Endocrine Abstracts

Allopregnanolone (APα), a neurosteroid, significantly increased proliferation of rodent and human neural progenitor cells in vitro via GABA receptor channel and L-type channel mechanisms that activated the cell cycle. We subsequently investigated the efficacy of APα to promote neurogenesis in the hippocampal subgranular zone (SGZ), to reverse learning and memory deficits in the 3 month-old male triple transgenic mouse model of Alzheimer’s (3xTgAD). AP&#94...