Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 25 P2


Influence of age and gender on expression of primary hyperparathyroidism

Viral Shah, Sanjay Bhadada, Anil Bhansali, Pinaki Dutta & A Behara


Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: The geographical difference in presentation of primary hyperparathyroidism (PHPT) is well known however, there is spare literature on influence of age and gender on presentation of PHPT.

Objective: To study the effect of age and gender on clinical and biochemical presentation of PHPT.

Method: This is a retrospective analysis of 184 histopathologically proven PHPT patients between March 1990 and March 2010 from a single centre of North India. PHPT patients were divided in five different age groups, i.e. children <12 years, adolescent 12–18 years, young adult 19–25 years, adult 26–59 years and older ≥60 years. Clinical presentations, biochemical parameters and parathyroid gland weight were compared among different age groups and between genders.

Results: Female:male ratio was 70:30%. 77.2% were between 25 and 59 years while 5.97% were <12 years. There was no change in clinical presentations and biochemical parameters among the different age groups except rickets in children and adolescent (2.2%), and renal stones in 25–59 years adults (41.3%) and markedly elevated alkaline phosphatase in children and adolescent (P<0.01). Bone pain and muscle aches (P<0.01), fracture (P=0.04), renal stone (P=0.05), cholelithiasis (P=0.03) and pancreatitis (P=0.02) were more common among women. Serum calcium and phosphate levels were similar in either sex but parathyroid hormone (PTH) level was higher among women (P=0.02). Parathyroid adenoma weight was higher in older compare to young but did not reach to level of statistical significance.

Conclusion: There was no much difference in the clinical and biochemical presentation of PHPT among different age groups but differences among genders were noticeable.

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