Endocrine Abstracts (2012) 28 P175

6q24 Transient Neonatal Diabetes Mellitus (TNDM)-16 years of data collection.

S Kabwama1, L Docherty1,3, E Cook1,2, L Harrison2, S Ellard4, S Ennis1, J Shield5, D Mackay1,3 & I Temple1,2

1Human Genetics & Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; 2Wessex Clinical Genetics Service, Princess Anne Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; 3Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury District Hospital, Salisbury, United Kingdom 4Institute of Biomedical and Clinical Science, Peninsular College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom 5Institute of Child Life and Health, University of Bristol, Bristol, United Kingdom.

Introduction: TNDM due to genetic aberrations at 6q24 is the commonest cause of diabetes presenting within the first week of life. TNDM predisposes to diabetes mellitus in later life. We report on the clinical presentation of the largest worldwide cohort of 6q24 TNDM cases.

Results: 164 cases were analysed. The mean age of presentation was 8 days with a mode of 1 day and maximum age of presentation of 90 days. On average, babies recovered by 4.5 months with a mode of 2 months. Birth weight had a normal distribution with a median of 1987g and ranges from 3370 g to 1050 g. Most babies in the study were born at term and only 13 babies were pre-term. 33.5% had paternally inherited duplications at 6q24, 29.3% had a maternal methylation mutation, and 37.2% had paternal UPD6. The data revealed a positive correlation between age of presentation and both birth weight and gestation (P=0.04 and P=0.007 respectively). No significant difference between the three genetic abnormalities (duplication, methylation and UPD6) in terms of age of presentation, remission, birth weight and gestation was observed. However, analysis of variance (ANOVA) identified a significant difference (P=0.016) between the groups in terms of birth weight corrected centile and this effect was most strongly observed when comparing babies carrying a methylation mutation against the other two groups combined (mean corrected centile 6.98 versus 1.91 respectively, P=0.005).

Conclusions: These results help define the clinical presentation of 6q24 TNDM. The data is consistent with larger babies having a later age of presentation- possibly due to bigger babies having more residual insulin. The results also indicate that TNDM due to methylation mutations is associated with a bigger birth weight than that seen with other genetic causes.

Declaration of interest: There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Funding: No specific grant from any funding agency in the public, commercial or not-for-profit sector.

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