ECE2010 Poster Presentations Thyroid (122 abstracts)
Parvovirus B19 infection: a possible role in autoimmune thyroid diseases
Etienne Justinien 1 , Christine Pannier 2 , Cyril Page 3 , Christine Segard 2 , Vladimir Strunski 3 , Henri Sevestre 4 , Gilles Duverlie 2 & Rachel Desailloud 1
1Endocrinology Unit, University Hospital, Amiens, France; 2Virology Unit, University Hospital, Amiens, France; 3Oto-Rhinolaryngology Unit, University Hospital, Amiens, France; 4Pathology Unit, University Hospital, Amiens, France.
Introduction: Autoimmune thyroid disease (AITD) is a common disease. It arise due to interactions between genetic background and environmental factors. However this interactions remain unclear. As it induces other autoimmune diseases, parvovirus is an attractive candidate.
Objective: To investigate the presence of parvoviral DNA in postoperative thyroid tissues.
Materials and methods: We collect prospectively postoperative thyroid specimens and serum samples from 90 patients. We investigate presence of IgG antibodies on serum samples (IgG Parvovirus B19 – Biotrin). Presence of parvoviral genome sequences in thyroid was investigated by real-time PCR (Artus* ParvoB19 TM PCR Kit – Qiagen) in serum samples and in thyroid specimens of patients, who were IgG positive (which prove a contact with parvovirus).
Results: Thirty-three patients were IgG positive. Parvoviral DNA detection was positive in 6 out of the 33 thyroid specimens. Only 1 serum sample was DNA positive out of these 6 patients. Final diagnosis was Grave’s disease in 3 out of 6 ‘DNA parvoviral positive’patients (50%) and in 3 out of 27 ‘DNA parvoviral negative’ patients (11.1%) (P=0.08). Lymphocytic infiltration was observed in 5 out of the 6 ‘DNA parvoviral positive’ patients (83.3%) and in 9 out of the 27 ‘DNA parvoviral negative’patients (33.3%) (P=0.08). Two serum samples were DNA positive out of these 27 patients.
Conclusion: DNA parvoviral presence in thyroid tissue is observed and is not due to viremia. This study suggests a possible relation between Grave’s disease, thyroid lymphocytic infiltration and parvovirus infection. Further study are needed to confirm these results.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more