Adiponectin (ADPN), resistin (RSN) and leptin are proteins that affect insulin resistance and atherosclerosis significantly. Although low levels of adiponectin and high levels of resistin and leptin are associated with coronary heart disease and cardiovascular disease risk factors, it is unclear whether adiponectin, resistin and leptin levels are related to the risk of developing ischemic stroke. The aim of the study was to evaluate the adiponectin, resistin and leptin serum levels in patients with acute ischemic stroke and theirs role in the pathogenesis of cerebrovascular diseases. We examined 70 patients with acute ischemic stroke and 30 stroke-free subjects of similar age and sex distribution. In all subjects we examined lipid pattern (cholesterol, HDL-cholesterol, LDL-cholesterol, triglicerydes), blood glucose level, blood pressure, BMI and HOMA-IR.
Results: In comparison with referents, patients with stroke had significantly higher leptin (14.98 vs 10.47 ng/ml) and resistin (28.92 vs 12.25 ng/ml) levels, but adiponectin (15.49 vs 14.32 μg/ml) did not differ between groups.
Conclusions: Despite moderate associations between adiponectin and cardiovascular disease risk factors, we found no evidence of an association between serum adiponectin levels and incident ischemic stroke. Leptin and resistin may are an important links to the development of cerebrovascular disease.