Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2012

Oral Communications

Reproduction and bone

ea0028oc2.1 | Reproduction and bone | SFEBES2012

The expression of kisspeptin and kisspeptin receptor is altered in pre-eclampsia

Williams Paula

Background: Kisspeptins (KISS1) and their receptor, KISS-1R, are expressed at higher levels in first trimester placental trophoblast cells than in term gestation. Expression is localised to the trophoblast compartment. In contrast to KISS1 which is only expressed in the villous trophoblast, KISS-1R is also found in the extravillous trophoblast population. Kisspeptins produced by first trimester trophoblast cells inhibited migration. Pre-eclampsia is known to be caused due to d...

ea0028oc2.2 | Reproduction and bone | SFEBES2012

Contrasting effects of kisspeptin-10 between men and women reveal sexual dimorphism in the hypothalamic regulation of human reproduction

Jayasena Channa , Nijher Gurjinder , Comninos Alexander , Abbara Ali , Januszewski Adam , Vaal Meriel , Sriskandarajah Labosshy , Murphy Kevin , Farzad Zohreh , Ghatei Mohammad , Bloom Stephen , Dhillo Waljit

Background: Genetic deficiency of the hypothalamic hormone kisspeptin, lead to pubertal failure and infertility. Kisspeptin is therefore a critical hypothalamic activator of reproduction. Kisspeptin-10 stimulates gonadotrophin release in both male and female rodents. However few studies have investigated the effects of kisspeptin-10 on gonadotrophin release in humans, and none have investigated its effects in women. If kisspeptin is to be useful for treating reproductive disea...

ea0028oc2.3 | Reproduction and bone | SFEBES2012

Kissorphin, a hexapeptide derivative of Kisspeptin, acts via Neuropeptide FF receptors to inhibit cyclic adenosine monophosphate release but has no Gonadotrophin-Releasing-Hormone releasing activity

Milton Nathaniel

Kisspeptin is a 54 amino acid peptide that stimulates Gonadotrophin-Releasing-Hormone (GnRH) release from the hypothalamus and consequently activates the Hypothalamic-Pituitary-Gonadal (HPG) axis. Recent studies have suggested that Kisspeptin also binds and activates Neuropeptide FF (NPFF) receptors. The C-terminal ten residues of Kisspeptin are capable of activation of both GnRH release and NPFF receptors. The aim of the current study was to determine which amino acids of Kis...

ea0028oc2.4 | Reproduction and bone | SFEBES2012

ERβ and GPR30 mediate distinct and opposite oestrogenic influences on microglial phagocytosis of apoptotic neuronal cells

Vohra Shiv , McArthur Simon , Solito Egle , Gillies Glenda

We have previously demonstrated that in experimental Parkinson’s disease local production of oestrogens protects against striatal dopamine loss in vivo (Gillies GE. et al. Pharmacol Biochem Behav. 2004;78:513–22). As neurodegenerative disease is invariably accompanied by neuroinflammation, much interest has focused on oestrogen receptor (ER)-dependent suppression of inflammatory activation of microglia, the primary innate immune cell-type in the brain, ...

ea0028oc2.5 | Reproduction and bone | SFEBES2012

Nutrient regulation of growth factor signalling in human placenta

Nadif Raja , Sykioti Vasia , Aplin John , Westwood Melissa

The in utero environment is crucial for both the prenatal and long-term health of the offspring. The placenta is able to modify its structure/function in response to maternal growth and nutritional signals to actively regulate maternal-to-fetus nutrient transfer and consequently optimum fetal development. Little is known about the molecular mechanisms involved in placental sensing of maternal nutrients. However, we postulate that nutrient flux through the hexosamine biosynthet...

ea0028oc2.6 | Reproduction and bone | SFEBES2012

Identification of microRNAs involved in regulating growth factor signalling in the first trimester placenta

Farrokhnia Farkhondeh , Westwood Melissa , Aplin John , Forbes Karen

Fetal growth restriction and overgrowth (macrosomia) are both associated with altered placental development and problems at birth. Both conditions have lifelong impacts on health including an increased risk of developing cardiovascular disease and diabetes. Placental development depends on co-ordinated cellular growth and is enhanced by maternally-derived growth factors. MicroRNAs (miRs) are known to regulate gene expression and we have shown that global miR suppression in pla...

ea0028oc2.7 | Reproduction and bone | SFEBES2012

Increased cardiovascular events in women with Polycystic Ovary Syndrome: retrospective analysis of a large database

Mani Hamidreza , Davies Melanie , Levy Miles , Blackledge Hanna , Gray Laura , Howlett Trevor , Khunti Kamlesh

Introduction: Women with PCOS share the underlying pathology of insulin resistance with diabetes, metabolic syndrome and have increased prevalence of obesity. Despite these well established risk factors data on long term cardiovascular outcomes are limited and conflicting.Methodology: Retrospective analysis of a multi-ethnic database of all women with PCOS attending one UK endocrine unit between 1988 and 2009. Cardiovascular (CV) events were identified b...

ea0028oc2.8 | Reproduction and bone | SFEBES2012

A calcium-sensing receptor (CaSR) variant, Glu250Lys, present in familial hypocalciuric hypercalcaemia (FHH) and autosomal dominant hypocalcaemic hypercalciuria (ADHH) probands represents a functionally neutral polymorphism: lessons for CaSR mutational analysis

Hannan Fadil , Nesbit M Andrew , Cranston Treena , Thakker Rajesh

Mutational analysis of the calcium-sensing receptor (CaSR) is frequently undertaken to confirm a diagnosis of familial hypocalciuric hypercalcaemia (FHH) and autosomal dominant hypocalcaemic hypercalciuria (ADHH). However, functional characterization of these CaSR mutations to demonstrate loss-of-function for FHH mutations and gain-of-function for ADHH mutations is infrequently performed. We demonstrate the importance of pursuing in vitro studies that investigate the functiona...