Endocrine Abstracts (2011) 26 P393

Study of the relation between subclinical hypothyroidism and diabetic complications

H Kameda1, S Nagai1, C Shimizu1,2, H Nomoto1, A Hirai1, K Kimachi1, K Y Cho1, A Nakagaki1, T Sawada1, T Kondo1, H Miyoshi1 & T Koike1


1Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan; 2Department of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.


Introduction: There were some studies on the relation between subclinical hypothyroidism and arteriosclerosis, but few studies between thyroid function and diabetic microangiopathy. This study was aimed at investigating the influence of subclinical hypothyroidism on diabetic complications in Japanese population.

Description of methods/design: We retrospectively surveyed a total of 106 type 2 diabetic patients with regard to thyroid function and microvascular complications. The patients were divided into two groups of subclinical hypothyroidism group (SCH group; TSH≥3 μU/ml), and euthyroid group(TSH<3 μU/ml). There were 16 patients of SCH group and 90 patients of euthyroid group.

Results: In the SCH group and euthyroid group, those with preproliferative and proliferative retinopathy were 5 (31.2%) and 10 patients (11.1%), overt nephropathy were 5 (31.2%) and 10 patients (11.1%), respectively. Those had neuropathy were each 14 patients (87.5%) and 46 patients (51.1%), respectively. The trends for the three diabetic complications were all significantly higher in the SCH group than euthyroid group (P=0.015, 0.015, 0.007). Serum TSH level was associated with greater prevalence of diabetic retinopathy in multiple logistic-regression analysis after an adjustment for age, duration of diabetes, HbA1c (OR 1.54, P=0.037).

Conclusion: Subclinical hypothyroidism contributes to development of diabetic microangiopathy.

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