Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2012


Genetic regulation of pituitary tumorigenesis

ea0028s1.1 | Genetic regulation of pituitary tumorigenesis | SFEBES2012

Genetic models of pituitary disease in multiple endocrine neoplasia type 1 (MEN1)

Thakker Rajesh

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease characterised by the combined occurrence of parathyroid, pancreatic islet and anterior pituitary tumours. Over 60% of the anterior pituitary tumours in MEN1 patients are prolactinomas, ~25% are somatotrophinomas, ~5% are corticotrophinomas, and the remainder appear to be non-functioning. The MEN1 gene, a tumour suppressor, is located on chromosome 11q13, and more than 1300 MEN1 mutations, which are lik...

ea0028s1.2 | Genetic regulation of pituitary tumorigenesis | SFEBES2012

Modelling pituitary tumours in zebrafish

Liu Ning-Ai , Jiang Hong , Ben-Shlomo Anat , Wawrowsky Kolja , Fan Xue-Mo , Lin Shuo , Melmed Shlomo

The pituitary is highly sensitive to cell cycle disruptions. Although CDK gene mutations have not readily been identified in human pituitary tumors, overexpression of cyclins and dysregulation of CDK inhibitors are encountered in pituitary adenomas, indicating the importance of CDK activation for potential therapeutic targeting. However, it is difficult to predict which CDK inhibitor(s) may be effective against particular tumor types in vivo. Therefore, animal models fa...

ea0028s1.3 | Genetic regulation of pituitary tumorigenesis | SFEBES2012

A mouse model of paediatric craniopharyngioma

Martinez-Barbera Juan Pedro

Activating mutations in the gene encoding β-catenin have been identified in the paediatric form of human craniopharyngioma (adamantinomatous craniopharyngioma, ACP), an aggressive pituitary tumour accounting for up to 10% of paediatric intracranial tumours. Recently, we generated an ACP mouse model and revealed that, as in human ACP, nucleocytoplasmic accumulation of β-catenin (βcat-nc) and over-activation of the Wnt/β-catenin pathway occurs only in very fe...

ea0028s1.4 | Genetic regulation of pituitary tumorigenesis | SFEBES2012

Molecular signatures of pituitary tumours

Korbonits M

Pituitary adenomas are commonly occurring lesions, only some of which will result in clinically significant disease. The underlying molecular changes leading to monoclonal cell proliferation with self-limited growth in the majority of cases, and continuous growth in a small proportion, are currently unknown. While hormonal influences are clearly important additional factors, the primary abnormality will ultimately lead to up-regulation of the cell cycle machinery. Hormonal fee...