Endocrine Abstracts (2010) 22 P795

Parvovirus B19 infection: a possible role in autoimmune thyroid diseases

Etienne Justinien1, Christine Pannier2, Cyril Page3, Christine Segard2, Vladimir Strunski3, Henri Sevestre4, Gilles Duverlie2 & Rachel Desailloud1

1Endocrinology Unit, University Hospital, Amiens, France; 2Virology Unit, University Hospital, Amiens, France; 3Oto-Rhinolaryngology Unit, University Hospital, Amiens, France; 4Pathology Unit, University Hospital, Amiens, France.

Introduction: Autoimmune thyroid disease (AITD) is a common disease. It arise due to interactions between genetic background and environmental factors. However this interactions remain unclear. As it induces other autoimmune diseases, parvovirus is an attractive candidate.

Objective: To investigate the presence of parvoviral DNA in postoperative thyroid tissues.

Materials and methods: We collect prospectively postoperative thyroid specimens and serum samples from 90 patients. We investigate presence of IgG antibodies on serum samples (IgG Parvovirus B19 – Biotrin). Presence of parvoviral genome sequences in thyroid was investigated by real-time PCR (Artus* ParvoB19 TM PCR Kit – Qiagen) in serum samples and in thyroid specimens of patients, who were IgG positive (which prove a contact with parvovirus).

Results: Thirty-three patients were IgG positive. Parvoviral DNA detection was positive in 6 out of the 33 thyroid specimens. Only 1 serum sample was DNA positive out of these 6 patients. Final diagnosis was Grave’s disease in 3 out of 6 ‘DNA parvoviral positive’patients (50%) and in 3 out of 27 ‘DNA parvoviral negative’ patients (11.1%) (P=0.08). Lymphocytic infiltration was observed in 5 out of the 6 ‘DNA parvoviral positive’ patients (83.3%) and in 9 out of the 27 ‘DNA parvoviral negative’patients (33.3%) (P=0.08). Two serum samples were DNA positive out of these 27 patients.

Conclusion: DNA parvoviral presence in thyroid tissue is observed and is not due to viremia. This study suggests a possible relation between Grave’s disease, thyroid lymphocytic infiltration and parvovirus infection. Further study are needed to confirm these results.

Article tools

My recent searches

No recent searches.