Endocrine Abstracts

Aim: To define the frequency of diabetic retinopathy course in type1 diabetes mellitus (T1DM) patients with and depression; to study the relation between depression and diabetic retinopathy severity.Materials and methods: One hundred and thirty-three T1DM patients aged 40.27±12.17 years (56 males and 77 females) without exacerbation of chronic and acute inflammatory diseases and verified mental disorders were included into the study. The duration of...

The prevalence of diabetes is increasing worldwide. According to the recent World Health Organization (WHO) estimates, more than 180 million people worldwide have diabetes. This number is likely to be more than the double by 2030. It is estimated that the developing countries will bear the brunt of diabetes epidemics in the 21st century. It is well known now that increased rates of other chronic diseases, such as hypertension, obesity, cardiovascular diseases are highly associ...

Introduction: Diabetes mellitus is equivalent of coronary artery disease (CAD), plenty of patients with CAD already has diabetes or prediabetes. Diabetes originate as result of interactions between diferent factors, like genetic and environment. The risk fatctors for type 2 diabetes are: positive family history for type 2 diabetes, obesity, age over 45 years, previous glucose intolerance or impaired fasting glucose, previous gestational diabetes or birthweight of children over...

Background: Endothelial dysfunction may have deleterious effect cardiovascular pathology in diabetic patients.Atrial natriuretic peptide (ANP) exerts beneficial effects on the cardiovascular system in part by exerting antioxidant activity. Recently it was reported that ANP is able to exert an antihypertrophic effect in myocitos at least in part due to inhibition of NADPH oxidase and superoxido generation.It seems that hyperglucemia...

Introduction: Type 2 diabetes mellitus (DM) is independent risk factors for micro and macrovascular disease. So, it has been associated with abnormalities of cardiac function and left ventricular hypertrophy (LVH). Type 2 diabetic individuals, particularly obese women, had higher heart rates, greater left ventricular wall thicknesses and greater cardiac mass than subjects without diabetes. The objective of the present study was to investigate association between waist circumfe...

Aim: To estimate QOL and intensity of depression symptoms in T1DM patients.Materials and methods: Total 53 T1DM patients (26m, 27f), mean age (M±σ) 33.6±2.7 years (20.00–54.00) and 35 of the control group (17m, 18f), mean age 34.8±2.9 years (22.00–50.00) were provided with the questionnaire of Medical Outcomes Study 36-Item Short-Form Health-Survey, Beck depression inventory and Test for estimation of subjective contr...

Research objective: To estimate interrelation of carbohydrate exchange compensation with indicators of blood lipids.Methods: Four hundred and seven patients suffering from diabetis of 1 and 2 types at the age of 47.20 (35.6325th–57.4275th) have been examined. The disease experience – 10.90 (6.4025th –18.4675th) years. All the examined patients have been divided into 3 groups. In the first group a...

Aim: To define impact of diabetic retinopathy as a risk factor at peoples with type 2 diabetes and diabetic foot.Material and methods: One hundred hospitalized patients with type 2 diabetes, screened for diabetic foot and diabetic retinopathy for 1 year. Clinical examination and laboratory investigations were evaluated.Results: From 100 patients, 53% were female and 47% male, duration of diabetes 10.47±4.77 years. Mean HbA1c w...

Introduction: Type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. To systematically analyse the relationship between androgen levels and T2DM by reviewing and meta-analyzing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was also performed.</...

Introduction: Purpose of this research was the study of peculiarities of early diabetic peripheral neuropathy (DPN) manifestations in patients with diabetes mellitus depending on diabetes manifestation age, indicators of antibody level of S100B.Description of methods: Sixty-two patients with diabetes mellitus (DM) at the age of 21.4 to 75.2 (the average age was 47.7±14.1 years) including 34 males (54.8%) and 28 females (45.2%) with longevity of DM m...

Introduction: Metformin improves hyperglycaemia via mechanisms which include activation of AMP-activated protein kinase (AMPK). Recent findings indicate that some metabolic actions of metformin occur also by AMPK-independent mechanisms.Objective: To study the action of metformin on expression of GLUT1 glucose transporter in rat models of severe and mild stretozotocin diabetes mellitus.Materials and methods: Severe diabetes mellitus...

DM is a major cause of blindness, cardio-vascular risk the highest in the diabetics. More than 40% of all trauma-unrelated lower extremity amputations are performed because of diabetic foot syndrome (DFS) and lower extremity gangrene, 35–40% of all deaths due to uremia fall to the diabetics.Aim: To study DM late complications prevalence and risk factors contributing to their progression.Materials and methods: A total of 1000 a...

Introduction: Major advances in the research and treatment of diabetes-related neuropathic phenomena are hampered due to its complicated pathophysiology and the scarcity of valid experimental models. The aim of this study was to establish novel systems facilitating monitoring and dissection of processes central to the development of diabetic neuropathy.Methods: In a non-invasive in vivo model, two-photon microscopy is used to detect and assess mec...

Introduction: Gilbert syndrome is one of the most common inherited diseases, with a prevalence of 5–7%. It is caused by a mutation in UGT1A1 gene, which is in turn responsible for a deficiency in bilirubin glucuronidation. It courses with unconjugated hyperbilirubinemia, and jaundice may occur in adolescence, after fasting, exercise, or in menses, and also with certain drugs. Individuals with Gilbert syndrome seem to have a reduction in the prevalence of micro- and macrov...

Diabetes mellitus disturbs cellular metabolism of all organs and systems, including myocardium. The disturbances in cardiomyocytes lead to changes of QT and QTc intervals prolongation. Research: to evaluate values of intervals QT and QTc in children with diabetes mellitus type 1 (DM1) and to reveal interrelation of the given changes with the duration of disease, age, sex, indices of metabolic control.Materials and methods: QT and QTc were evaluated on EC...

Aim: The aim of this study was to investigate the relationship between the clinical and laboratory findings of metabolic bone disease regarding the levels of osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa B ligand (RANKL) in the patients with diabetic nephropathy.Material and method: This study includes 61 type 2 diabetic patients and age-, sex-matched 20 healthy subjects. Diabetic patients were divided into three groups accordi...

Objective: Matrix γ-carboxyglutamate (Gla) protein (MGP) is a marker of athero-sclerosis reflecting the degree of inhibition of ongoing calcification processes in the vascular wall. Osteoprotegerin (OPG) and adiponectin (ADP) exerts anti-inflammatory and anti-atherosclerotic effects. We aimed at determining in type 2 diabetes patients the relationship between serum MGP, OPG, ADP levels and the HbA1c, HOMA insulin-sensitivity or B-cell function.Resea...

Introduction and aims: Diabetic neuropathy may trigger the development of anemia in patients even before the onset of advanced renal failure. Autonomic neuropathy with subsequent renal denervation, combined with damaged erythropoetin producing fibroblasts in renal cortex, may have contributed to the early development of anemia in the patients with diabetes. Proliferative retonopathy, autonomic neuropathy, microalbuminuria, and moderate renal failure, suggesting that, factors o...

Diabetic wounds represent a medical and economical burden with a high need to develop more efficient therapies.Estrogens have a positive effect on cutaneous wound healing. Their decreased levels could count for impaired wound healing in elderly. The biological estrogen’s effects are mediated by two nuclear receptors subtypes (ERα and ERβ) and they were differently implied for the wound healing benefic processes. However, the estrogen effec...

Objective: To examine association between diabetes properties (type, duration, treatment regiment etc.) and risk of any fracture in diabetic population.Methods: We analyzed local trauma clinic data for 3 sequential years from 2662 diabetic persons who were entered The National Register of diabetes mellitus patients (133 subjects with type 1 diabetes mellitus (T1DM) and 1995 ones with T2DM).Results: Fracture risk was higher in T1DM ...

Introduction: According to American Medical Association Health literacy means a group of skills, including reading and basic math skills that allow smooth functioning in the health care system. Despite the universality of schools in Europe, the problem of secondary or functional illiteracy did not only exist but seems to be growing. This is also a great ethical problem, because the illiteracy makes, e.g. fictive so basic patients right as informed consent. The reasons for this...

This work aimed at gathering own data on adrenal response to low-dose Synacthen test, CRH test and about periferal metabolism of cortisol in autoimmune type 1 diabetics with onset in adults. Seventy diabetics were investigated; age 44±10 years (mean±S.D.), age at diagnosis 28.5±10 years, disease duration 15±8 years, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%. The study was approved by the Ethical Committee. Adrenal reserve was t...

Background: Oxytocin is a nonapeptide hormone synthesized in the supraoptic and paraventricular nuclei of the hypothalamus. Oxytocin has an effect on uterine smooth muscle contraction, blood pressure, memory, learning capability, nursing, sexual and feeding behavior. Oxytocin and vasopressin stimulate the release of insulin and glucagon from the rat pancreas. Multi organelle effects of oxytocin make it as important hormone in body.Objective: The aim of t...