Endocrine Abstracts (2011) 26 P108

Relation of insulin resistance and lipid peroxidation in non-obese women with polycystic ovary syndrome

D Macut1,2, A Lissounov2, I Bozic1, T Simic3, J Bjekic4, M Petakov1,2, S Damjanovic1,2 & A Savic-Radojevic3

1Institute of Endocrinology, Diabetes and Metabolic Disorders, Belgrade, Serbia; 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Faculty of Medicine, Institute of Biochemistry, University of Belgrade, Belgrade, Serbia; 4Department of Endocrinology, CHC Bezanijska kosa, Belgrade, Serbia.

Introduction: Polycystic ovary syndrome (PCOS) is a frequent metabolic disorder in women of the reproductive age, and is characterized by multi-factorial cardiovascular risk factors. Insulin resistance is proposed as a central factor linking PCOS to increasing risk of cardiovascular disease. The aim of our study was to explore a link between insulin resistance and oxidative stress, as a predictor of cardiovascular risk, in young, non-obese PCOS women.

Methods: A cross-sectional controlled study in 29 young PCOS women (age: 23.8±3.5 years; body mass index, BMI: 22.5±4.6 kg/m2) and 13 matched controls (age: 25.3±2.8 years; BMI: 20.6±3.3 kg/m2) was performed. Fasting blood samples were collected for the determination of malondialdehyde (MDA), glucose, insulin, testosterone, and sex hormone binding globulin. Insulin resistance was calculated using homeostasis assessment model (HOMA-IR).

Results: MDA concentrations showed no difference between PCOS and controls (4.0±1.6 vs 4.3±2.3 uM, P=0.685). Indices of insulin resistance were significantly higher in PCOS group in comparison to controls (insulin: 16.6±7.5 vs 10.7±2.6 mU/l, P=0.009; HOMA-IR: 3.2±1.3 vs 2.2±0.6, P=0.015). MDA had significant positive correlation with insulin (P=0.046) and HOMA-IR (P=0.016) in PCOS group only.

Conclusion: Our results indicate that insulin resistance could be responsible for increased level of oxidative stress in young, non-obese PCOS women. Presence of insulin resistance, hyperinsulinemia, and oxidative damage are likely to accelerate development of cardiovascular disease in PCOS women.

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