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Endocrine Abstracts

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13th European Congress of Endocrinology

Poster Presentations

Cardiovascular endocrinology and lipid metabolism

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Clinical case reports

ea0026p549 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Hashimoto's disease presenting as cardiac tamponade

Khanal Rashmi , Sharma Tarun , Aziz Fahad

Introduction: Chronic longstanding hypothyroidism is a known cause of pericardial effusion. However, cardiac tamponade as the primary presentation of Hashimoto’s hypothyroidism is relatively uncommon.Case description: A 34-year-old African American woman presented to the ER complaining of shortness of breath, fever, cough and precordial chest pain of 1 day duration. Examination revealed an obese female with patchy alopecia and dry skin in mild respi...
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ea0026p550 | Cardiovascular endocrinology and lipid metabolism | ECE2011

The relation between metabolic syndrome and cognitive decline in elderly Turkish people

Zuhur Sayid Shafi , Karadag Berrin , Altuntas Yuksel

Objective: To determine the relationship between metabolic syndrome (MS) and cognitive decline in people over 60 years age.Methods: The age of the participants were between 60 and 89 years old (71.71±6.58). According to NCEP ATP III criteria 93 had MS and 47 had not. Cognitive performance was determined with the use of standardized mini mental test and the mini mental scores (MMS) of the two groups were compared. Apart from the MS we investigated th...
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ea0026p551 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Relationship between N-terminal pro-B-type natriuretic peptide levels and metabolic syndrome

Bao Yuanyuan , Shang Xiliang , Zhou Linuo , Hu Renming

Instruction: Previous studies have been shown that obese individuals have reduced natriuretic peptide levels. But conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors. We investigated the relationship between plasma N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) and metabolic syndrome (MetS), metabolic risk factors in 469 patients free of heartfailure.Material and methods: Two hundred and thir...
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ea0026p552 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Inflammation indices and insulin resistance in metabolic syndrome with and without coronary artery disease

Khademi Mojtaba , Nikparvar Marzieh , Zare Shahram , Solati Mehrdad

Background: Obesity, particularly abdominal obesity, is associated with resistance to the effects of insulin on peripheral glucose and fatty acid utilization, often leading to type 2 diabetes mellitus. Insulin resistance, the associated hyperinsulinemia and hyperglycemia, and adipocyte cytokines (adipokines) may also lead to vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation, all of which promote the development of atherosclero...
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ea0026p553 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Regulation of fuel metabolism during exercise in hypopituitarism with growth hormone-deficiency (GHD)

Christ E R , Alleman S , Egger A , Stettler C

Introduction: Hypopituitary patients with GHD tend to have a reduced exercise capacity. GH is secreted during exercise, has a strong lipolytic action and has been shown to be positively correlated with exercise performance. We hypothesized that the lack of GH leads to a reduced systemic availability of free fatty acids (FFA) during exercise thereby affecting exercise performance.Methods: Patients with GHD and matched sedentary control subjects (CS) were ...
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ea0026p554 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Prevalence of androgen deficiency in males with metabolic syndrome: relation between hormonal and metabolic parameters

Becerra Antonio , Perez-Lopez Gilberto , Menacho Miriam , Rodriguez-Molina Jose M , Lucio M Jesus , Asenjo Nuria , Villar Rosa

Androgen deficiency in the aging male has become an actual topic due to the aging population and finding from different studies that shown a progressive decline of serum levels of age-related testosterone. These levels have been inversely related with markers of metabolic syndrome and cardiovascular disease.The aim of this observational study was to investigate the relation of endogenous testosterone and other sex hormones with different components of me...
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ea0026p555 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Polycystic ovary syndrome and their relationship with metabolic syndrome in female-to-male transsexuals

Becerra Antonio , Lopez Gilberto Perez , Menacho Miriam , Molina Jose Miguel Rodriguez , Lucio M Jesus , Asenjo Nuria

Objective: To determine the prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism and their relationships with metabolic syndrome (MS) parameters in female-to-male transsexuals (FMT).Design and methods: Seventy-seven FMT were assessed clinically and biochemically to hyperandrogenism, before the beginning of the treatment with testosterone. We also assessed cardiovascular risk factors and other parameters of MS.Results...
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ea0026p556 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Is metabolic syndrome a useless category in subjects with high cardiovascular risk? Results from a cohort study in men with erectile dysfunction

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Although several studies have demonstrated that MetS is associated with a twofold increase in the risk of cardiovascular (CV) diseases, this risk does not appear to be greater than the sum of risks associated with each of its individual components. To determine the association of men with ED and individual components of MetS and their subsequent relationship to cardiovascular (CV) risk, and, more specifically whether the sum of the MetS components is greater than...
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ea0026p557 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Prolactin levels independently predict major cardiovascular events in patients with erectile dysfunction

Corona Giovanni , Rastrelli Giulia , Boddi Valentina , Monami Matteo , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: We previously reported that in subjects consulting for sexual dysfunction lower PRL plasma levels were associated with worse lipid and glycemic profile, as well as with a higher prevalence of metabolic syndrome and arteriogenic erectile dysfunction (ED). To assess possible associations between PRL levels and incident major cardiovascular events (MACE) in subjects with ED.Methods: This is an observational prospective cohort study evaluating ...
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ea0026p558 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction

Corona Giovanni , Rastrelli Giulia , Monami Matteo , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Obesity is an independent cardiovascular (CV) risk factor. Testosterone (T) is inversely related to body mass index (BMI) in males. There is substantial evidence suggesting that low T could play a role as a moderator of CV mortality in men, and so this study is designed to assess the possible interaction between T and obesity in predicting major cardiovascular events (MACE) in a sample of subjects with erectile dysfunction.Methods: This is ...
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ea0026p559 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction

Bandini Elisa , Fisher Alessandra , Corona Giovanni , Ricca Valdo , Monami Matteo , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Erectile dysfunction (ED) and mood depression are often associated and both are correlated with an increased risk of cardiovascular morbidity and mortality. The aim of the present study is to explore biological and clinical correlates of depressive symptomatology in a sample of men consulting for sexual dysfunction and to verify possible associations between depressive symptoms and incidence of major cardiovascular events (MACE).Methods: A ...
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ea0026p560 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Priapus is happier with Venus than with Bacchus

Corona Giovanni , Boddi Valentina , Monami Matteo , Fisher Alessandra , Bandini Elisa , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: The relationship between alcohol consumption and erectile function is still not completely clarified. Aims of the present study are to explore a number of biological and clinical correlates of alcohol consumption in a sample of men consulting for sexual dysfunction, and to verify possible associations with the incidence of major adverse cardiovascular events (MACEs).Methods: A consecutive series of 1956 (mean age 55±11.9 years old) att...
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ea0026p561 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Young women with the polycystic ovary syndrome (PCOS) have evidence of endothelial dysfunction but not of altered arterial structure

Duncea I , Ilie I R , Georgescu C , Marian I , Mocan T , Man B , Brad C , Hazi G

Aim: The aim of our study was to assess the presence of endothelial dysfunction and of increased carotid intimae-media thickness (IMT), two precocious markers of atherosclerosis in PCOS subjects. Simultaneously, their relationship with some metabolic, hormonal and anthropometric parameters was analyzed.Methods: The study group consisted of 45 women with PCOS (age=23.1±4.1 years, body mass index (BMI) =28.4±5.9 kg/m2). Thirty-two heal...
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ea0026p562 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Metabolic syndrome and the effect of testosteron treatment in young men with congenital hypogonadotrophic hypogonadism

Sonmez A , Haymana C , Bolu E , Aydogdu A , Tapan S , Serdar M , Altun B , Barcin C , Taslipinar A , Meric C , Uckaya G , Kutlu M

Objective: The relationship between metabolic syndrome (MS) and hypogonadism has always been investigated in study groups confounded with aging, obesity or chronic metabolic disorders. So far there has been no data about the presence of MS in young hypogonadal patients. Also there is controversial data about the metabolic effects of testosteron replacement therapy. We investigated the frequency of MS in treatment naïve, young men with congenital hypogonadal hypogonadism (...
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ea0026p563 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Determinants and outcome of amiodarone-associated thyroid dysfunction

Ahmed S , Van Gelder I C , Wiesfeld A C P , Van Veldhuisen D J , Links T P

Background: Amiodarone is frequently associated with thyroid dysfunction. Identifying predictors for amiodarone-associated thyroid dysfunction and assessing treatment outcome may aid clinicians in daily practice.Patients and methods: In our retrospective study, we included 303 consecutive patients with amiodarone therapy for cardiac arrhythmias (260 with atrial fibrillation and 43 with ventricular arrhythmias). Thyroid function tests were performed every...
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ea0026p564 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Abstract withdrawn....
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ea0026p565 | Cardiovascular endocrinology and lipid metabolism | ECE2011

C-reactive protein and fibrinogen are strong predictors of the cardiovascular outcome in subjects with subclinical atherosclerosis and the metabolic syndrome

Patti A M , Rizzo M , Corrado E , Coppola G , Muratori I , Novo G , Rini G B , Novo S

Background: The presence of the metabolic syndrome (MS) increases cardiovascular morbidity and mortality but few data is available on the outcome in subjects with the MS and subclinical atherosclerosis.Aim: We aimed to assess cardio- and cerebro-vascular events in subjects with MS and subclinical atherosclerosis.Methods: We followed-up for 5 years 339 subjects with asymptomatic carotid intima-media thickness >0.9 mm, of whom 13...
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ea0026p566 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Apolipoprotein A1 and B100 and hormones in postmenopausal women

Oros S E , Ianas O , Manda D , Rosca R I , Vladoiu N S , Popa O M , Giurcaneanu M , Dumitrache C

Menopause is a physiological condition associated with an important change in the hormonal status, an adverse lipid profile and cardiovascular risk. Apolipoproteins are proteins that bind to lipids to transport them. Apolipoprotein intestine synthesis is regulated principally by the fat content of the diet, while in the liver by dietary composition, hormones, alcohol intake and lipid lowering drugs. Are they changed due to aging? Do they interfere in the hormonal changes?<...
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ea0026p567 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Cortisol secretion and HPA axis activity in patients undergoing coronary angiography

Isailovic T , Petakov M , Macut D J , Antic J , Ognjanovic S , Popovic B , Bozic I , Elezovic V , Bogavac Tamara , Damjanovic Svetozar

Introduction: Several studies have shown that cortisol and altered HPA axis activity may participate in pathogenesis and severity of coronary artery disease (CAD).Aim: To examine possible interaction between cortisol secretion and HPA axis activity with severity of CAD.Patients and methods: Diurnal cortisol secretion and dexamethasone suppression test (DST) were analyzed in 200 consecutive patients (mean age 59.3±8.6) referred...
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ea0026p568 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Plasma levels of the neurohormones A and B-type natriuretic peptides increases after weight loss in severe obesity

Kistorp C , Christensen R , Goetze J P , Bliddal H , Faber J

Introduction: The neurohormones A and B-type natriuretic peptides are markedly increased in patients with heart disease, and are well established as useful diagnostic biomarkers. Obesity is a known risk factor for cardiovascular disease. Cross sectional data suggest however that plasma levels are reduced among obese. Therefore, the aim of the present study was to investigate the impact of weight loss and corresponding changes in body composition on plasma levels of A and B-typ...
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ea0026p569 | Cardiovascular endocrinology and lipid metabolism | ECE2011

α-Defensins are novel biomarkers of low grade inflammation with strong prognostic impact in patients with heart failure

Kistorp C , Christensen H M , Frystyk J , Flyvbjerg A , Hildebrandt P , Schou M , Faber J

Introduction: α-Defensins are recently described peptides, which are part of the innate immune system. Increased circulating levels are observed in conditions associated with chronic low grade inflammation, such as ischemic heart disease and in diabetes mellitus (DM). Recently we reported adverse prognostic implications of high α-defensins in patients with type 1 DM. However, it is not clear whether this finding may be generalized to include other groups such as pati...
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ea0026p570 | Cardiovascular endocrinology and lipid metabolism | ECE2011

B-type natriuretic peptide modulates the response to intravenous glucose in a placebo-controlled cross-over study in healthy volunteers

Heinisch B , Vila G , Resl M , Riedl M , Luger A , Pacini G , Clodi M

B-type natriuretic peptide (BNP) is a hormone secreted from the heart in response to volume load and serves clinically as a reliable biomarker in the diagnosis of cardiac dysfunction and heart failure. As patients with heart failure present an increased risk for developing diabetes, we aimed to investigate the role of BNP on parameters of glucose metabolism in a placebo-controlled crossover study performed in 10 healthy volunteers (25±1 years; BMI 23±1 kg/m2</su...
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ea0026p571 | Cardiovascular endocrinology and lipid metabolism | ECE2011

D-Lys-GHRP-6, an antagonist of ghrelin receptor type 1a, did not antagonize the effect of acylated ghrelin but antagonized the effect of unacylated ghrelin on the growth of HECa10 murine endothelial cell line

Melen-Mucha G , Polowinczak-Przybylek J

Ghrelin is expressed in endothelial cells but its precise role remains unknown. Some authors treat ghrelin as an endogenous regulator of angiogenesis.The aim of this study was to examine the direct effect of human acylated and unacylated ghrelin and rat acylated ghrelin applied alone or together with D-Lys-GHRP-6, an antagonist of ghrelin receptor type 1a, on the growth of murine endothelial cell line HECa10 assessed by Mosmann method i...
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ea0026p572 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Phosphate levels inversely correlate with aortic stiffness in patients with primary hyperparathyroidism

Athanasouli Fanni , Papadopoulos Leonidas , Vemmou Anastasia , Chalaris Konstantine , Efthimiou Evelin , Athanasoulis Theodore , Papamichael Christos , Stamatelopulos Kimon , Terpos Evangelos , Alevizaki Maria

Introduction: Although data on the association of primary hyperparathyroidism (pHPT) with cardiovascular disease are accumulating, there is still controversy on this issue. Moreover, possible associations of aortic stiffness and central aortic pressures with pHPT and associated effective molecules have not been addressed.Methods: Seventy patients with pHPT were consecutively recruited from the outpatients’ clinic of an academic department of endocri...
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ea0026p573 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Low sex hormone binding globulin – strong association with metabolic syndrome in patients with acute coronary syndrome

Payer J P , Banarova A B , Koller T K , Jackuliak P J

Objective: Despite of conflicting data, reduced levels of endogenous sex hormones and especially sex hormone binding globulin (SHBG) seem to be associated with metabolic syndrome (MS). In this study we determined relationship between endogenous sex hormone levels and SHBG and components of metabolic syndrome in both sexes.Methods: In 39 men (median age 70.2) with total testosterone level in the lowest quartile of normal range (median 12.8 nmol/l) and 29 ...
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ea0026p574 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Thyroid and parathyroids' dysfunction in patients suffering from chronic renal failure

Djurica Snezana , Vuksanovic Miljanka , Arsenovic Branka

The aim of this study was to investigate the contribution of thyroid and parathyroid glands dysphunction to the arterial hypertension ethiology in elderly patients suffering from hronic renal failure.In 34 patients, average age of 67 years (range: 65–68), with glomerular filtration rate (GFR, 99mTcDTPA) <60 ml/min, as well as the creatinine clearence (Cockcroft) values between 60 and 30 ml/min, thyroid gland function was analys...
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ea0026p575 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Possible association between polyunsaturated fatty acids and parameters of metabolic syndrome in type 2 diabetes mellitus-pilot study

Rasic-Milutinovic Z , Vujovic M , Popovic-Radinovic V , Tica J , Gluvic Z , Lackovic M , Perunicic-Pekovic G , Popovic T

Bacground: In type 2 diabetes mellitus (T2DM), the level of polyunsaturated fatty acids (PUFA), is usually decreased, and could be accused for metabolic disturbance, chronic inflammation, and accelerated atherosclerosis. The aim of this study was to determine if there is any relationship between composition of plasma phospholipids PUFAs and parameters of metabolic syndrome.Methods: The study was cross-sectional. Fifteen T2DM patients 63.22±7.20, BMI...
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ea0026p576 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Parathormone 1-84 in type 2 diabetic patients

Belovici M I , Buysschaert M

Objective: Increasing evidence suggests a role for mineral metabolism in cardio-vascular disease risk. We aimed at determining in type 2 diabetes patients the relationship between serum levels of 1–84 parathormone (PTH1–84), 25-hydroxy-vitamin D (25(OH)D) or calcium and the glycated hemoglobin (HbA1c), insulin sensitivity or β-cells function, but also the relationship between these factors and coronary arterial disease confirmed by myocardial scintigraphy.<p...
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ea0026p577 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Rhabdomyolysis associated with fenofibrate: a case report

Oz Derya , Hatipoglu Ogun , Alarslan Pinar , Kurt Hafize , Fidan Nuri , Ozmen Bilgin , Hekimsoy Zeliha

Rhabdomyolysis is a characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. Most cases are associated with a predisposing factor such as high dose statin therapy, diabetes, old age, female gender, renal failure or hypothyroidism.An 80-year-old woman presented with severe and generalized muscle pain. Her medical history included hypertension, congestive heart failure, chronic atrial fibrillation and a thy...
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ea0026p578 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Utility of brain natriuretic peptide (BNP) as a biomarker of risk assessment in acute pulmonary embolism

Pascu Alina Mihaela , Radoi Mariana , Bobescu Elena , Stanciu Mihaela , Toma Sebastian Ionut , Burta Olivia Ligia

Introduction: Acute right ventricular dysfunction (RVD) on echocardiography (ECHO) represents the actual gold standard in risk stratification of patients with pulmonary embolism (PE). We previously demonstrated that plasma BNP above a cut-off level of 50 pg/ml could predict acute RVD in PE.Aim and objective: Analysis of the utility and accuracy of plasma BNP in detecting acute RVD in PE.Methods: Seventy patients with confirmed PE, ...
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ea0026p579 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Correlation of atherogenic dyslipidemia with other plaque instability biomarkers and outcome in non ST-segment elevation acute coronary syndromes (NSTE-ACS)

Bobescu Elena , Pascu Alina Mihaela , Radoi Mariana , Datcu Georgeta , Dobreanu Dan , Totoianu Gheorghe Ioan , Stanciu Mihaela , Burta Ovidiu

Introduction: Atheromatous plaque instability biomarkers are the most important predictors for the evolution with major acute cardiovascular events (MACE) in patients with NSTE-ACS.Objective: To evaluate the impact of dyslipidemia, endothelial dysfunction, oxidative stress, platelet hyperactivity and hypercoagulable state and their inter-correlation on the outcome of NSTE-ACS.Methods: Two hundred and forty patients with NSTE-ACS, 1...
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ea0026p580 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography

Tomaschitz A , Pilz S , Ritz E , Grammer T , Amrein K , Boehm B O , Marz W

Introduction: An increasing notion suggests that aldosterone contributes to the development and progression of atherosclerosis and cardiovascular disease. Experimental studies documented an upregulation of cellular adhesion molecules, which are involved in the pathogenesis of atherosclerosis, after administration of aldosterone. However, evidence for an association between circulating aldosterone levels and soluble cellular adhesion molecules in humans is sparse.<p class="...
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ea0026p581 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Long term recreational physical exercise decreases angina susceptibility and induces cardiovascular protective shifts in nitric oxide synthase, heme oxygenase and matrix metalloproteinase enzyme regulation in rats

Szabo R , Posa A , Szalai Z , Szablics P , Varga C S , Berko A M , Orban K , Laszlo F

Introduction: Physical inactivity, i.e. sedentary life style increases circulatory disease risk. Carbon monoxide and nitric oxide produced by the heme oxygenase (HO) and by the constitutive nitric oxide synthase (cNOS) protect circulation. In contrast, the enhanced level of the matrix metalloproteinase (MMP) augments cardiovascular risks. We examined the actions of recreational physical exercise on the expression of these enzyme systems in conjunction with cardiovascular prote...
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ea0026p582 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Heme-oxigenase mediates cardiovascular protection by oestrogen and raloxifene in menopause

Posa A , Varga C S , Berko A M , Veszelka M , Szabo R , Orban K , Pavo I , Laszlo F

Introduction: Selective oestrogen receptor modulators function as oestrogen receptor antagonist in the breast and gonads, while they have agonistic effects on the bone and the cardiovascular system. It is also known that endogenously produced carbon monoxide by the heme-oxigenase (HO) enzyme exerts beneficial actions in cardiovascular protection.Design: Intact females, ovariectomized (OVX), raloxifene or oestrogen treated OVX Wistar rats were used. We st...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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