Searchable abstracts of presentations at key conferences in endocrinology
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13th European Congress of Endocrinology

Poster Presentations

Diabetes therapy

ea0026p660 | Diabetes therapy | ECE2011

Method of myocardial preconditioning during exercise tests in patients with type 2 diabetes mellitus after acute myocardial infarction

Chernyavskaya Tatiana , Meskhidze Ekaterina , Boravkov Igor

Patients type 2 diabetes mellitus and MI need multimodality treatment including, besides of drug therapy, non-drug approaches. Repeated Treadmil exercise test is open second window of preconditioning. Ischemic preconditioning limits infarct size in the heart, increase level of physical activity.Study aim: To study the effect of early started repeated Treadmil exercise tests in patients with type 2 diabetes mellitus and MI.Design: O...

ea0026p661 | Diabetes therapy | ECE2011

Effect of amino acid residues on N-terminal extension of GLP-1/IgG-Fc fusion protein

Lee C , Boyineni J , Chung H-S , Jang S-H

Glucagon-like peptide-1 (GLP-1) is an incretin hormone playing an important role in glucose-dependent insulin secretion and β-cell growth. However, GLP-1 is rapidly degraded by dipeptidyl peptidase IV (DPP-IV) in vivo. Many attempts have been made to develop long-acting GLP-1 analogs with chemical modification, amino acid substitution, and fusion protein technology. We previously showed that the N-terminal Ala- or Gly-extended GLP-1 and human immunoglobulin ...

ea0026p662 | Diabetes therapy | ECE2011

Evaluation of the global impact of incorporating a telemedicine system for type 1 diabetes patients with an insulin pump and real-time continuous glucose monitoring system

Gonzalez-Molero I , Dominguez-Lopez M , Guerrero M , Carreira M , Caballero F , Anarte M , Ruiz de Adana M S , Soriguer F

Introduction: Telehealth systems have become an alternative method to control chronic illnesses like diabetes. The aim of this study was to evaluate a telehealth system in patients with type 1 diabetes who have an optimized treatment with an insulin pump and real-time continuous glucose monitoring system.Research design and methods: Prospective, 1-year study of 15 patients with a continuous insulin infusion system and a real time glucose sensor. Three me...

ea0026p663 | Diabetes therapy | ECE2011

Evaluation of adolescents type 1 diabetic patients after transition from paediatric to adult care

Dominguez-Lopez M , Gonzalez-Molero I , RuizdeAdana-Navas S , delPino A , Lopez J P , Fernandez J D , Olveira G , Soriguer F

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

ea0026p664 | Diabetes therapy | ECE2011

Clinical effectiveness of a bolus calculator in patients with type 1 diabetes mellitus treated with insulin pump

Dominguez-Lopez M , Gonzalez-Molero I , RuizdeAdana M , Guerrero M , Cardona I , Colomo N , Soriguer F

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...

ea0026p665 | Diabetes therapy | ECE2011

Evaluation of long term outcomes of intensive treatment with s.c. insulin infusion (CSII) in type 1 diabetic patients

Gonzalez-Molero I , Dominguez-Lopez M , Rubio E , Carreira M , Ruiz de Adana M S , Gonzalez-Romero S , Machado A , Soriguer F

Introduction: Several studies have shown that treatment with insulin pump is an effective therapy for selected type 1 diabetes. Nevertheless, most of them analyse results in short period of time. The objective of this study is to evaluate long term effects on quality of life (DQOL) and metabolic control of CSII.Material and methods: We did a longitudinal study of type 1 diabetic patients previously treated with multiple daily insulin (MDI) therapy who in...

ea0026p666 | Diabetes therapy | ECE2011

Experience with the use of a real time continuous glucose monitoring system during the simultaneous pancreas kidney transplant in patients with diabetes

Gonzalez-Molero I , Dominguez-Lopez M , Ruiz de Adana M S , Gonzalez-Romero S , Gonzalo-Marin M , Valdes S , Olveira G , Soriguer F

Introduction: Simultaneous pancreas kidney transplant (SPK) is a prime line treatment option in patients with type 1 diabetes and chronic kidney failure. The glucose control during perioperatory period can be a prognostic factor for transplant. Actually, the utility of the continuous glucose monitoring is not well defined. Our objective was to study the utility of a continuous glucose monitoring system during the simultaneous pancreas kidney transplant.M...

ea0026p667 | Diabetes therapy | ECE2011

Unacylated ghrelin improves insulin sensitivity in the early phase of obesity

Delhanty P J D , Huisman M , van den Berge I , Abribat T , Themmen A P N , van der Lely A J

In Europe more than 50 million adults are diabetic. Of these, 90–95% have type 2 diabetes (T2D). It is also recognized that an even larger population is insulin resistant and it is thought that treatment at this early phase of the metabolic syndrome may prevent the occurrence of overt diabetes and associated pathologies. We are in the process of developing unacylated ghrelin (UAG) analogues as therapeutics for T2D. Towards this goal, we have used a mouse protocol in which...

ea0026p668 | Diabetes therapy | ECE2011

Antihyperglycemic action of creatine compared to glibenclamide in type II diabetic patients

Lovrencic M Vucic , Znaor A , Poljicanin T , Rocic P , Weber D S , Rocic B

Possible involvement of creatine in the regulation of glycaemia in diabetic patients has been implicated.The aim of this study was to investigate the short-term effect of creatine on the glycaemic profile during standard meal in comparison to the oral sulfonylurea hypoglycaemic agent glibenclamide, in type II diabetic patients.In a 14-day simmetrically randomized crossover trial, recently detected type II diabetic patients received...

ea0026p669 | Diabetes therapy | ECE2011

Impact of a DPP4-inhibitor on liver and heart lipid content and cardiovascular risc in type 2 diabetic patients

Kosi L , Chmelik M , Trattnig S , Luger A , Kautzky-Willer A

Background: Increased liver and cardiac fat are common in patients with type 2 diabetes mellitus (T2DM) and associated with increased risc for liver fibrosis and cardiovascular events. The effect of a DPP-4 inhibitor vildagliptin on the fat content of the liver and heart has not been evaluated.Methods: A total of 40 patients, 20 males and 20 females, treated at our diabetes metabolic unit of the Medical University of Vienna with gliptins underwent magnet...

ea0026p670 | Diabetes therapy | ECE2011

Self-monitoring of blood glucose in type 2 diabetes mellitus: effect on glycemic control in non-insulin-treated patients

Madeo B , Scaltriti S , Romano S , Diazzi C , El Goch M , Granata A R M , Cavani E R , Carani C , Rochira V

Introduction: The efficacy of self monitoring of blood glucose (SBMG) on glycaemic control in non-insulin-treated (NIT) type-2-diabetes-mellitus (T2DM) is still controversial. In this paper we evaluated the influence of SMBG on glycaemic control in patients with T2DM with poor glycaemic control treated with oral antidiabetic agents.Methods: Thirty NIT-T2DM patients with poor glycaemic control and HbA1c>7% under treatment with oral hypoglycaemic agent...

ea0026p671 | Diabetes therapy | ECE2011

Insulin resistance of multiple metabolic pathways in patients with type 1 diabetes on long term continuous s.c. insulin infusion therapy

Donga E , van Dijk M , Hoogma R P L M , Corssmit E P M , Romijn J A

Objective: The aim of the present study was to determine whether insulin resistance is important in well controlled, uncomplicated patients with type 1 diabetes on long term CSII, compared to matched healthy controls.Research design and methods: We studied 8 patients (4 men and 4 women) with type 1 diabetes on stable continuous subcutaneous insulin pump therapy and 8 healthy controls, matched for age, gender and BMI. Insulin sensitivity was measured by h...

ea0026p672 | Diabetes therapy | ECE2011

Factors related with the adherence of physicians to diabetes guidelines in type 2 DM patients in Turkey

Satman I , Imamoglu S , Yilmaz C , ADMIRE Study Group

Background: Guidelines for management of diabetes mellitus (DM) provide standardization of care and treatment. National clinical practice guidelines on DM have been developed in 2006 by The Society of Endocrinology and Metabolism of Turkey and reviewed annually.Methods: One hundred and eighty physicians evaluated previous 12 months’ medical records of their type 2 DM patients with special emphasis on whether the patients were followed consistently w...

ea0026p673 | Diabetes therapy | ECE2011

Effects of estradiol+drospirenone on sexual function in postmenopausal women with type 2 diabetes mellitus

Pogorelova A S , Berketova T U , Ragozin A K

Introduction: Sexual dysfunction is more prevalent in postmenopausal women with diabetes mellitus.Objective: The aim of the study was to prospectively evaluate the effects of oral estradiol+drospirenone on sexual function in postmenopausal women with type 2 diabetes mellitus.Methods: The study included 86 postmenopausal women with type 2 diabetes mellitus who were randomized into two groups: 44 women received oral 17β-estradio...

ea0026p674 | Diabetes therapy | ECE2011

Effect of sitagliptin monotherapy on serum total ghrelin levels in type 2 diabetic patients

Oz Gul O , Kiyici S , Ersoy C , Cander S , Unal O K , Erturk E , Tuncel E , Imamoglu S

Background: Sitagliptin, unlike the some major antihyperglycaemic drugs, is not associated with weight gain and has neutral effects on body weight. It is unclear whether sitagliptin treatment alters serum ghrelin levels in people with type 2 diabetes. The aim of the present study was to assess the effect of sitagliptin on serum ghrelin levels in patients with type 2 diabetes mellitus.Methods: Forty-four type 2 diabetic subjects were randomly assigned to ...

ea0026p675 | Diabetes therapy | ECE2011

UK National Exenatide Guidelines (NICE:CG87) compared to clinical outcomes at a district general hospital's diabetes department

Hughes D , Butterworth H , Mahto R

Objectives: The aim of the audit was to determine how our current clinical practice differs from that of the national standard set out in the UK by NICE guidance CG87 in regards to the use of exenatide.Material and methods: We measured weight and HbA1c at baseline and then again at 6 months from the date exenatide was started. The UK NICE guidelines recommends exenatide should only be considered in patients with a BMI≥35.0 kg/m2 with a H...

ea0026p676 | Diabetes therapy | ECE2011

Remission of diabetic nephropathy in type 2 diabetic Asian population: role of tight glucose and blood pressure control

Hsieh Y T , Hsieh M C , Tu S T

Background: Asian has higher prevalence of diabetic nephropathy and end-stage renal disease as compared to Caucasian. No study to date has evaluated whether multifactorial intervention was associated with remission of microalbuminuria in type 2 diabetic Asian population. We evaluated the effect of tightly controlling multiple factors on the remission of diabetic nephropathy in type 2 diabetic Chinese with microalbuminuria.Materials and methods: A total o...

ea0026p677 | Diabetes therapy | ECE2011

Comparative study of combination therapy between metformin plus thiazolinedione (TZD) and metformin plus DPP-4 inhibitor in type 2 diabetes

Kim Yonghyun , Shin Donghyun , Lee Eunjong

The pathogenesis of type 2 diabetes is explained by increment of insulin resistance and dysfunction of insulin secretion. If improvement of insulin resistance is not adequate in the early stage of diabetes especially in this country with more severe basal insulin secretion defect from the very beginning, diabetes rapidly progress to more aggressive stage with relative insulin deficiency. The most proper method of improving insulin resistance by prescription is metformin from t...

ea0026p678 | Diabetes therapy | ECE2011

Insulin analogue management: subjective and objective assessment of life quality in patients previously managed with human insulin

Gluvic Zoran , Rasic-Milutinovic Zorica , Tica Jelena , Lackovic Milena , Vujovic Marina , Popovic-Radinovic Vesna , Isenovic-Milivojevic Esma , Jankovic Jelena

Introduction: By using insulin analogue, it is expected to improve glycemic regulation in poorly controlled type 2 diabetes (t2DM). The aim of the study was to examine the quality of glycemic control and quality of life (QoL) of patients managed with insulin analogues, previously treated with human insulin.Materials and methods: The pilot study included 30 t2DM outpatients, divided into two groups (15 subjects) – the first group was treated with hum...

ea0026p679 | Diabetes therapy | ECE2011

Twelve months exenatide treament in type 2 diabetes and severe obesity

Felechosa M Dieguez , Rovira C Tuson , Ragnarsson C Sanchez , Alemany E Suarez-LLedo , Garcia L Cacho , Gallego N Valdes , Santiago J Prieto

Aim: To assess the effectiveness, safety and tolerability of Exenatide twice daily treatment of type 2 diabetes and obesity.Material and methods: Data analysis of obese type 2 diabetic patients initiated on Exenatide therapy in our Endocrine clinics who complete 1 year of treatment.Results: We included 42 patients, 30 women (71.4%) and 12 men (28.6%), mean (±S.D.) age 57±10 and 9±7 years diabetes evolu...

ea0026p680 | Diabetes therapy | ECE2011

New opportunity of treatment women with postmenopausal osteoporosis and diabetes mellitus type 2

Doskina Elena , Kochergina Irina , Ametov Alexander

Purpose of the study: Research dynamic of parameters of mineral metabolism, during 12 months therapy with Strontium ranelate (in dose – 2 g/day) at women with postmenopausal osteoporosis and diabetes type 2 (D2).Materials and methods: Forty-two women (age 65.9±3.2 years) in postmenopausal period with verified DM2 (DM2 longer from 1 to 12 years, all patients have standard on per oral therapy with ant diabetes drag – gliclazide, metformin or...

ea0026p681 | Diabetes therapy | ECE2011

Effects of lifestyle changes on incidents of type II diabetes in Tehran adult population

Ghanei Laleh , Azizi Fereidoun , Hadaegh Farzad

Introduction: Studies show that a change in lifestyle can prevent or delay progression to diabetes in those with glucose intolerance. This study aimed to survey the effects of lifestyle changes on incidents of type II diabetes in Tehran adult population.Materials and methods: This was a community based interventional study. Non-diabetic participants of Tehran Lipid and Glucose Study aged ≥20 years (6437 in control group and 2931 in intervention gro...

ea0026p682 | Diabetes therapy | ECE2011

The addition of acipimox in patients with type 2 diabetes with triglyceride level over 150 mg/dl in spite of fenofibrate therapy

Kim D-M , Park J R

Patients with type 2 diabetes have an increased risk of premature coronary heart disease (CHD). One of the underlying reasons for this increased risk is atherogenic dyslipidemia. Current management strategies focus on the initial use of statin or fibrate therapy (the latter approach indicated in patients with pronounced hypertriglyceridemia).American Diabetes Association recognizes serum triglycerides as a surrogate for atherogenic triglyceride-rich lipo...

ea0026p683 | Diabetes therapy | ECE2011

Monitoring thyroid function in diabetic patients on treatment with glucagon-like peptide 1 analog

Danciulescu R , Musat M , Rosca R , Cristescu V , Poiana C

Background and aims: Incretin mimetics are a new class of pharmacological agents with antihyperglycemic actions that mimic the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1. The thyroid gland exhibit a strong GLP-1 receptor expression in rodents but only low receptor levels in humans. GLP-1 receptors activation stimulates calcitonin secretion and promotes the development of C cell hyperplasia and medullary thyroid cancer in rodents....

ea0026p684 | Diabetes therapy | ECE2011

Impact of structured testing on level of glycemic control

Popovic-Pejicic S P P , Karlovic V K

Introduction: Clinical trials have show n that improved glycemic control reduces the incidence and progression of diabetes complications. One of the most important steps in diabetes treatment is to educate patients how to manage self monitorining blood glucose (SBGM) and adjust their life habits with their diabetes. A new diabetes management concept of structured testing is supported by Accu -Chek 360 View.Objectives: Assess the impact of structured test...

ea0026p685 | Diabetes therapy | ECE2011

Insulin therapy of diabetes mellitus type 2 and risk of development cardiovascular mortality

Ametov Alexander , Kochergina Irina , Doskina Elena , Ulanova Kermen

Purpose of work: Research influence of insulin therapy in the form of combine therapy with analogue of prolonged insulin – glargin and per oral anti diabetes treatment with (glibenclamide) on dynamics of risk of development of coronary (CHD) heart disease and death rate from cardiovascular disease (CVD) at diabetes mellitus type 2 (DM 2).Materials and methods: During the study was researched dynamic of risk of development CHD and death rate from CVD...