Searchable abstracts of presentations at key conferences in endocrinology
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38th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 1

ea0024oc1.1 | Oral Communications 1 | BSPED2010

Best Abstract Winner

Ng S M , Turner M A , Gamble C , Didi M , Newland P , Victor S , Manning D , Settle P , Gupta R , Abernethy L , Parkes L , Atkinson J , Weindling A M

Background: Low thyroid hormone concentrations in the first few weeks of life in preterm infants may be linked with poor neurodevelopment. We conducted a multi-centred randomised controlled trial of thyroxine (T4) supplementation in babies born under 28-weeks’ gestation (TIPIT study). A post hoc subgroup analysis was undertaken to examine brain growth and development.Methods: Seventy-eight infants received T4 supplementation an...

ea0024oc1.2 | Oral Communications 1 | BSPED2010

Growth Hormone Deficiency in children is associated with selective cognitive deficits

O'Reilly M , Webb E , Dale N , Salt A , Dattani M

Aims: Recent evidence suggests that Growth Hormone Deficiency (GHD) may be associated with cognitive impairment in adults. These findings are supported by neurobiological studies documenting the presence of GH receptors in many regions of the brain, including the hippocampus and the prefrontal cortex. However to date no comprehensive investigation of the cognitive sequelae of growth hormone deficiency in children has been undertaken. We aimed to determine the effect of GHD on ...

ea0024oc1.3 | Oral Communications 1 | BSPED2010

Semen cryopreservation in adolescent minors with cancer: a 10-year experience

Gan H W , Davar Z , Alexander S , Gomes S , Davies M , Salim R , Spoudeas H A

Background: Increased childhood cancer survival has resulted in an accruing adult cohort faced with potential infertility. Pre-treatment semen cryopreservation can protect reproductive capacity in adolescent minors, but continued unique legal, ethical and educational barriers prevent consistent service provision across the UK. The effect of pubertal maturation, disease and treatment on the ability to produce sperm also remains poorly defined in this cohort. We present our 10-y...

ea0024oc1.4 | Oral Communications 1 | BSPED2010

The Growth Hormone Receptor Exon 3 Deleted Polymorphism is Associated with Birth and Placental Weight

Padidela R , Bryan S , Abu-Amero S , Hudson-Davies R , Achermann J , Moore G , Hindmarsh P

In humans Growth Hormone Receptor (GHR) transcripts exist in two isoforms, the full-length (GHRfl) or exon 3 deletion isoform (GHRd3). Individuals with the GHRd3 isoform are associated with an increased response to recombinant human GH. The d3/fl-GHR polymorphism does not influence adult height. However, an association with the d3/fl-GHR polymorphism has been found with antenatal growth especially in small for gestational age (SGA) infants. H...

ea0024oc1.5 | Oral Communications 1 | BSPED2010

Factors affecting changes in insulin sensitivity and insulin secretion during Growth Hormone treatment in children born small for gestational age

Thankamony A , Jensen R B , O'Connell S , Kirk J M W , Donaldson M D C , Ivarsson Sten-A , Soder O , Hoey H , Juul A , Dunger D B

Background: Individuals born Small for Gestational age (SGA) are at high risk of development of type 2 diabetes. Growth hormone (GH) therapy can also adversely affect glucose metabolism.Aim: To explore the factors associated with changes in insulin sensitivity (IS) and insulin secretion during one year of GH treatment in children born SGA.Methods: In the NESGAS clinical trial, we studied 82 (55♂) pre-pubertal children (age 3....

ea0024oc1.6 | Oral Communications 1 | BSPED2010

Altered Metabolomic Profile in Children Born Small for Gestational Age without Post-Natal Catch-up Growth

Butcher I , Murray P , Brown M , Dunn W , Westwood M , Clayton PE

Background: Approximately 1000 children per annum born small for gestational age (SGA) will fail to catch-up and become eligible for GH treatment. The reason for this failed growth is often not defined. Understanding mechanisms that cause growth failure in SGA and finding potential biomarkers of poor growth is therefore important. We are using the new technique of Metabolomics as one avenue to address this. Metabolomics is the quantification of small molecule metabolites in a ...

ea0024oc1.7 | Oral Communications 1 | BSPED2010

Best Abstract Winner

Gaston-Massuet Carles , Andoniadou Cynthia , Signore Massimo , Jayakody Sujatha , Charolidi Nocoletta , Tissier Paul Le , Dattani Mehul , Martinez-Barbera Juan Pedro

Wnt/beta-catenin signalling pathway is required during embryonic development for normal cell proliferation, differentiation and for organ homeostasis in adulthood. Over-activation of this pathway has been implicated in human cancers such as colon or skin cancers. Here, we demonstrate that enhancement of the Wnt pathway in the embryonic Rathke’s pouch causes over-proliferation of progenitor cells and severe differentiation defects in the Pit1-lineage, which results ...

ea0024oc1.8 | Oral Communications 1 | BSPED2010

Clinical and Molecular Characterisation of 300 patients with Congenital Hyperinsulinism

Kapoor Ritika R , Flanagan Sarah E , Shield Julian P , Ellard Sian , Hussain Khalid

Background: Congenital hyperinsulinism (CHI) is a clinically heterogeneous condition. Mutations in seven genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1 and HNF4A) are known to cause CHI.Aim: To characterise the clinical and molecular aspects of a large cohort of patients with CHI.Methodology: 300 patients with biochemically confirmed CHI were recruited. Detailed clinical information was collected prior to geno...