Endocrine Abstracts

Over the past 10 years, tremendous advances have been made in understanding the role that genetic factors play in the regulation of bone metabolism and bone disease. Most bone diseases have a strong genetic component but for many of these the genetic architecture is incompletely understood. However it is clear that in some diseases, there is Mendelian inheritance of the phenotype due to alleles that have a large effect size, whereas in other diseases, the inheritance is polyge...