Endocrine Abstracts (2011) 26 P550

The relation between metabolic syndrome and cognitive decline in elderly Turkish people

Sayid Shafi Zuhur, Berrin Karadag & Yuksel Altuntas

Endocrinology and Metabolism Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

Objective: To determine the relationship between metabolic syndrome (MS) and cognitive decline in people over 60 years age.

Methods: The age of the participants were between 60 and 89 years old (71.71±6.58). According to NCEP ATP III criteria 93 had MS and 47 had not. Cognitive performance was determined with the use of standardized mini mental test and the mini mental scores (MMS) of the two groups were compared. Apart from the MS we investigated the relationship between MMS and age, gender, educational status, tobacco and alcohol use, the history of acute myocardial infarction (AMI) and stroke, medication use (antihypertensive, insulin, oral antidiabetic, statin) and body mas index (BMI). Depression, which is a cause of pseudodementia, was also asessed with the use of geriatric depression scale (GDS).

Results: The MMS was low in 25 patients (26.9%) in the MS group, and in 7 subjects (14.9%) in the control group. We could not find difference between MMS’s of two groups statistically. In this study the MMS was low in subjectss with high fasting plasma glucose level, tobacco use, insulin use, advanced age and depression. The GDS’s of two groups were similar. There was not difference in the MMS’s between patients with high blood pressure, high triglyceride level, low HDL cholesterol level, history of AMI and stroke, low educational status, high BMI and in whom without them. We also could not find difference between MMS’s of the patients who use antihypertensives, oral antidiabetics and statins and in whom not using these medications.

Conclusion: The number of elderly people increases in Turkey, however, cognitive decline related to diseases also increases. The establishment of the risk factors, which affect the cognitive functions and prevention of them in elderly, would prevent the cognitive decline, one of the important causes of mortality and morbidity in today’s world.

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