The manifestation of adrenal disorders during pregnancy is a rare but regularly occurring event and can pose significant problems for the involved medical professionals. This lecture will give an overview of the major management issues surrounding disorders of the adrenal cortex during pregnancy. This includes the requirements for the adjustment of corticosteroid replacement therapy in adrenal insufficiency, due to the physiological changes in corticosteroid secretion during pregnancy and subsequent to the anti-mineralocorticoid action of progesterone. The lecture will include brief remarks on the management of the pregnant patient with congenital adrenal hyperplasia. Cushing syndrome can present during pregnancy and the lecture will highlight the diagnostic and therapeutic problems associated with this, including the choice and timing of medical and surgical interventions. Finally, major issues associated with the management of adrenal masses during pregnancy will be discussed.