of adipocytes, myocytes, cardiomyocytes, and myelocytes. The full desacyl–ghrelin biological activity still remains a matter of debate.Aims: To assess desacyl–ghrelin circulating levels and its R51Q...

ea0022p713 | Obesity | ECE2010

Gastric inhibitory polypeptide (GIP) suppresses circulating ghrelin in humans: plasma metabolome based correlation network analysis for support of hormone-to- hormone interactions

Rudovich Natalia , Nikiforova Victoria J , Otto Baerbel , Pivovarova Olga , Gogebakan Ozlem , Weickert Martin O , Nauck Michael A , Pfeiffer Andreas F H

Aims: We investigate the influence of GIP on ghrelin secretion in normal glucose tolerant individuals with the use of the firstly applied correlation network analysis on human plasma metabolome data.Methods: To address this issue, we employed a GIP-infusion test and euglycemic- and hyperglycemic glucose clamp experiments combined with infusion of GIP or placebo in a cross-over manner in non diabetic obese male subjects (n=14). Moreover, we firstly...

ea0022p714 | Obesity | ECE2010

Effects of breastfeeding on maternal appetite-regulating hormones

Vila Greisa , Hopfgartner Judith , Grimm Gabriele , Riedl Michaela , Baumgartner-Parzer Sabina , Kautzky-Willer Alexandra , Clodi Martin , Luger Anton

Gestational weight gain has been linked to obesity in women of childbearing age. Mothers who breastfeed present less postpartum weight retention. The underlying pathophysiological mechanisms are unknown. This study aimed at investigating the impact of breastfeeding on maternal appetite-regulating hormones.The clinical trial recruited 29 women divided in three age- and BMI-matched groups. The first group included 10 fully breastfeeding mothers of 3 to 6 m...

ea0022p715 | Obesity | ECE2010

Relation of weight, height and BMI of child to parental characteristics in families with obese or overweight parents before weight management: diogenes project

Kunesova Marie , Hlavaty Petr , Kalouskova Pavla , Bajzova Magda , Hlavata Karolina , Hill Martin , Saris Wim , Astrup Arne

Background: Familial resemblance was shown for body composition and risk factors in several studies. In twin studies which are powerful tool to assess genetically mediated traits significant resemblance was found in twins reared apart. In pairs of monozygotic twins was found significant resemblance in response to positive and negative energy balance. Aim of the study was to evaluate relationship of anthropometric parameters of parents and socioeconomic characteristics of famil...

ea0022p716 | Obesity | ECE2010

Childhood obesity surveillance initiative in the Czech Republic: the association between BMI and school environment

Braunerova Radka , Kunesova Marie , Prochazka Bohumil , Vignerova Jana , Parizkova Jana , Steflova Anna , Wijnhoven Trudy , Riedlova Jana , Zamrazilova Hana

Objective: Prevalence of childhood obesity has been increasing steadily. Unfortunately, only a small number of European countries have functional system to monitor this problem. Since it is very important to have comparable data on the international level, Childhood obesity surveillance initiative has been established by WHO Europe in 2006. The objective of the initiative is to monitor prevalence of obesity and factors related to obesity among children (nutrition habits, physi...

ea0022p717 | Obesity | ECE2010

Characterisation of serum and glucocorticoid-induced kinase 1 in adipose tissue

Vila Greisa , Kiefer Florian , Reiter Marie Helene , Zeyda Maximilian , Stulnig Thomas M , Luger Anton

Serum and glucocorticoid-induced kinase 1 (Sgk1) is an early transcriptional target of glucocorticoids with antiapoptotic effects. Sgk1 becomes active after phosphorylation by growth factors such as insulin and IGF1 through the PI3 kinase/PDK1 pathway. Activated Sgk1 increases the cellular uptake of glucose by increasing the membrane abundance of glucose transporters GLUT1 and GLUT4. Here we present data on the expression and regulation of Sgk1 in adipose tissue using three di...

ea0022p718 | Obesity | ECE2010

Carbohydrate metabolism in obese women: association with the circulating levels of adiponectin and retinol binding protein-4

Silva-Nunes Jose , Melao Alice , Oliveira Ana , Duarte Leone , Brito Miguel , Veiga Luisa

Background: Adiponectin is an adipokine with anti-diabetic properties. Recently, retinol binding protein-4 (RBP4) was identified as an adipokine associated with insulin resistance (IR) and a potential marker for type 2 diabetes (T2D) development.Aims: To compare adiponectin and RBP4 circulating levels according to presence/absence of diabetes/prediabetes, in obese women. To study the degree of association of those adipokines with indexes of IR and insuli...

ea0022p719 | Obesity | ECE2010

Lindaxa effectiveness in obesity treatment associated with IGT and arterial hypertension

Ismailov S I , Kahlimova Z Yu , Narimova G D , Safarova Sh M

This research was designed to estimate effectiveness and safety of Lindaxa in treatment of obesity associated with IGT and arterial hypertension. Thus, 20 women (mean age 37.9 years-old) were treated with complex therapy including traditional therapy (diet, physical exercises, dhydration, metabolic and symptomatic treatment) including Lindaxa with dosage of 10–15 mg/day once daily during 6 months. Physical exercises were determined individually according to BMI and metabo...