Endocrine Abstracts

Background: Pump has become increasingly more popular amongst clinicians in the management of children with type 1 diabetes (T1DM). It improves the metabolic control in most patients though it may have a negative effect on growth. Eighty children with T1DM at our institute are currently treated with continuous subcutaneous insulin infusion (CSII) to achieve optimum glycaemic control.Aims: To identify the effect of CSII on hospital admissions, hypoglycaem...

Background: Adolescence is a time of change and is associated with a deterioration in glycaemic control. Education is an important part of diabetes care and enables patients to understand how to manage their condition. An audit was carried out to assess whether adolescents with type 1 diabetes were being educated about social aspects of diabetes.Method: Fifteen adolescents between the ages of 13 and 17 were asked to subjectively score their knowledge of ...

Background: Glucolipotoxicity contributes to declining B-cell function and acceleration of type 2 diabetes (T2DM). Intensive insulin therapy has been shown to rapidly reverse glucolipotoxicity and improve B-cell function, particularly if given soon after diagnosis. Recent trials in adults have shown promise, with 50% in remission at 1 year after intensive insulin therapy.Methods: We report 4 cases of young people with T2DM treated with intravenous insuli...

Introduction: Two insulin regimes are commonly used in type 1 diabetes (T1D): twice daily (BD) premixed insulin (short and intermediate acting), and multiple daily injections (MDI) of short acting insulin with once daily bolus of long acting insulin. MDI is associated with better glucose control in adults, but the evidence base is weaker for children.Objectives: We aimed to compare children started on MDI to BD from diagnosis, on HbA1c as a measure of gl...

Clinical trials of multiple dose insulin (MDI) or pump therapy (CSII) suggest a short term effect with a waning of effect over time – the ‘Hawthorn Effect’. This may relate to interest in the patient during the trial or to lack of reinforcement of the education and training programme. We reviewed our experience in this area where we have used a structured education programme for CSII and MDI over the last 6–8 years and used Quality Control Theory to explore...