ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2011) 26 P666

Experience with the use of a real time continuous glucose monitoring system during the simultaneous pancreas kidney transplant in patients with diabetes

I González-Molero, M Domínguez-López, M S Ruiz de Adana, S González-Romero, M Gonzalo-Marín, S Valdes, G Olveira & F Soriguer

Endocrinology and Nutrition Service, Carlos Haya Hospital, Málaga, Spain.

Introduction: Simultaneous pancreas kidney transplant (SPK) is a prime line treatment option in patients with type 1 diabetes and chronic kidney failure. The glucose control during perioperatory period can be a prognostic factor for transplant. Actually, the utility of the continuous glucose monitoring is not well defined. Our objective was to study the utility of a continuous glucose monitoring system during the simultaneous pancreas kidney transplant.

Material and methods: We installed a real time continuous glucose monitoring system (Guardian, Medtronic) to patients transplanted the last 2 years in Carlos Haya Hospital. The system was maintained since 6–10 h before until 10–15 days after transplant. Capillary glucose controls were done (2–4/day) to calibrate the system. Alarms were programmed for hypo and hyperglycemia. The data aported by the system were used for the perioperatory glucose control and afterwards were discharged using carelink-pro1 program.

Results: Twenty patients received a simultaneous pancreas–kidney transplantation. The medium age was 38.08 (29–53) years and diabetes duration was 21.66 (17–28) years. 83.3% of the patients were in hemodialysis before the transplant (medium of time, 15.1 months). During the monitorization period, mean of capilar glucose was 127.9±34.8 mg/dl (median 121 mg/dl). Interstitial mean glucose from sensor was 127.3±32.2 mg/dl (median 124 mg/dl). A good correlation between capilar and interstitial glucose was observed (R=0.93, P<0.05).

AUC below 70 was 0.12±0.2 and AUC below 140 was 9.9±10.2.

Medical staff in operating room, intensive care and nephrology departments displayed good acceptance and satisfaction with the system. Principal advantages were: avoid doing capilar glicemias hourly and prevent hyper/hypoglycemias. Alarms played an important role in detecting hyperglycemia in these patients for an intensive early treatment.: Conclusions

Real time continuous monitoring could be an effective and useful tool for intensive glycemic control during peritransplant period with good correlation with capilar glucose data.

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