Diabetes, metabolism and cardiovascular

Background: We sought to document the pattern of distribution of cytokines in patients with type 2 DM and compare cytokine levels between DM subjects with and without the Mets.Methods: Out of 200 patients with type 2 DM and 100 healthy sex and aged matched controls were studied. Anthropometric indices, lipid parameters and cytokines levels which included interleukin 10 (IL10), tumor necrosis factor α (TNF), interferon γ (IFN) and C reactive pro...

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ea0025p121 | Diabetes, metabolism and cardiovascular | SFEBES2011

Renal ischemia/reperfusion injury in type II DM: possible role of proinflammatory cytokines, apoptosis, and nitric oxide

Gabr Mahmoud , Hussein Abdel-aziz , Sherif Iman , Ali Sousou , Mohamed Hoda

Background: Diabetes mellitus (DM) especially type II is a major health problem and diabetic nephropathy is the main cause of end stage renal disease (ESRD). Renal ischemia/reperfusion (I/R) injury is common in diabetic patients. Recent studies reported increased vulnerability of kidney to I/R injury in diabetic rats. Mechanisms behind this increased vulnerability not fully understood. The present study investigated the effect of acute ischemia for 45 min on proinflammatory cy...

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ea0025p122 | Diabetes, metabolism and cardiovascular | SFEBES2011

Adult patients with congenital adrenal hyperplasia have elevated blood pressure but otherwise a normal cardiovascular risk profile

Mooij Christiaan , Kroese Jeanne Margot , Sweep Fred , Hermus Ad , Tack Cees

Objective: Treatment with glucocorticoids and mineralocorticoids has changed congenital adrenal hyperplasia (CAH) from a fatal to a chronic lifelong disease. As a result of long-term treatment, including chronic (over-)treatment with glucocorticoids, patients with CAH may develop an adverse cardiovascular risk profile. The objective of this study was to evaluate the cardiovascular risk profile of adult CAH patients.Patients and measurements: In this case...

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ea0025p123 | Diabetes, metabolism and cardiovascular | SFEBES2011

The effects of Syzygium aromaticum derived oleanolic acid on glycogenic enzymes in streptozotocin induced-diabetic rats

Ngubane Phikelelani , Masola Bubuya , Musabayane Cephas

Diabetes mellitus is characterized by partial or total deficiency of insulin resulting in derangement of carbohydrate metabolism and a decrease in the activity of glycogenic enzymes resulting in depletion of liver and muscle glycogen. Accordingly, this study assessed the influence of OA on two key glycogenic enzymes of skeletal muscle and liver tissues in STZ-induced diabetic rats. We have, however, reported that the anti-hyperglycaemic effects of Syzygium aromaticum de...

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ea0025p124 | Diabetes, metabolism and cardiovascular | SFEBES2011

Serum 25-hydroxy-vitamin D is associated with adiponectin and insulin resistance in diabetic Saudi adults

Al-Daghri Nasser , Al-Attas Omar , Alokail Majed , Alkharfy Khalid , Draz Hossam , Clerici Mario

Hypovitaminosis D is associated with an increased prevalence of diabetes mellitus type 2 (DMT2) and the metabolic syndrome. The purpose of this study was to examine the association between 25-hydroxy-vitamin D (25-OH-VitD) levels and adipocytokines and other indices of insulin resistance in a Saudi population with DMT2. One-hundred and fifty-five male and female Saudi adults aged 2680 were randomly selected from the existing Biomarkers Screening in Riyadh Program (RIYADH...

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ea0025p125 | Diabetes, metabolism and cardiovascular | SFEBES2011

Endoplasmic reticulum oxidoreductases and insulin folding

Rajpal Gautam , Liu Ming , Arvan Peter

Proinsulin makes three evolutionarily-conserved disulfide bonds, two of which connect the insulin B and A chains, and one intrachain bond within the A chain. In Type II diabetes mellitus, increasing evidence suggests that insulin-secreting pancreatic β cells show signs of endoplasmic reticulum (ER) stress and an increase in the presence of proinsulin with mispaired disulfide bonds. In addition, heterozygous expression of misfolded mutant proinsulin is known to cause autos...

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ea0025p126 | Diabetes, metabolism and cardiovascular | SFEBES2011

Does the effect of non-alcoholic fatty liver disease confer increased cardiovascular risk in patients with polycystic ovary syndrome?

Dawson Alison , Sathyapalan Thozhukat , Kilpatrick Eric , Atkin Stephen

Background: Polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD) are both associated with the metabolic syndrome and are each associated with increased cardiovascular risk. Endothelial function, an early feature in the development of atherosclerosis, has been shown to be abnormal in both PCOS and NAFLD.The aim of this study was to determine if NAFLD conferred additional cardiovascular risk compared to PCOS alone.<p class="ab...

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ea0025p127 | Diabetes, metabolism and cardiovascular | SFEBES2011

Utility of glycated haemoglobin in diagnosing prediabetes in Asian Indians- A Community Survey: Chandigarh Urban Diabetes Study (CUDS) group

Padala Ravikumar , Bhansali Anil , Walia Rama , Ravikiran M , Sunder G , Bhansali Shobhit , Bhadada Sanjay , Dutta Pinaki

Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63...

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ea0025p128 | Diabetes, metabolism and cardiovascular | SFEBES2011

Safety profile of Vildagliptin in clinical practice: 2-year data from 2 Tertiary hospitals

Siddiqui Mohammad , Gupta Mukul , Wangnoo Subhash , Ahmad Jamal

Background and aims: Proper assessment of long-term safety of newer antidiabetic agents (ADAs) is of prime importance as diabetes is a chronic disease requiring life-long management. The purpose of this analysis was to assess the safety of vildagliptin as monotherapy or as an add-on therapy to already existing ADAs (vildagliptin group) compared to non-vildagliptin group.Materials and methods: Nine hundred and eighty-three patients in vildagliptin group a...

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ea0025p129 | Diabetes, metabolism and cardiovascular | SFEBES2011

Sound mind, but sweet blood: olanzapine induced hyperglycaemia

Mlawa Gideon , Seth Rakhi , Deshmukh Sandeep , Sharp Patrick

Background: Atypical antipsychotic agents are useful in treating patients with schizophrenia and other psychoses, but may cause hyperglycaemia. Hyperglycaemia is not dose dependent and is reversible on stopping the treatment.Occurrence of diabetes after atypical antipsychotic drug administration is of major concern as patients may not recognise their symptoms, and health workers may fail to reach an early diagnosis, with major implications for morbidity ...

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ea0025p130 | Diabetes, metabolism and cardiovascular | SFEBES2011

Cabergoline prevents weight gain in patients evaluated for hyperprolactinaemia

Whyte Martin , Aziz Riaz , Pramodh Sesha , Aylwin Simon

Introduction: Food reward stimuli elevate dopamine levels in brain reward circuits. Decreased dopaminergic signalling may be involved in pathophysiological processes leading to obesity and D2 receptor antagonists (antipsychotics) are associated with a higher risk of obesity. One study has demonstrated an association between the use of a dopamine D2 agonist (bromocriptine) and weight-loss in patients with prolactinoma. We have investigated the effect of cabergoline on body weig...

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ea0025p131 | Diabetes, metabolism and cardiovascular | SFEBES2011

Interactions between glucagon and GLP-1 in neuronal pathways affecting food intake

Parker Jennifer , Simpson Katherine , Minnion James , Field Ben , Ghatei Mohammad , Bloom Steve

Glucagon is released from α-cells in the pancreatic islets and is best known for its role in glucose homeostasis. Glucagon/GLP-1 receptor co-agonists have recently been shown to improve glucose homeostasis and reduce body weight in diet-induced obese mice. Glucagon receptor agonism increases energy expenditure while the GLP-1 receptor agonism prevents glucagon-induced hyperglycemia. Peripherally administered glucagon is also capable of reducing food intake, and glucagon n...

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ea0025p132 | Diabetes, metabolism and cardiovascular | SFEBES2011

The effect of environmental enrichment on food intake, body weight and the HPA axis in laboratory rats

Beale Kylie , Harrison Eleanor , Smith Kirsty , Kerton Angela , Ghatei Mohammad , Bloom Steve , Murphy Kevin

Laboratory rats are commonly used to study energy homeostasis. To accurately record food intake or energy expenditure it is necessary to house rats individually, which can be stressful for social animals. Environmental enrichment may reduce stress and improve welfare in laboratory rodents. However, the effect of environmental enrichment on food intake and thus experimental outcome in rats is unknown. We aimed to determine the effect of environmental enrichment on food intake, ...

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ea0025p133 | Diabetes, metabolism and cardiovascular | SFEBES2011

Plasma Annexin A1 (AnxA1) is inversely correlated with waist to hip ratio in healthy males

Kosicka-Knox Anna , Cunliffe Adam , Mackenzie Richard , Flower Rod , Renshaw Derek

The escalating public health problem represented by obesity has spurred multidisciplinary research into adipose tissue and importantly, the molecular biology of the adipocyte. Recent studies suggest that obesity related metabolic disorders are characterised by chronic mild inflammation as a result of adipocytokine production from fat tissue leading to dysregulation in the pro/anti-inflammatory systemic balance. Adipokines and pro-inflammatory markers are implicated in insulin ...

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ea0025p134 | Diabetes, metabolism and cardiovascular | SFEBES2011

Abstract withdrawn....

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ea0025p135 | Diabetes, metabolism and cardiovascular | SFEBES2011

Characterisation of IGFBP1 molecular forms in healthy persons and patients with diabetes mellitus type 2 or hypoglycemia

Lagundzin Dragana , Nedic Olgica

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are involved in the regulation of glucose metabolism and metabolic disorders. IGFBP1 is the only IGF-binding protein that shows diurnal variation and is inversely correlated to the insulin level. IGFBP1 exists as non-phosphorylated protein and several phosphoforms. Phosphorylation affects the affinity of IGFBP1 for IGFs and, therefore, the ability to regulate IGF action. In the circulation IGFBP1 is associa...

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ea0025p136 | Diabetes, metabolism and cardiovascular | SFEBES2011

The Megalin-Cubilin receptor-mediated endocytic pathway is impaired in Dent's disease renal proximal tubule cell-lines

Gorvin Caroline , Wilmer Martijn , Loh Nellie , Piret Sian , Harding Brian , van den Heuvel Lambertus , Levtchenko Elena , Thakker Rajesh

Receptor-mediated endocytosis (RME), involving megalin and cubilin, mediates renal proximal-tubular reabsorption of glucose, proteins and hormones including insulin, parathyroid-hormone and vitamin D. RME disruption occurs in Dents disease patients with mutations of the chloride/proton antiporter, CLC-5, who suffer from low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis and renal failure. To further investigate the RME role of CLC-5 we established conditio...

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ea0025p137 | Diabetes, metabolism and cardiovascular | SFEBES2011

Influence of metabolic decompensation in children with diabetes mellitus type 1 on changes of QT interval

Meraai Galina , Solntseva Angelika

The basic manifestations of dystrophic changes in heart of children suffering form diabetes mellitus type 1 (DM1) are disturbances of repolarization and depolarization processes, including QT and QTc intervals prolongation. Research objective: to evaluate indices of QT and QTc in children with DM1, to reveal interrelation of the observed changes with the duration of disease, age, sex, levels of cholesterol (CH) and glycemie, BMI, blood pressure, pulse rate.<p class="abstex...

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ea0025p138 | Diabetes, metabolism and cardiovascular | SFEBES2011

Hypogonadism with subsequent multi-organ involvement: a mystery solved

Mohandas Cynthia , Barnes Dennis , Harrington Derek , Haq Masud

A 53-year-old gentleman was seen following a recent diagnosis of type 2 diabetes in May 2009. He had suffered a subarachnoid haemorrhage in 1993 and remained under the local tertiary centre after developing secondary hypogonadism treated with testosterone replacement. The cause had never been established.The patient had previously been diagnosed with seronegative HLA B27 arthropathy and in December 2008 was admitted with acute cardiac failure and atrial ...

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ea0025p139 | Diabetes, metabolism and cardiovascular | SFEBES2011

Pomegranate juice consumption influences urinary glucocorticoids, attenuates blood pressure and exercise-induced oxidative stress in healthy volunteers

Tsang Catherine , Wood Gillian , Al-Dujaili Emad

Background and aim: Antioxidants have been postulated to exert beneficial effects on cardiovascular and neurodegenerative diseases by neutralizing reactive oxygen species (ROS). Exercise and metabolic processes are known to produce ROS. Pomegranates are rich in polyphenolic antioxidants. The aim of this study is to investigate the effects of pomegranate pure juice consumption on blood pressure, lipid peroxidation and urinary glucocorticoid levels before and after a moderate ex...

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ea0025p140 | Diabetes, metabolism and cardiovascular | SFEBES2011

Insulin sensitivity and cytokine response to different exercise modalities in hypoxia in type 2 diabetics

Mackenzie Richard , Maxwell Neil , Elliott Bradley , Brickley Gary , Watt Peter

Continuous aerobic exercise improves glucose tolerance in type 2 diabetics (T2D), with greater improvements during exercise in hypoxia. Continuous exercise has been linked with poor adherence. Positive effects with intermittent exercise (IE) with reduced time commitments would have clear benefits. Exercise and hypoxia both increase pro-inflammatory cytokines, potentially reducing benefits of hypoxia. This study aimed to establish the effects of IE under hypoxic conditions in T...

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ea0025p141 | Diabetes, metabolism and cardiovascular | SFEBES2011

Audit of short synacthen tests in patients with type 2 diabetes mellitus

Manikam Logan , Othonos Nadia , Buch Harit , Gama Rousseau

Background and objective: Addisons disease occurs more frequently in patients with type 1 diabetes mellitus (T1DM) as part of the autoimmune polyendocrine syndromes. There is, however, no such association between adrenal failure and type 2 diabetes mellitus (T2DM). We, therefore, retrospectively audited referrals for short synacthen tests (SST) on patients with T2DM.Methodology: Seven years retrospective study of indications for and results of SST ...

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ea0025p142 | Diabetes, metabolism and cardiovascular | SFEBES2011

Retinal screening in pregnant women with diabetes: ‘are we doing enough'

Mlawa Gideon , Holt Richard , Coleman Mathew , Rennie Christina , Smith Roger

Introduction: NICE recommends that pregnant women with pre-existing diabetes should be offered retinal assessment in the 1st and 3rd trimester by digital retinal imaging. Where retinopathy is already present, an additional assessment should be made in the 2nd trimester.Objectives: To assess the feasibility of retinal screening in pregnancy by a community based mobile retinal screening programme (MRSP).Methods: A retrospective audit...

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ea0025p143 | Diabetes, metabolism and cardiovascular | SFEBES2011

Insulin-mediated pseudoacromegaly

Sam Amir , Tan Tricia , Meeran Karim

Patients with acromegaly have characteristic clinical features of soft tissue overgrowth. Both somatic and metabolic features of acromegaly are secondary to excess GH secretion and high circulating levels of insulin-like growth factor 1 (IGF1). However, an acromegaloid phenotype associated with severe insulin resistance is occasionally seen in the absence of biochemical hallmarks of acromegaly (insulin-mediated pseudoacromegaly). Here we present a case of insulin-mediate...

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ea0025p144 | Diabetes, metabolism and cardiovascular | SFEBES2011

Brain natriuretic peptide rises with exercise at high altitude and is associated with acute mountain sickness scores

Woods David , Hooper Tim , Hodkinson Pete , Ball Steve , Wakeford Rob , Peaston Bob , Bairsto Claire , Green Nic , Mellor Adrian

Acute mountain sickness (AMS) is common at high altitude (HA) and is associated with a relative failure of the natriuresis and diuresis that occurs at HA. The role of brain natriuretic peptide (BNP) in this context has not been thoroughly investigated. We aimed to clarify if BNP rises in response to exercise at HA and if so whether this is related to markers of acclimatization. Thirty-two healthy subjects had assessments of BNP, aldosterone and markers of HA acclimatization (a...

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ea0025p145 | Diabetes, metabolism and cardiovascular | SFEBES2011

Diet-induced obesity with metabolic dysfunction does not alter vascular function or remodelling in young C57Bl/6 mice

Dakin Rachel , Drake Amanda , Walker Brian , Seckl Jonathan , Hadoke Patrick

Obesity is associated with metabolic and vascular dysfunction. Many models have shown insulin resistance reduces endothelium-dependent vasodilation but this is also seen in obese subjects with normal glucose tolerance. There is also evidence of increased response to vascular injury in obese animals, although the mechanisms underpinning this are not fully understood. This study used a mouse model of diet-induced obesity (DIO) to address the hypothesis that obesity causes metabo...

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ea0025p146 | Diabetes, metabolism and cardiovascular | SFEBES2011

Postprandial hypertriglyceridaemia in patients with polycystic ovary syndrome

Aye Myint M , Afolabi Paul R , Sathyapalan T , Wakil Ammar , Wootton S A , Sandeman Derek D , Kilpatrick Eric S , Atkin Stephen L

Background: Postprandial hypertriglyceridaemia is an independent risk factor for cardiovascular diseases. An acute rise of insulin in the fed state suppresses hormone-sensitive lipase to inhibit free fatty acids (FFAs) mobilisation from adipose tissue, and up-regulates lipoprotein lipase to increase FFAs influx to adipose tissue from chylomicrons, that is blunted in insulin resistant states. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and cardiovascu...

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ea0025p147 | Diabetes, metabolism and cardiovascular | SFEBES2011

Abstract withdrawn....

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ea0025p148 | Diabetes, metabolism and cardiovascular | SFEBES2011

Continuous feeding in rats: a novel paradigm for inducing hypocaloric obesity?

Arms-Williams Bradley , Wells Timothy

Patterns of food consumption have a profound influence on hormone rhythmicity and fat storage, but until now only crude manipulations of food availability have been possible in rodents. We have used a CLAMS-based system in conjunction with automated serial blood sampling to investigate the effect of continuous feeding on ghrelin secretion and adiposity. Six-week old male SpragueDawley rats (n=6) were housed in metabolic cages and ad-libitum fed with standar...

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ea0025p149 | Diabetes, metabolism and cardiovascular | SFEBES2011

Improvement of cardiovascular risk factors 12 months after Roux-en-Y surgery

Dawson Alison , Sathyapalan Thozhukat , Sedman Peter , Kilpatrick Eric , Atkin Stephen

Background: Obesity is associated with increased insulin resistance, type 2 diabetes and increased cardiovascular risk leading to atherosclerosis. Bariatric surgery has been shown to improve some of these factors in obese patients with glucose intolerance. A form of bariatric surgery is the Roux-en-Y procedure which can result in greater weight loss and restriction with less malabsorption than other procedures (such as the bilious-pancreatic diversion); but the effect of some ...

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ea0025p150 | Diabetes, metabolism and cardiovascular | SFEBES2011

The prevalence of non alcoholic fatty liver disease in GH deficiency and the effect of GH replacement

Gardner Chris , Irwin Andrew , Joseph Francis , Wong Chris , Adams Val , Daousi Christina , Kemp Graham , Cuthbertson Daniel

Background: Non-alcoholic fatty liver disease (NAFLD) is reported to be more prevalent in patients with GH deficiency (GHD) than in the general population. Case control studies have not however been undertaken. Recognition of NAFLD is important due to its association with cardiovascular disease and chronic liver disease.Aims: To determine i) the prevalence of NAFLD in patients with severe GHD compared to age and BMI-matched controls, and, ii) the effect ...

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ea0025p151 | Diabetes, metabolism and cardiovascular | SFEBES2011

Serum erythropoietin levels in patients with acute myocardial infarction

Islam Elham , Zaki Iman , Abdelsalam Mona , Abdelsalam Ahmed , Eltohamy Samya , Morsi Ahmed

Background: Mortality and morbidity after acute myocardial infarction (AMI) remain high even when myocardial reperfusion is successful. Thus, additional approaches are warranted. Erythropoietin (EPO) was found to be a cytoprotective molecule that might represent a novel strategy to limit the infarct size.Aim of the work: To investigate serum erythropoietin level and its relation to infarct size in Egyptian patients with AMI.Methods...

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ea0025p152 | Diabetes, metabolism and cardiovascular | SFEBES2011

Low testosterone and severity of erectile dysfunction (ED) are independently associated with poor health related quality of life (HRQoL) in men with type 2 diabetes

Brooke Jonathan , Walter Debbie , Muraleedharan Vakkat , Marsh Hazel , Kapoor Dheeraj , Jones T Hugh

Introduction: Both low testosterone levels and erectile dysfunction (ED) are highly prevalent in men with type 2 diabetes. Lower testosterone levels are known to be associated with worsening severity of ED as assessed using the International Index of Erectile Function score (IIEF). Testosterone deficiency and erectile dysfunction are both independently correlated with increased risk of cardiovascular disease.Aim: To investigate the effect of low testoste...

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ea0025p153 | Diabetes, metabolism and cardiovascular | SFEBES2011

Glucagon like peptide-1 in congestive heart failure cases and type 2 diabetes mellitus cases

Sheriba Nrmin , Khaled Makboul , Abdelsalam Mona , Mohamed Hisham , Hamam Ahmed

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of beta cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 dia...

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ea0025p154 | Diabetes, metabolism and cardiovascular | SFEBES2011

Over-expression of iodothyronine deiodinase III in the hypothalamic VMN as a potential model of local hypothyroidism

Greenwood Hannah , Counsell John , Richardson Errol , Dhillo Waljit , Boelen Anita , Williams Graham , Bassett Duncan , Bloom Steve , Gardiner James

The hypothalamo-pituitarythyroid (HPT) axis maintains controlled systemic levels of thyroid hormone (TH). This is achieved through negative feedback via the hypothalamic arcuate and paraventricular nuclei. The effects of thyroid hormone in other hypothalamic nuclei are yet to be elucidated. Administration of triiodothyronine (T3, thyroid hormone) into the hypothalamic ventromedial nucleus (VMN) increases food intake in rats. Thyroid hormone activation and inac...

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ea0025p155 | Diabetes, metabolism and cardiovascular | SFEBES2011

The effect of glucose on hypothalamic neuropeptide Y release investigated using static incubation of hypothalamic explants

Hussain Syed Sufyan , Richardson Errol , Buckley Niki , Bewick Gavin , Bloom Stephen , Gardiner James

Attenuated glucoprivic feeding responses are a feature of hypoglycaemic unawareness in insulin-treated diabetes. Glucose alters the activity of hypothalamic neurones involved in regulating appetite. Arcuate nucleus (ARC) Neuropeptide Y (NPY) releasing neurones stimulate feeding. The identification of glucose-sensitive NPY releasing hypothalamic neurones suggests a strong role for these neurones in mediating changes in appetite induced by alterations of glucose. To gain a bette...

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ea0025p156 | Diabetes, metabolism and cardiovascular | SFEBES2011

Attenuated atherosclerosis in 11β-hydroxysteroid dehydrogenase type 1 deficient ApoE^−/− mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat

Kipari Tiina , Man Tak-Yung , Hadoke Patrick , Savill John , Chapman Karen , Seckl Jonathan

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates glucocorticoids in intact cells, converting inert cortisone into active cortisol. We have previously shown attenuated atherosclerosis development, reduced plasma monocyte chemoattractant protein-1 (MCP-1) and reduced macrophage/T cell infiltration within atherosclerotic lesions in 11β-HSD1−/−×ApoE−/− double knock-out (DKO) mice fed western diet (WD)....

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ea0025p157 | Diabetes, metabolism and cardiovascular | SFEBES2011

Study of serum prolactin and cardiovascular risk in patients with type 2 diabetes mellitus

Elgayar Hisham , Abu-Shady Manal , Zaki Iman , Abdelsalam Mona , Elsherbeny Alyaa

Background: Prolactin is an identified marker associated with atherosclerosis. Atherosclerotic process and hence the macrovascular complications are causes for high mortality and morbidity rates among people with diabetes.Aim: To assess the relationship between serum prolactin and cardiovascular risk in patients with AMI and patients with type 2 diabetes mellitus.Subjects and methods: A casecontrol study was done in Ain Shams...

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ea0025p158 | Diabetes, metabolism and cardiovascular | SFEBES2011

Effect of diet/lifestyle advice on weight change in an unselected polycystic ovary syndrome (PCOS) population

Sinha Khushboo , Albeyatti Abdullah , White Davinia , Franks Stephen , Webber Lisa

Objectives: To examine the effect on weight change of diet/lifestyle advice to maintain/achieve a healthy weight in an unselected PCOS population.Methods: All overweight patients attending the Reproductive Endocrine clinic with PCOS are routinely given lifestyle advice for weight loss by their consultant, offered referral to see a dietician and, when clinically appropriate, prescribed orlistat. Clinical notes were reviewed for 50 consecutive patients wit...

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ea0025p159 | Diabetes, metabolism and cardiovascular | SFEBES2011

Investigating the effects of testosterone on inflammatory markers of early aortic atherosclerosis in the testicular feminised mouse (Tfm) model

Kelly Daniel , Sellers Donna , Woodroofe Nicola , Jones Hugh , Channer Kevin

Objectives: The over-recruitment and activation of leukocytes characteristic of early atherosclerosis is considered the driving force behind atheroma development and is regulated by the concerted activities of several cytokines, chemokines and adhesion molecules surrounding a lipid core. Low serum testosterone levels are associated with cardiovascular disease in men and clinical trials demonstrate that testosterone replacement therapy (TRT) improves symptoms and reduces the in...

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ea0025p160 | Diabetes, metabolism and cardiovascular | SFEBES2011

Study of the adipocytokine visfatin in obesity and type 2 diabetes mellitus

Shelbaya Salah , Shoeib Nehad , Seddik Salwa , Makboul Khalid , Abd El Baki Rania , Fahmy Eman , El-ghohary Eman

Background: Visceral fat-derived protein named visfatin was discovered in 2005. Visfatin may improve glucose tolerance, and its plasma levels correlate strongly with the amount of visceral adipose tissue in humans. Visfatin has insulin-like metabolic effects on glucose metabolism but has a distinct binding site on insulin receptors. These findings triggered great interest for many researchers to explore the mechanism(s) of regulation of visfatin expression, and the possible re...

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ea0025p161 | Diabetes, metabolism and cardiovascular | SFEBES2011

Study of lipoprotein phospholipase A₂ as a biomarker for cardiovascular events in type 2 diabetes mellitus

El-Gayar Mohamed , Sabry Inas , Abd El Baki Rania , Abass Magdy , Attia Abd-El-Azeem

Background: Type 2 diabetes (T2DM) represents an independent risk factor for cardiovascular diseases (CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Lipoprotein-associated phospholipase A2 (Lp-PLA2) may have a pro-inflammatory role as growing evidence suggests that it acts in several pathways that contribute to atherogenesis.Objective: The objective is to study Lp-PLA2 a...

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ea0025p162 | Diabetes, metabolism and cardiovascular | SFEBES2011

Serum 25-hydroxyvitamin D₃ concentrations and cardiovascular risk among type 2 diabetic patients

Shelbaya Salah , Sedeek Salwa , Abd El Baki Rania , Ibrahim Nesma

Background: There is accumulating evidence suggesting that altered vitamin D may play a role in the development of T2DM. A growing body of evidence suggests that low levels of vitamin D may adversely affect the cardiovascular system.Objective: This is to assess the relation of serum 25 OH vitamin D concentrations and risk of CVD in T2DM patients.Subjects and methods: Seventy subjects aged from 40 to 60 years were chosen excluding t...

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ea0025p163 | Diabetes, metabolism and cardiovascular | SFEBES2011

Low testosterone predicts increased mortality and testosterone replacement therapy improves survival in men with type 2 diabetes

Muraleedharan Vakkat , Marsh Hazel , Jones Hugh

Background: Low testosterone in men is associated with increase in all-cause and cardiovascular mortality. There is a high prevalence of hypogonadism in men with type 2 diabetes and testosterone replacement therapy (TRT) improves cardiovascular risk. However there is no published data regarding mortality in these patients in relation to testosterone levels, and the long term effect of TRT on mortality.Aim: We report a 6 year follow-up study examining the...

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ea0025p164 | Diabetes, metabolism and cardiovascular | SFEBES2011

Chronic GH excess is associated with adenosine monophosphate-activated protein kinase (AMPK) threonine-172 phosphorylation changes that do not lead to changes in AMPK activity

Thomas Julia , List Edward , Kopchick John , Grossman Ashley , Korbonits Marta

GH influences multiple metabolic pathways. Excess GH (acromegaly) causes a distinct form of cardiomyopathy, which may progress to fulminant heart failure. AMPK is an energy conservation enzyme that modulates multiple areas of the cell stress response, inhibiting anabolism and promoting catabolism. AMPK is activated by phosphorylation at Thr172 and measurement of Thr172 phosphorylation is thought to correlate with enzyme activity. We investigated the influence of GH on cardiac ...

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ea0025p165 | Diabetes, metabolism and cardiovascular | SFEBES2011

Differential effects of olanzapine and risperidone on plasma adiponectin levels over time: results from a 3-month prospective open-label study

Heald Adrian , Hanssens Linda , van Winkel Ruud , Collette Julien , Peuskens Joseph , Reginster Jean Yves , Scheen Andre , Wampers Martien , de Hert Marc

Aims: Second-generation antipsychotics (SGA), especially clozapine and olanzapine, are associated with increased metabolic risk. Plasma adiponectin levels, vary in schizophrenia patients as in the general population according to gender, adiposity and metabolic syndrome (MetS).Here, we investigated whether different SGAs differentially influence plasma adiponectin levels independent of body mass index (BMI) and MetS status.Methods: ...

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ea0025p166 | Diabetes, metabolism and cardiovascular | SFEBES2011

Lack of beneficial metabolic profile in liver-specific 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) knockout mice

Lavery Gareth , Rabbitt Elizabeth , Zielinszka Agnieszka , Huges Beverley , Semjonous Nina , Saqib Khalid , Morgan Stuart , Gathercole Laura , Walker Elizabeth , Stewart Paul

In humans glucocorticoid (GC) excess can promote hepatic glucose and triglyceride production contributing to obesity, fatty liver and diabetes. 11β-HSD1 activates GCs (11-DHC to corticosterone in mice), thereby increasing tissue concentrations. The liver has the highest 11β-HSD1 activity, and its inhibition has emerged as a therapeutic option. To investigate this we generated 11β-HSD1 liver-specific knockouts (HSD1LKO) and examined GC metabolism and responses to...

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ea0025p167 | Diabetes, metabolism and cardiovascular | SFEBES2011

Defining multipotent progenitors in the human fetal pancreas by expression and ChIP-seq

Jennings Rachel , Berry Andrew , Rodriguez Santiago , Pasquali Lorenzo , Moran Ignasi , Roberts Neil , Hanley Karen Piper , Ferrer Jorge , Hanley Neil

Understanding how fate choices are made by multipotent progenitors during pancreas development is valuable information in the quest for regenerative medicine and cell therapy to treat diabetes mellitus. Pancreatic differentiation is well defined and understood in rodents however, human data are comparably scarce. Specifically, when human pancreatic progenitors are multipotent is unknown as are the epigenetic changes that these cells undergo during their differentiation to beta...

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Society for Endocrinology BES 2011

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