Endocrine Abstracts (2011) 26 P43

Evaluation of the incidence of disorders glycoregulation in some diseases endocrine

I Bistriceanu1, M E Preda1, M Bistriceanu2, L Putinelu3, S Bondari2, A Covei1, A Turcu2 & A Voican2

1Department of Endocrinology, Emergency Hospital, Craiova, Romania; 2Department of Endocrinology, University of Medicine and Pharmacy, Craiova, Romania; 3Department of Geriatry, Chronics Affections and Geriatric Hospital’s, Stefanesti Arges, Romania.

Glycoregulation disorders in endocrine are frequently, hormone excess or deficit resulting for impaired metabolism of glucose by different mechanisms.

Methods: The study was conducted on 118 patients with hyperthyroidism, acromegaly and hypercortisolism. The inclusion criteria were: patients nondiagnostics that have not followed the treatment with drugs that could induce hyperglycemia (epinephrine, oral contraceptives, glucocorticoids, mineralcorticoids etc.), no-collateral family history of diabetes mellitus. Making glucose tolerance test with 75 g glucose pulvis with glucose assessment at 1 and 2 h after glucose ingestion, allowed in varying proportions the detection of diabetes mellitus in the study.

Results: Glycoregulation disorders were present in 58% of hyperthyroidism, 46% of patients with acromegaly, 53% of those with hyipercortisolism. Altered carbohydrate metabolism was directly proportional to the excess hormone level, on the types of diseases studied.

Conclusions: Differential treatment specific endocrine disease, improves the disorder of glycoregulation occurred in the context of hormonal dysfunction.

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