Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2011

Oral Communications

Young Endocrinologists prize session

ea0025oc1.1 | Young Endocrinologists prize session | SFEBES2011

Thyroid hormones in the euthyroid range predict subsequent body mass composition in women: the OPUS study

Rao Preethi , Williams Graham , Murphy Elaine , Reid David , Roux Christian , Felsenberg Dieter , Gluer Claus , Eastell Richard , Razvi Salman

Background: Thyroid disease is associated with BMI with hyperthyroidism causing weight loss and hypothyroidism leading to weight gain. However, the relation of body weight distribution to thyroid function in euthyroid individuals is unclear. This study assessed body composition in euthyroid women.Methods: Euthyroid women (n=1072) from the Osteoporosis and Ultrasound Study (OPUS), a population based cohort study recruited participants from 5 Europe...

ea0025oc1.2 | Young Endocrinologists prize session | SFEBES2011

Does ‘mild' primary hyperparathyroidism progress if left untreated? A natural history study

Yu Ning , Donnan Peter , Smith David , Leese Graham

The prevalence of primary hyperparathyroidism (PHPT) is increasing and the majority (over 85%) are now asymptomatic and remain untreated. In order to know whether or not they can be left safely without surgery, issues on disease progression need to be addressed. We aimed to update the natural history of PHPT, with a focus of serum calcium progression in mild untreated patients, selected from a large pre-defined cohort of PHPT in Tayside, Scotland. Possible predictors of progre...

ea0025oc1.3 | Young Endocrinologists prize session | SFEBES2011

Prolonged exposure to GH impairs insulin signaling in the heart

Miquet Johanna G , Martinez Carolina S , Giani Jorge F , Gonzalez Lorena , Sotelo Ana I , Dominici Fernando P , Bartke Andrzej , Turyn Daniel

GH and IGF1 play an important role in cardiac development and function. Conditions leading to abnormal GH levels are associated with cardiovascular disease. Although acromegaly is associated with hypertension, insulin resistance, diabetes type 2 and dislipemia, several studies ascribe the heart alterations displayed by these patients to the direct action of chronically elevated GH and IGF1 levels.Given that insulin acts as a growth factor to the heart an...

ea0025oc1.4 | Young Endocrinologists prize session | SFEBES2011

Developing an in vitro model of tissue expansion in Graves ophthalmopathy: exploring the role of IGF1 receptor targeting as a novel treatment

Ezra Daniel , Rose Geoffrey , Bailly Maryse

Introduction: One of the most promising potential targets for new treatments in Graves ophthalmopathy (GO) is the insulin-like growth factor 1 receptor (IGF1R). However, a significant impediment to the translational pathway in developing new treatments for GO is the lack of any animal or in vitro model.Aims: To characterise dysregulation of IGF1 pathway related gene expression in GO. To develop a new in vitro model for tissue expansion in G...

ea0025oc1.5 | Young Endocrinologists prize session | SFEBES2011

Atheroprotection by 11β-HSD1 deficiency in ApoE−/− mice: role of both glucocorticoid and 7-oxysterol factors

Mitic Tijana , Hadoke Patrick W F , Chuaiphichai Surawee , Man Taq Y , Miller Eileen , Andrew Ruth , Walker Brian R , Chapman Karen E , Seckl Jonathan R

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active glucocorticoids thus amplifying their intracellular actions. 11β-HSD1 deficiency or inhibition, which improve metabolic syndrome and attenuate atherosclerosis in vulnerable rodent strains, is a target for drug development. However, 11β-HSD1 also converts 7-ketocholesterol (7KC) (which accumulates in fatty tissues), to the potentially more atherogenic, 7β-hydroxycholesterol. Whether a...

ea0025oc1.6 | Young Endocrinologists prize session | SFEBES2011

Evidence for the existence and significance of an alternative pathway towards androgen synthesis during early human life

Reisch Nicole , Dhir Vivek , Berry Andrew , Taylor Angela , Krone Nils , Nogueira Edson , Shackleton Cedric , Hanley Neil , Arlt Wiebke

Congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency (ORD) results in disordered sex development (DSD) in individuals of both sexes. POR provides electrons to CYP17A1 thereby facilitating synthesis of the major androgen precursor dehydroepiandrosterone (DHEA). ORD disrupts this enzymatic step, resulting in deficient synthesis of 5α-dihydrotestosterone (DHT) via DHEA, readily explaining undervirilisation (46,XY DSD) in male ORD neonates. Female virili...

ea0025oc1.7 | Young Endocrinologists prize session | SFEBES2011

Mutant cytochrome b5 causing 46,XY disorder of sex development (DSD) due to apparent CYP17A1 17,20 lyase deficiency

Idkowiak Jan , Randell Tabitha , Dhir Vivek , Patel Pushpa , Shackleton Cedric H L , Krone Nils , Arlt Wiebke

In humans, androgen synthesis crucially depends on the enzyme CYP17A1 expressed in adrenals and gonads. The 17,20 lyase activity of CYP17A1 catalyses the key step in human androgen biosynthesis, the conversion of 17-hydroxypregnenolone to the universal sex steroid precursor dehydroepiandrosterone (DHEA). For its catalytic activity, CYP17A1 requires electron transfer from P450 oxidoreductase (POR). Mutations in CYP17A1 and POR are known to disrupt human androgen s...

ea0025oc1.8 | Young Endocrinologists prize session | SFEBES2011

TSH levels and thyroid hormone prescribing in primary care in the UK

Iqbal Ahmed , Taylor Peter , Panicker Vijay , Sayers Adrian , Greenwood Rosemary , Mukhtar Rasha , Evans Jonathan , Dayan Colin

Objective: Hypothyroidism is common and predominantly managed in primary care. Symptoms are non-specific, with thyroid function tests (TFT) required for diagnosis. We sought to investigate current practice in levothyroxine prescribing in primary care.Methods: We studied the initiation of levothyroxine using the General Practice Research Database (GPRD), the world’s largest database of anonymised medical records. Individuals with i) thyroid cancer ii...