Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P382

ECE2011 Poster Presentations Thyroid (non cancer) (78 abstracts)

Evolution of thyroid function and antibodies in Hashimoto thyroiditis after 10 years observation. Study on 1000 patients

Dan Peretianu 1 , Mara Carsote 2 , Catalina Poiana 2 & Cristina Daniela Staicu 1

1Societatea Civila Medicala ‘Povernei’, Bucharest, Romania; 2Institute of Endocrinology, Bucharest, Romania.

Study: Retrospective, cohort.

Material and methods: A. Hashimoto thyroiditis (HT) diagnosis: i) antithyroperoxydase antibodies (ATPO) criteria; cut-off >34 IU/ml. ii) If ATPO=normal (N), HT was considered only antithyroglobuline antibodies (ATG) were >50 IU/ml (↑) and ultrasound was pattern 1 (pseudonodular, intense hypoechogenic, inhomogeneous – Peretianu, Endocrine Abstracts, 2007, 14, P340; 2008, 16, P772; 2009, 20, P79).

B. Patients: 1000 patients. HT: women: 950, men 5%.

Results: A. At the diagnostic moment (DiMo). i) Function: euthyroid (EUT): 460 (46%), hypothyroid (HOT): 397 (39%), hyperthyroid: 143 (15%) – from these: 95 (66%) associated certainly (TRAB+) Graves–Basedow disease (GBD). ii) ATPO: average: 620, S.D.: 1060. min: 1, max: 13 000. In 7 (0.7%), ATPO high, even no thyroid was detected. 28 with ATPO=N. iii) 26 (33%) HT with TRAB+ were EUT/HOT. iv) Amiodarone association: 14 (1.4%): 6 EUT, 4 HOT, 2 HIT.

B. Follow-up. i) Function: a. 15 (3.25%) with EUT became HOT after 0.2(!)-5 years (average=2.16, S.D.=1.72). b. 100% HOT remained HOT. c. HIT without treatment at 3 years become EUT in only 3, HOT in only 1. ii) ATPO: a. Evolutive type: undulatory: 118 (45%), decreasing: 34 (34%), increasing: 23 (56%). b. Linear correlation with thyroid hormone/ TSH: none; r=0.5/0.17, P=0.9 (NS).

Discussion: i) Ultrasound thyroid patterns. ii) ATPO histogramme by intervals. iii) Most common association in HT was GBD (see also Poiană, Endocrine Abstracts, 2008, 16, P7822).

Conclusions: i) HT presented more as EUT than HOT. ii) Only 2.5% EUT-HT become HOT, during first 5 years. iii) For searching new HOT, TSH at 3 months. iv) ATPO is not correlated to thyroid (function and morphology). v) No EUT-HT after 5 years modified function. vi) Amiodarone did not affect thyroid function. vii) HT-GBD is more difficult to control nonradically than GBD-no HT; if medical treatment, >3 years.

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