Searchable abstracts of presentations at key conferences in endocrinology
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13th European Congress of Endocrinology

ea0026p302 | Obesity | ECE2011

Obesity in GDM

Ruas Luisa , Alves Marcia , Paiva Sandra , Marta Elvira , Lobo Antonio , Moura Paulo , Carvalheiro Manuela

Introduction: Retrospective study, 2003–07, of 619 GDM women.Patients and methods: Two groups according to pre-pregnancy BMI: Go ≥30, Gno <30 kg/m2. Influence of BMI in: family history of DM, previous GDM or macrossomia, gestational age at time of GDM diagnosis, weight gain, blood pressure, A1c, need and doses of Insulin, time and type of delivery, new- born weight, complications and re-evaluation post partum.<p class="abste...

ea0026p303 | Obesity | ECE2011

Obesity, metabolic syndrome, hepatic steatosis, fibrosis and viral load as negative factors affecting early (EVR) and sustained (SVR) virological response in patients with chronic hepatitis c treated with peginterferon and ribavirin

Tataru Abagiu M , Georgescu E F , Teodorescu R , Stanescu L

Our aim was to evaluate the impact of some clinical (obesity, metabolic syndrome), biochemical (HOMA-IR), histological (fibrosis, necroinflammation, steatosis) and viral factors (HCV viraemia) on both EVR and SVR in patients with genotype 1 chronic hepatitis C (CHC) treated with peginterferon plus ribavirin.Patients and methods: We evaluated retrospectively 188 naïve patients with CHC treated with peginterferon plus ribavirin at standard weight-base...

ea0026p304 | Obesity | ECE2011

Abstract withdrawn....

ea0026p305 | Obesity | ECE2011

Testosterone therapy increased muscle mass and lipid oxidation in ageing men

Frederiksen L , Hojlund K , Hougard D M , Brixen K , Andersen M

Background: The indication for testosterone therapy in ageing hypogonadal men without hypothalamic, pituitary or testicular disease remains to be elucidated. The aim of this study was to investigate the effect of testosterone therapy on insulin sensitivity, substrate metabolism, body composition and lipids in ageing men with relative hypogonadism using a predefined cut-off level for bioavailable testosterone.Methods: A randomized, double-blinded, placebo...

ea0026p306 | Obesity | ECE2011

Development and characterization of high-affinity leptins and leptin antagonists

Shpilman M , Niv-Spector L , Katz M , Varol C , Solomon G , Elinav E , Gertler A

Leptin is a pleiotropic hormone acting both centrally and peripherally. It participates in variety of biological processes including energy metabolism, reproduction and modulation of the immune response. So far structural elements affecting leptin binding to its receptor remain unknown. We employed random mutagenesis of leptin, followed by selection of high-affinity mutants by yeast-surface display and discovered that replacing residue D23 with a non-negatively charged amino a...

ea0026p307 | Obesity | ECE2011

Ghrelin effects on nutrition and digestion in pest insects

Peric Mataruga V , Mrdakovic M , Janac B , Vlahovic M , Mircic D , Ilijin L , Milosevic V

The gypsy moth, Lymantria dispar L., is one of the most destructive phytophagous pests of the northern hemisphere. It shows a tremendous capacity to increase in numbers, and feeds on a wide range of trees and shrubs. However, several different systems driving feeding behavior and digestion of Lymantria dispar L. have not yet been elucidated.Ghrelin along with several other hormones has significant effects on appetite and growth in humans an...

ea0026p308 | Obesity | ECE2011

TNFα plays an essential role in the downregulation of sex hormone-binding globulin production by decreasing hepatic HNF-4α through NF-κB activation

Barbosa-Desongles A , Simo R , Lecube A , Hernandez C , Selva D

The reason why obesity (a chronic low-grade inflammatory disease) is associated with low levels of sex hormone-binding globulin (SHBG) remains to be elucidated. In the present study we provide evidence that TNFα (a proinflammatory cytokine that increases with obesity) reduces SHBG production by human HepG2 hepatoblastoma cells. The effect of TNFα on human SHBG expression was mediated by NF-κB which causes the downregulation of HNF4α: a key SHBG transcriptio...

ea0026p309 | Obesity | ECE2011

Benzofran derivatives inhibit 11β-hydroxysteroid dehydrogenase type 1 in rodent adipose tissue

Kobayashi Y , Daisuke K , Yamaguchi Y , Ueda M , Miyata O , Tagawa N

Excess glucocorticoids (GC) promote visceral obesity, hyperlipidemia and insulin resistance. The main regulators of intracellular GC levels are 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive GC into bioactive forms such as cortisol in humans and corticosterone in rodents. Therefore, the inhibition of 11β-HSD1 has considerable therapeutic potential for metabolic diseases including obesity and diabetes. Benzofran is a key structure in ...

ea0026p310 | Obesity | ECE2011

Effect of dehydroepiandrosterone on 11β-hydroxysteroid dehydrogenase type 1 in rodent adipocytes

Tagawa N , Minamitani E , Kiyonaga D , Kobayashi Y

Dehydroepiandrosterone (DHEA) has been suggested to have an anti-obesity effect; however, the mechanism underlying this effect remains unclear. The effect of DHEA on adipocytes opposes that of glucocorticoids, which potentiate adipogenesis. The key to the intracellular activation of glucocorticoids in adipocytes is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which catalyses the production of active glucocorticoids (cortisol in humans and corticosterone in rod...

ea0026p311 | Obesity | ECE2011

Waist circumference is a better predictor of cardiovascular risk than body mass index in patients with type 2 diabetes mellitus

del Canizo-Gomez F J , Moreno-Ruiz I , Segura-Galindo A , de Gorospe C , Gonzalez-Losada T , Silveira Rodriguez B

There is a clear relationship between degree of obesity and abdominal obesity with the development of cardiovascular disease.Objective: To assess body mass index (BMI) and waist circumference (WC) as predictors of cardiovascular risk (CVR) in type 2 diabetes mellitus (T2DM) patients.Material and Methods: Cross-sectional study in 452 consecutive out-patients with T2DM who visited our clinic in Madrid, Spain for a routine follow-up. ...

ea0026p312 | Obesity | ECE2011

Effects of natural dietary antioxidants on insulin and IGF1 in obese patients with insulin resistance

Mancini A , Magini M , Festa R , Raimondo S , Silvestrini A , Pontecorvi A , Meucci E , Martorana GE

Oxidative stress (OS) could play an important role in metabolic syndrome (MS)-related manifestations contributing to insulin resistance (IR). The reciprocal influences between OS and IR are not clear. We investigated the effects of dietary antioxidants on IR, studying 24 obese (7 males and 17 females, 27–66 years), with IR evaluated by HOMA index, during treatment with metformin, comparing 2 dietary treatments: hypocaloric diet (group A, n=16) or a diet enriched wi...

ea0026p313 | Obesity | ECE2011

Envirometal and metabolic risk factors of obesity development in preschool children

Viazava L S , Solntsava A V , Sukalo A V , Dashkevich E I

Materials and methods: We investigated 79 normal (1st group) and 99 overweight (2nd group) preschool children. Deficient sport and average physical activity (APA) duration, risen appetite (point-assessment), prolonged television viewing and computer using time in children were considered as risk-factors of juvenile obesity manifestation. Height, weight, waist circumflex (WC) was measured; body mass index (BMI) was calculated. Serum leptin levels were detected by immunoenzyme m...

ea0026p314 | Obesity | ECE2011

Gender differences of leptin receptor gene genotypes and leptin levels in obese children

Solntsava A V , Aksionava E A , Danilenko N G , Viazava L S , Sukalo A V

Aim: To compare gender frequency of leptin receptor gene (LEPR) genotype rates and leptinemia levels in overweight children.Materials and methods: Three hundred children with adiposity were investigated (divided into groups: prepubertal (1st) m/f n=51/50, early pubertal (2nd) n=49/51, late pubertal (3d) n=50/49). 80 girls and 89 boys with obesity and 90 lean girls and 48 lean boys (control) were genotyped in 6 exon of LEPR gene (Q223...

ea0026p315 | Obesity | ECE2011

Testosterone and metabolic syndrome: a meta-analysis study

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Abersa Antonio , Tishova Yuliya , Saad Farid , Lenzi Andrea , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in MetS has not been completely clarified.To systematically analyse the relationship between androgen levels and MetS we performed a review and meta-analyses of available prospective and cross-sectional studies. A specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was als...

ea0026p316 | Obesity | ECE2011

Identification of a reliable biomarker for metabolic syndrome

Abdullah A R , Hasan H , Raigangar V

Introduction: Over the last decade there has been a steady rise in obesity and co-morbidity, but little is known about the rate of metabolic dysfunction among young adults in the United Arab Emirates. Various factors have been implicated as biomarkers of metabolic syndrome (MetS). The objective of this study was to analyze the relationships of various biomarkers (leptin, C-reactive protein (CRP), adiponectin, insulin, and uric acid) to the MetS components in lean, overweight, ...

ea0026p317 | Obesity | ECE2011

Serum Vitamin D and IGF1 levels in abdominal obesity women

Karonova T , Belyaeva O , Bazhenova E , Azzi D , Berezina A , Katysheva N , Galkina O , Micheeva E , Grineva E

Context: Decreased levels of both vitamin D and insulin-like growth factor 1 (IGF1) may be associated with obesity, however this had not been well established. We have examined the relationship of vitamin D status and circulating IGF1 with metabolic parameters in abdominal obesity women.Methods: Serum 25(OH)D and IGF1 levels were measured by means of ELISA in 90 women (mean age 45.6±4.3) with abdominal obesity (according to IDF criteria, 2005). Anth...

ea0026p318 | Obesity | ECE2011

Serum adiponectin levels in patients with type 1 gaucher disease

Petakov S , Suvajdzic N , Ognjanovic S , Isailovic T , Macut D , Djurovic M , Bozic I , Damjanovic S

Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of glucocerebrosidase with consequent massive acumulation of lipid-laden macrophages in various tissues. Estimated life expectancy is about 9 years shorter than for the reference population. Mortality due to macrovascular diseases is higher, and probably associated with metabolic abnormalities found in GD type 1 patients, including decreases in serum adiponectin levels. Because adip...

ea0026p319 | Obesity | ECE2011

Undiagnosed thyroid dysfunction, leptin and body mass index

Olaizola I , Granada M L , Julian M T , Castell C , Serra A , Alastrue A , Lucas A

Introduction: Leptin seems to be a major link between obesity and thyroid dysfunction.Design: To analyze the relationship between thyrotropin (TSH) and leptin (LP) plasma concentrations and body mass index (BMI), in 785 subjects (448 women) of 41.27±9.72 years and BMI 28.91±9.8 (18.04–93.98 kg/m2), without diagnosed thyroid disease or pregnancy, concentrations of TSH, free thyroxine (FT4), LP, glycemia and insulinemia...

ea0026p320 | Obesity | ECE2011

Low birth weight and obesity are associated with increased androgen levels among children with premature adrenarche

Lekka L , Kousta E , Anyfandakis K , Leka S , Papathanassiou A

Introduction: The aim of the study was to assess the impact of obesity and birth weight (BW) at diagnosis of premature adrenarche (PA) in a large cohort of greek children.Methods/design: We assessed clinical and laboratory characteristics of 221 children (175 girls and 46 boys) at diagnosis of PA.Results: At diagnosis of PA 149 children (67.4%) had pubic hair (Tanner stage ≥2), 10 (4.5%) had axillary hair (Tanner stage &#8805...

ea0026p321 | Obesity | ECE2011

Prevalence of metabolic syndrome in 850 obese children from infancy to adolescence

Bellone S , Prodam F , Ricotti R , Petri A , Agarla V , Guidi C , Genoni G , Bona G

Introduction: Obesity and connected metabolic alterations are a growing problem in paediatric age, but few data are available in the youngest population. Poor evidences on metabolic syndrome (MS) definition are present in childhood and the most used definitions are those of the modified National Cholesterol Education Program and of the International Diabetes Federation (IDF). Aim of our study was to evaluate the presence of MS in obese children using these two definitions and ...

ea0026p322 | Obesity | ECE2011

The effect of androgens on adipose tissue in PCOS

't Mannetje M , van Houten E L A F , McLuskey A , Kramer P , Themmen A P N , Visser J A

Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders of premenopausal women. It is also the most frequent cause of female infertility and affects 6.5–8% of women in their reproductive age. Two out of three criteria diagnoses PCOS: oligo- or anovulation, clinical or biochemical signs of hyperandrogenism and polycystic ovaries at ultrasound. In addition, PCOS women frequently display features of the metabolic syndrome, such as abdomin...

ea0026p323 | Obesity | ECE2011

Functional differences between visceral and subcutaneous fat pads originate in the adipose stem cell

Cantini G , Baglioni S , Francalanci M , Poli G , Borgogni E , Di Franco A , Squecco R , Francini F , Lucchese M , Perigli G , Serio M , Luconi M

Metabolic pathologies mainly originate from dysfunctions of the white adipose tissue (AT). Functional differences in AT and their impact on metabolism seem associated with the fat depot regional distribution, in particular the subcutaneous (SAT) and visceral (VAT) pads. Human adult adipose stem cell (ASC) populations have recently been characterized from SAT and VAT. In this study, using human ASC cultures obtained from paired biopsies of abdominal SAT, S-ASC, and VAT, V-ASC, ...

ea0026p324 | Obesity | ECE2011

Basal energy expenditure and fat mass changes in breast cancer patients

Tuncbilek Nermin , Guldiken Sibel , Soysal Atile Neslihan , Ekiz Bilir Betul , Koken Deniz

Aim: Basal energy expenditure (BEE), also called basal metabolic rate, increases in cancer patients and is thought to contribute to the weight loss observed in cancer cachexia. Cancer type, pathological stage and duration of disease influence BEE. The aim of this study was to evaluate BEE and body composition in breast cancer patients.Methods: Forty-three women with breast cancer whose received adjuvant chemotherapy and 80 healthy age and body mass index...

ea0026p325 | Obesity | ECE2011

Waist line radius to subcutaneous adipose tissue thickness- better insight to lipid stores centralisation

Ristic P , Bokunjic D , Andjelkovic Z

Introduction: It is well known fact that central lipid stores are related to glucose metabolism impairment. Standard anthropologic methods for measuring lipid stores centralisation are waist, waist to hip ratio and waist to height ratio. Still, often these markers fail to relate to difference in glucose metabolism between equally obese patients.Method: We analysed relation between waist line radius and subcutaneous adipose tissue thickness, determent wit...

ea0026p326 | Obesity | ECE2011

Serum leptin level and its association with body composition in obese children

Vishnevskaya M , Solnceva A

Body composition using dual energy X-ray absorptiometry (DEXA) can be used as an specific method for measuring fat mass and identify individual risk for cardiovascular and metabolic complications in obese children.Objective: To investigate serum leptin level and its relationship with fat distribution in obese children.Materials and methods: Eighty-seven children (male/female=43/44, mean age 12.81±0.5 years). obese (BMI>95 ...

ea0026p327 | Obesity | ECE2011

Inflammatory T-lymphocyte proliferation in morbid obesity

van der Weerd K , Dik W A , Schrijver B , Schweitzer D H , Langerak A W , Kiewiet R M , van Aken M O , van Dongen J J M , van der Lelij A J , Staal F J T , van Hagen P M

Obesity is one of the leading causes of preventable death in the Western world, and its prevalence is dramatically increasing. Although obesity is primarily a metabolic disease, immunological aberrations also significantly contribute to obesity-related morbidity. The well-established state of chronic low-grade inflammation is considered to be crucial in the development of complications such as diabetes and atherosclerosis. Moreover, obesity is associated with increased suscept...

ea0026p328 | Obesity | ECE2011

Letrozole normalizes serum testosterone but has no clinical effects in men with obesity-related hypogonadotropic hypogonadism

Loves S , de Jong J , van Sorge A , Telting D , Hermus A , de Boer H

Introduction: Hypogonadotropic hypogonadism is frequently observed in morbidly obese men, due to aromatase-dependent conversion of androgens to estrogens. The clinical impact of this sex hormone imbalance is unknown.Aim: Evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadism.Methods: Double-blind, placebo-controlled, 6-month trial in severely obese men (BMI>35 kg/m2) with obesity-relate...

ea0026p329 | Obesity | ECE2011

Small animal PET/CT imaging reveals altered in vivo insulin function in brown adipose tissue of obese mice

Quarta C , Bucci M , Colavita M , Fanti S , Obici S , Pasquali R , Iozzo P , Pagotto U

Brown adipose tissue (BAT) is an insulin sensitive organ having a very high uptake of glucose per gram of tissue. The role of insulin on glucose uptake in BAT is still poorly understood, moreover, it is not clear whether BAT insulin function is compromised with obesity. We used a small animal PET/CT imaging approach to analyse insulin function in vivo in lean and obese mice using a glucose analogue PET tracer (18F-FDG). Three groups of mice were analysed afte...

ea0026p330 | Obesity | ECE2011

Haematic circulating endocannabinoids (ECs) in lean, overweight and obese: the role of the gender

Fanelli F , Di Lallo V D , Belluomo I , Casadio E , Baccini M , Ibarra Gasparini D , Vicennati V , Pasquali R , Pagotto Uberto

A number of publications recently provided measurements of plasma ECs by liquid chromatography–tandem mass spectrometry (LC–MS/MS), however the reported circulating levels in normal subjects are scattered in a very wide range of concentrations. A quantitative LC–MS/MS method for anandamide (AEA), palmitoylethanolamide (PEA), oleoylethanolamyde (OEA) and 2arachidonoyl-glycerol (2AG), chromatographically resolved by its inactive isomer 1AG, was validated in house....

ea0026p331 | Obesity | ECE2011

Enhanced muscle mass by ALA treatment increase myostatin-mediated pathways in adipose tissue

Kwon H S , Hong O K , Lee S S , Kim S R , Yoo S J

Myostatin is expressed predominantly in skeletal muscle and at significantly lower levels in adipose tissue. The loss of myostatin by gene disruption prevents an age-related increase in adipose tissue mass and partially attenuates the obese and diabetic phenotypes. Inhibition of myostatin signaling could be useful to prevent and/or treat obesity and diabetes. Male OLETF and LETO rats as non-diabetic controls were treated with or without ALA (100 mg/kg per day) and/or insulin (...

ea0026p332 | Obesity | ECE2011

Effects of food, hormones and autonomic nervous activity on rhythmic expression of clock genes and metabolic genes in rat white adipose tissue

van der Spek R , Kervezee L , La Fleur S , Fliers E , Kalsbeek A

Background: Shift workers and rodents with clock gene mutations show increased risk of metabolic syndrome and type 2 diabetes (T2DM). Conversely, obesity and T2DM are related to circadian disturbances in humans and rodents. The circadian release of adipokines from white adipose tissue (WAT) plays a pivotal role in energy metabolism. Its regulatory mechanism is unclear at present.Aim: To determine the daily expression patterns of genes involved in circadi...

ea0026p333 | Obesity | ECE2011

Investigating the role of FTO in obesity: dysregulation of satiety signalling

McMurray F , Church C , Cox R D

In 2007 a genome wide association study linked SNPs in intron 1 of FTO with an increased body mass index. Individuals with the ‘risk’ allele are on average 3 kg heavier than those with the ‘protective’ allele. Furthermore, those with the ‘risk’ allele have demonstrated greater energy intake. Mouse models of FTO have been generated including a conditional overexpression allele of FTO, which has 2 additional copies of FTO (FTO-4). These mice have in...

ea0026p334 | Obesity | ECE2011

Synergistic post-prandial deregulation of orexigenic and anorexigenic systems in obesity

Gatta-Cherifi B , Mattias I , Vallee M , Tabarin A , Marsicano G , Piazza P V , Cota D

Introduction: Obese humans have increased plasma levels of endocannabinoids like anandamide (AEA) and 2-arachydonoyl-glycerol (2-AG). However, it is unknown whether these orexigenic signals have a role in human eating behavior.Design: We measured plasma AEA and 2-AG levels in 12 normal weight (10 F, age: 39.1±3.7 years, body mass index (BMI): 21.0±0.6 kg/m2, waist circumference (WC): 73.8±2.9 cm) and 12 insulin-resistant obese s...

ea0026p335 | Obesity | ECE2011

Long-term effects of normalization of testosterone on variables of the metabolic syndrome in hypogonadal men: the moscow study

Gooren L J , Kalinchenko S Y , Tishova Y A , Mskhalaya G J , Giltay E J , Saad F

Introduction: Men with the metabolic syndrome have low plasma testosterone (T) levels. We aimed to study whether normalization of plasma T in such men improved features of the metabolic syndrome over the longer term.Design/methods: 145 men, 35 to 70 years, with the metabolic syndrome and hypogonadism (baseline total testosterone level <12.0 nmol/l or calculated free T level <225 pmol/l). They had received treatment for 30 weeks with either parent...

ea0026p336 | Obesity | ECE2011

Therapy with exenatide in obese and morbidly obese type 2 diabetic patients: comparative analysis

Dieguez Felechosa M , Tuson Rovira C , Sanchez Ragnarsson C , Casal Alvarez F , Valdes Gallego N , Manjon Miguelez L , Prieto Santiago J

Aim: To compare the effectiveness and tolerability of Exenatide twice daily treatment of obese and morbidly obese type 2 diabetic (T2D) patients.Material and methods: To analyze data of obese and severe obese T2D patients initiated on Exenatide in our Endocrine clinics who complete one year of treatment. We separate patients in two groups: group A (BMI<40 kg/m2) and group B (BMI≥40 kg/m2). We did not include any modificati...

ea0026p337 | Obesity | ECE2011

Vitamin D and obesity

Kostoglou-Athanassiou I , Chronaiou A , Trianti V , Tagara S , Michou A , Liakopoulou A , Terzi T , Karfi A

Low vitamin D levels have been found in patients with diabetes mellitus type 2 and have been correlated with poor glycemic control. There are observations suggesting that vitamin D levels may be low in obesity.The aim was to study vitamin D levels in obese individuals.The levels of 25(OH)D3 were measured in 30 obese individuals aged 42.67 years (mean), range 27–64, BMI 35.49 (mean), range 30–46 and 37 control s...

ea0026p338 | Obesity | ECE2011

Glimepiride improves insulin sensitivity in oxidative skeletal muscle of obese rats: possible association between GLUT4 and SUR2A expressions

Felipe dos Santos Ferreira Marques M F S F M , Cristina Tieko Mori R C T M , Mitiko Okamoto M M O , Fabres Machado U F M

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...

ea0026p339 | Obesity | ECE2011

The relationship between adiposity and carbohydrate metabolism, by age and gender in Vlora, a city in Albania

Bilushi Yllka , Sinani Glodiana , Rrumbullaku Llukan

Objective study was to determine the prevalence of overweight, obesity, type 2 diabetes.Methods: The study in hospital of Vlora was carried out between January 2008 and Dicembre of 2009.The total study involved 284 patients, 167 women and 137 men, mean age 40–70 years whose height and body weight were evaluated.They were diagnosed with type 2 diabetes and were tested in addition to anthropometric evaluat...

ea0026p340 | Obesity | ECE2011

Long term low intensity recreational physical exercise attenuates colonic inflammation in rats: the role of heme oxygenase system

Szalai Z , Berko A M , Posa A , Szabo R , Orban K , Kiraly A , Laszlo F , Varga Cs

Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity ...

ea0026p341 | Obesity | ECE2011

Effects of Orexin-A on AMPK activity

Molnar A H , Kis G K , Varga C , Rakosi K , Scerif M , Laszlo F A , Laszlo F , Korbonits M

Introduction: The hypothalamic hormone orexin-A (OXA) increases food and water intake, regulates the sleep-wake cycle, muscle tone and energy balance. AMP-activated protein kinase (AMPK) is an important metabolic regulator with direct hypothalamic orexigenic and diverse peripheral effects including fat tissue and muscle.Aims: We aimed to study the influence of OXA on the activity of AMPK in the hypothalamus, subcutaneous and visceral adipose tissues, and...

ea0026p342 | Obesity | ECE2011

Monitoring the efficacy of long term low intensity physical exercise programmes by the laboratory and hormone profile of obesity

Berko A M , Kis G K , Szablics P , Kiss B , Orban K , Seres E , Varga Cs , Laszlo F

Introduction: In the human, obesity is one of the leading health problems as declared by the World Health Organization. Obesity is frequently associated with diabetes, hypertension and hyperlipaemia, these acts together as metabolic syndrome (MS). The risk of cardiovascular diseases is 5 to 10 times higher in MS. Lack of daily exercise is a good reason to evolve MS. Several hormones take part in the development of MS. Leptin and insulin, which are produced by the adipose tissu...

ea0026p343 | Obesity | ECE2011

3-iodothyronamine metabolism and metabolic effects in rat white adipocytes

Manni M E , Bigagli E , Saba A , Marchini M , Zucchi R , Raimondi L

Introduction: 3-Iodothyronamine (T1AM) is a novel thyroid hormone derivative, which has been detected in rat blood and tissues. In vivo, T1AM has been reported to produce several functional effects, including the switch of fuel utilization from carbohydrates to lipids. In the present work we used rat white adipocytes to investigate T1AM uptake, metabolism, and metabolic effects.Methods: Rat white adipocytes were incubated with exogenous T1AM. The ...

ea0026p344 | Obesity | ECE2011

The modulation of brain derived neurotrophic factor (bdnf) during exercise in obesity

Arafat A M , Brunelli A , Budde H , Adamidou A , Spranger J , Mohlig M , Pfeiffer A F H

Objectives: Brain Derived Neurotrophic Factor (BDNF) plays a fundamental role in regulation of metabolism and energy homeostasis. Low BDNF levels have been identified as possible biological causes for development of obesity and BDNF administration has been shown to induce weight loss and to improve insulin sensitivity in diabetic animal models. Acute exercise is known to induce a transient increase of peripheral BDNF but no information is yet available regarding the exercise-i...

ea0026p345 | Obesity | ECE2011

The modulation of atrial natriuretic peptide levels during exercise in obesity

Adamidou A , Mohlig M , Pfeiffer A F H , Arafat A M

Objectives: Growing interest has been focused on the role of atrial natriuretic peptide (ANP) in the protection of cardiac and vascular integrity. Moreover, ANP enhances lipolysis and fat-oxidation. However, the impact of exercise on ANP in obesity is not yet investigated. The aim of this study was to evaluate the modulation of exercise-induced changes in ANP in obesity.Methods: We studied the hormonal and metabolic responses to 30 min exercise on cyclo-...

ea0026p346 | Obesity | ECE2011

AM251, a CB1 receptor antagonist, increases GLUT4 expression in adipocytes

Furuya D T , Poletto A C , Freitas H S , Machado U F

Evidences have suggested that the endocannabinoid system is overactive in obesity, resulting in enhanced endocannabinoid levels in both circulation and visceral adipose tissue. The cannabinoid CB1 receptor is expressed in the adipose tissue besides the brain. Few studies in vitro suggest that CB1 activation increases glucose uptake in adipocytes. The objective of the present study was to investigate the CB1 receptor modulation on glucose transporter GLUT4 expression, which is ...

ea0026p347 | Obesity | ECE2011

Serum homocysteine levels in patients with nonalcoholic fatty liver disease

Polyzos S A , Kountouras J , Patsiaoura K , Katsiki E , Zafeiriadou E , Deretzi G , Zavos C , Gavalas E , Mane V , Slavakis A

Introduction: High serum homocysteine (Hcy) has been associated with insulin resistance (IR) syndrome and cardiovascular risk, although controversy exists. Nonalcoholic fatty liver disease (NAFLD) is regarded as the hepatic component of IR syndrome, but data on Hcy are limited. The aim of this cross-sectional study was to evaluate serum Hcy levels in patients with NAFLD.Methods: Thirty-one consecutive patients (54±11years, 8 males) with biopsy-prove...

ea0026p348 | Obesity | ECE2011

Body mass index, obesity and hyperuricemia in postmenopausal women

Povoroznyuk V , Dubetska G

Aim of research: To determine uric acid level in blood serum and incidents of hyperuricemia in postmenopausal women and their relation with body mass index (BMI).Object of research: Patients of clinic by the physiology and pathology of bone and joint disease department and Ukrainian medical-scientific center of osteoporosis: postmenopausal women (n=134). They were divided in the following groups depending on BMI: I group (BMI=20.0–24.9) &#150...