ECE2011 Poster Presentations Diabetes (epidemiology, pathophysiology) (32 abstracts)
Vaspin circulating levels in severely obese women with type 2 diabetes mellitus (T2DM): early changes following restrictive bariatric surgery
I Kyrou 1 , M Fried 2 , P Sramkova 2 , K Dolezalova 2 , O Bradnova 3 , V Hainer 3 , P McTernan 1 , S Kumar 1 & Jana Vrbikova 3
1University Hospital Coventry and Warwickshire, WISDEM, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK; 2OB Klinika, Prague, Czech Republic; 3Institute of Endocrinology, Prague, Czech Republic.
Introduction: Vaspin, identified as a novel insulin-sensitizing adipokine, is suggested to be dysregulated in T2DM patients with loss of association between circulating vaspin levels, BMI and insulin resistance (IR). The aim of this study was to examine whether restrictive bariatric surgery in severely obese women with T2DM leads to a realignment of vaspin and metabolic factors early following surgery and before complete resolution of diabetic status.
Methods/design: Therefore 9 women with T2DM and BMI>35 kg/m2 underwent restrictive bariatric surgery. Anthropometric and biochemical assessments were performed prospectively at baseline and 4 weeks post surgery. An age-matched control group of 13 non-diabetic women with BMI<25 kg/m2 was included in the study. (Data shown as mean±S.E.M.; P<0.05 was considered statistically significant).
Results: Circulating vaspin in controls correlated with HOMA-IR and fasting insulin (P<0.05), whereas vaspin serum levels in obese T2DM subjects did not correlate with IR indices and BMI. Obese T2DM subjects had almost fourfold higher circulating vaspin levels compared with controls (0.42±0.15 vs 0.11±0.03 ng/ml; P<0.01). One month post bariatric surgery vaspin decreased by 48% compared to baseline (post-op levels: 0.22±0.06 ng/ml, P<0.05); still twofold higher than controls. Obese T2DM women 4 weeks post surgery significantly reduced BMI, percent body fat, HOMA-IR, fasting insulin and fasting glucose (P<0.05), however vaspin remained uncorrelated with these post surgery reductions.
Conclusion: Despite a 48% reduction, circulating vaspin remained uncorrelated with fat loss and IR improvement in obese T2DM women early after restrictive bariatric surgery. Further studies need to examine whether vaspin regains correlative status at later time-points post bariatric surgery following T2DM resolution. Supported by EFSD New Horizons research grant.
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