Endocrine Abstracts (2010) 22 S23.1

Obesity: clinical manifestations and therapeutic: does the choice of diet make any difference?

Christos Mantzoros

Harvard Medical School, Boston, Massachusetts, USA.

Different diets have been used clinically and/or have been rigorously assessed in the context of clinical trials in the past several years. Relative efficacy in terms of weight loss and improvement of cardiovascular outcomes will be presented. In addition, recent data have emerged on the role of leptin in mediating the neuroendocrine response to long-term caloric derivation and will also be presented along with novel data on leptin resistance. Leptin, alone or in combination with amylin, emerges as a potentially useful adjunct to dietary interventions for weight loss in obese humans.

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