Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology

Oral Communications

Obesity Clinical

ea0029oc12.1 | Obesity Clinical | ICEECE2012

Circulating endocannabinoids are associated to cardiometabolic alterations independently from adiposity

Fanelli F. , Mezzullo M. , Belluomo I. , Di Lallo V. , Colavita M. , Baccini M. , Casadio E. , Ibarra Gasparini D. , Vicennati V. , Pasquali R. , Pagotto U.

Obesity is characterized by an increase of endocannabinoid circulating levels as anandamide (AEA) and 2-arachidonoyl-glycerol (2AG). Whether these lipids represent a biomarker of dysmetabolism or merely reflect the fat mass spill-over is still unclear. After generating rigorous, gender specific, plasma reference intervals by 2D-liquid chromatography-tandem mass spectrometry, we defined the 97.5thcentile of endocannabinoid distribution in the normal population as the cut-off ab...

ea0029oc12.2 | Obesity Clinical | ICEECE2012

Lipid-induced insulin resistance is associated with a reduction of IGF1 bioactivity independent of changes in IGFBP-1 and -2 in humans

Arafat A. , Homssi S.v.G. , Weickert M. , Kraatz J. , Spranger J. , Frystyk J. , Pfeiffer A. , Mohlig M.

Objectives: Insulin interacts with the GH – insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...

ea0029oc12.3 | Obesity Clinical | ICEECE2012

The Young Investigator Winner

Stadler M. , Toman L. , Storka A. , Wolzt M. , Peric S. , Bieglmayer C. , Wagner O. , Pacini G. , Brath H. , Bech P. , Prager R. , Korbonits M.

Despite the known health hazards of cigarette smoking, many smokers fail to quit smoking, mainly due to nicotine’s addictiveness, but also because of fear from gaining weight. However, the mechanism of weight gain after smoking cessation is not fully elucidated yet.Healthy long-term smokers (28±2 years, 10F/20M, 23.4±1.3 kg/m2) participating in a smoking cessation programme underwent 3-hour oral glucose tolerance tests (oGTT) an...

ea0029oc12.4 | Obesity Clinical | ICEECE2012

Genetic susceptibility, birth weight and obesity risk in young chinese

Shi J. , Hong J. , Qi L. , Cui B. , Gu W. , Zhang Y. , Li L. , Xu M. , Wang L. , Zhai Y. , Miao L. , Wang R. , Bi Y. , Wang W. , Ning G.

Thus far, approximately 30 loci influencing body mass index (BMI) and the risk of obesity have been identified. In this study, we aimed to examine the individual and joint associations of 23 BMI-associated loci identified from recent genome-wide association studies in Caucasians with obesity risk in young Chinese. Birth weight reflects prenatal metabolic adaption and has been related to later-life obesity risk. We particularly assessed whether these genetic variants interacted...

ea0029oc12.5 | Obesity Clinical | ICEECE2012

Brown adipose tissue activation is inversely related with central obesity and metabolic parameters in adult human

Wang W. , Wang Q. , Zhang M. , Xu M. , Gu W. , Qi L. , Li B. , Ning G.

Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity and related metabolic risk. However, the supporting evidence in large population based studies is sparse.Methods: We studied 4011 (2688 males and 1323 females) tumor-free Chinese adults aged 18–89 for BAT activities, visceral/subcutaneous fat areas and metabolic parameters. In vivo 18F-fluorodeoxygluc...

ea0029oc12.6 | Obesity Clinical | ICEECE2012

Eating speed and the risk of type 2 diabetes mellitus: a case-control study

Radzeviciene L. , Ostrauskas R.

Introduction: Diabetes mellitus is one of the main public health issues. It is becoming a world pandemic. Type 2 diabetes appears to involve interaction between susceptible genetic backgrounds and environmental factors. It’s important to identify modifiable risk factors that may help reduce the risk of type 2 diabetes. For the meantime no data in scientific literature or eating speed could influence on the risk of developing type 2 diabetes mellitus. Therefore the aim of ...