Endocrine Abstracts

Introduction: Purpose of this research was the study of peculiarities of early diabetic peripheral neuropathy (DPN) manifestations in patients with diabetes mellitus depending on diabetes manifestation age, indicators of antibody level of S100B.

Description of methods: Sixty-two patients with diabetes mellitus (DM) at the age of 21.4 to 75.2 (the average age was 47.7±14.1 years) including 34 males (54.8%) and 28 females (45.2%) with longevity of DM more than 1 year (disease duration is 13.2±8.4 years) were examined. S100B-antibodies were determined with use of CanAg S100 EIA reactive (CanAg Diagnostics AB, Sweden). The average value for the control group (N=30) was 54.00±15.60 ng/l. The laboratory data were presented in the form of mean±S.D., nonparametric – median, 25th and 75th percentiles.

Results: The patients were divided into 4 groups by the disease manifestation age. The first group was represented by the patients with DM manifestation age before 14 years (9 individuals), the second group was composed of patients with disease manifestation age 14–20 years (14 individuals), the third group was represented by the patients with manifestation age 20–30 years (16 individuals), the fourth group was composed of patients with disease manifestation age after 40 years (23 individuals). DM longevity in patients fallen ill before 14 years was significantly higher (Me=20.17 (12.00; 23.50)) versus disease longevity in patients fallen ill after 40 years (Me=10.00 (6.00; 15.00)); (U=122.50; P=0.02). In spite of the smaller disease longevity, the S100B level in patients fallen ill after 40 years was significantly higher (Me=31.11 (26.94; 35.03)) versus patients fallen ill before 14 years (Me=24.00 (21.06; 30.37)); (U=60.50; P=0.04).

Conclusion: The additional early laboratory predictor of DPN in patients at the age of 40 years regardless disease longevity is the increased level of S100B.