Endocrine Abstracts (2011) 26 P327

Inflammatory T-lymphocyte proliferation in morbid obesity

K van der Weerd1, W A Dik1, B Schrijver1, D H Schweitzer2, A W Langerak1, R M Kiewiet1, M O van Aken1, J J M van Dongen1, A J van der Lelij1, F J T Staal1,3 & P M van Hagen1


1Erasmus MC, Rotterdam, The Netherlands; 2Reinier de Graaf Hospital, Delft, The Netherlands; 3LUMC, Leiden, The Netherlands.


Obesity is one of the leading causes of preventable death in the Western world, and its prevalence is dramatically increasing. Although obesity is primarily a metabolic disease, immunological aberrations also significantly contribute to obesity-related morbidity. The well-established state of chronic low-grade inflammation is considered to be crucial in the development of complications such as diabetes and atherosclerosis. Moreover, obesity is associated with increased susceptibility to infections, cancer and autoimmunity. Thus, disturbed immune regulation may exist in obese individuals. However, until now, a detailed description of systemic immunological changes in obesity is lacking.

We studied the effects of obesity on the T-cell compartment of morbid obese subjects. Blood was collected from eight morbid obese subjects and twenty lean control subjects. The T-cell compartment was defined phenotypically using flow cytometry and molecularly by T-cell receptor excision circle (TREC) analyses.

We found a selective increase in T-lymphocyte number in morbid obese subjects, which was mainly caused by an increase in CD4+ T-lymphocytes. Also, in morbid obese subjects TREC content was decreased in all T-lymphocyte subpopulations, demonstrating that the increase in T-lymphocytes is mainly caused by increased proliferation. Moreover, in morbid obese subjects we found increased plasma levels of IL-7 and CCL5, both potent enhancers of T-lymphocyte proliferation.

These data demonstrate that morbid obesity is associated with an increase in mainly CD4+ T-lymphocytes. Most likely, this is related to increased plasma levels of cytokines that stimulate T-lymphocyte proliferation. This increase in T-lymphocytes may contribute to the increased risk of autoimmunity and cancer described in morbid obesity.

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