Menopause is a physiological condition associated with an important change in the hormonal status, an adverse lipid profile and cardiovascular risk. Apolipoproteins are proteins that bind to lipids to transport them. Apolipoprotein intestine synthesis is regulated principally by the fat content of the diet, while in the liver by dietary composition, hormones, alcohol intake and lipid lowering drugs. Are they changed due to aging? Do they interfere in the hormonal changes?
The aim of the study was to evaluate apolipoprotein A1 and B100 values correlated to hormones in postmenopausal women compared with fertile women.
Subjects and methods: One hundred and forty-four postmenopausal, healthy women with a MMSE score over 28 and 170 fertile women were enrolled. Fasting blood samples were taken in order to determine the biochemical and hormonal status.
SPSS version 15 was used for statistical analyze.
Results: Postmenopausal women had higher mean values for BMI, waist circumference, triglycerides, total and LDL-cholesterol, apoliprotein A1 (P<0.001) and B 100(P=0.007), HOMA, cortisol, GHBP, IGFBP1, PTH and cross laps; lower mean values for fT3, T4, DHEA, DHEAS, ADION, PRL, GH, IGF1 and IGFBP3 compared with fertile women.
Apolipoprotein B correlated positively with BMI, waist circumference, triglycerides, total and LDL cholesterol, uric acid, GHBP (P<0.001) and negatively with DHEA (P<0.001), DHEAS (P=0.011), ADION (P=0.06), T4, fT4 (P<0.001) and IGFBP3 (P=0.034).
Apolipoprotein A correlated positively with HDL-cholesterol (P<0.001), apolipoprotein B (P=0.001) and negatively with estradiol (P=0.017), estrone (P=0.022), alkaline phosphatase, crosslaps (P=0.001) and osteocalcin (P=0.023).
Conclusion: Postmenopausal women have higher apolipoprotein B and surprisingly higher apolipoprotein A levels that correlate positively.
Their correlations with the hormonal status point to changes due to aging and joint action regarding cardiovascular risk.
30 Apr - 04 May 2011
European Society of Endocrinology