Endocrine Abstracts

Drug-induced Hyperprolactinaemia is commonly observed and frequently poses diagnostic and managerial difficulties. Clearly, it is important to ensure that there is no underlying pathological cause, such as a hypothalamic or pituitary tumour, which would need addressing separately. Anti-psychotic medications are a common cause of this condition, although this is not observed in some newer atypical antipsychotics. Other common causes include anti-depressants, anti-hypertensives,...

The true prevalence of clinically significant endocrine disease in HIV is difficult to get a handle on as the literature is in many cases Declaration of interesting or insufficiently illuminating. There is clearly potential for endocrine dysfunction, via many mechanisms including directly due to HIV, due to atypical infections and the drugs used to treat them, side effects of both prescribed and non-prescribed medications and structural pathology. Probably the best described e...

Severe or morbid obesity is becoming more common and now affects about 2% of the UK population. Neuroendocrine disturbances are a common feature of morbid obesity and include male and female hypogonadism, deficiencies of the GH-IGF-1 axis and features suggestive of Cushing’s syndrome in some patients. Patients with neuroendocrine disturbance can broadly be considered in three main categories: 1. Those with genetic syndromes (eg Prader-Willi syndrome, leptin deficiency, MC...

Endocrine management of the patient with coeliac disease (CD) can be divided between management of the long-term consequences of malabsorption and timely identification and treatment of associated autoimmune disorders. CD patients have chronic calcium and vitamin D malabsorption at diagnosis, leading to secondary hyperparathyroidism, which is frequently associated with hypocalcaemia, low BMD and osteopenia. In many cases these will improve following institution of a gluten-fre...

Androgen deprivation therapy (ADT) when used in the treatment of prostate carcinoma produces a severe state of hypogonadism. Several but not all epidemiological studies have reported that there is an increased incidence of cardiovascular disease (CVD) including myocardial infarction, life threatening arrhythmias, diabetes and sudden cardiac death (1). Studies have also shown that ADT causes adverse effects many within three months on several key cardiovascular risk factors. Th...

Abstract unavailable....