Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P394

ECE2011 Poster Presentations Thyroid (non cancer) (78 abstracts)

Melatonin drug use in complex treatment of hypothyroidism manifest

Almagul Mansharipova , Gulnar Moldabek & Zhangentkhan Abylaiuly


Scientific Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan.

Aim: The aim of the study was to evaluate the clinical efficacy of melatonin in patients with hypothyroidism.

Materials and methods: In study were taken 51 patients from 25 to 63 years to manifest hypothyroidism (on a background of autoimmune thyroiditis), with anxiety-depressive syndrome and sleep disturbance. Thyroid hormones were determined by ELISA (Vector-Best Russia) Anxiety-depressive syndrome in patients with hypothyroidism were analyzed on hospital Anxiety and Depression Scale HADS. Patients were divided into 2 groups. First group with manifest hypothyroidism (25 patients) received standard replacement therapy with L-thyroxine and symptomatic therapy for 1 month. Second group with manifest hypothyroidism (26 patients) along with L-thyroxine and symptomatic therapy additionally received melatonin (15 mg/night) Statistical analysis was done by SPSS, to analyze the reliability of the Student T criteria.

Results: Thyroid hormones levels in the blood of patients with hypothyroidism group 1 and 2 before treatment showed no differences. With combination therapy of melatonin in group 2, serum TSH fell from the baseline to 82.2±1.5%, the level of free serum T4 increased from baseline to 56.8±2.4%, which differ from that of patients of group 1 after treatment. After the treatment, noted that in both groups there is significant reduction in anxiety, P<0.05, especially subclinical anxiety (P<0.05). Found that only after treatment of melatonin in the treatment of hypothyroidism is significantly reduced depressive states with 10.9±0.9 points to 6.9±0.5 points (P<0.05), with significantly reduced subclinical depression.

Conclusion: The inclusion of melatonin in the standard therapy for symptomatic hypothyroidism showed that the drug can affect the pituitary–thyroid system, removing anxiety and depression.

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