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15th International & 14th European Congress of Endocrinology

Oral Communications

Thyroid Basic

ea0029oc15.1 | Thyroid Basic | ICEECE2012

PATZ1 is a new candidate tumour-suppressor gene in thyroid cancer

Chiappetta G. , Valentino T. , Vitiello M. , Pasquinelli R. , Monaco M. , Palma G. , Arra C. , Fusco A. , Fedele M.

Thyroid carcinoma arising from the thyroid follicular epithelium represents the most frequent endocrine malignancy and is mainly associated with gene rearrangements generating RET/PTC and TRK oncogenes, as well as BRAFV600E and RASV12 activating point mutations. Except for p53, which appears to be involved only in poorly differentiated and aggressive histotypes, a role of tumor-suppressor genes in the pathogenesis of thyroid cancer is still poorly known....

ea0029oc15.2 | Thyroid Basic | ICEECE2012

Ligand bound-thyroid hormone receptor contributes to reprogramming of pancreatic exocrine cells to insulin-producing cells via induction of Ngn3 and MafA

Furuya F. , Shimura H. , Endo T. , Kobayashi T.

Introduction: One goal of diabetic regenerative medicine is to instructively convert mature pancreatic exocrine cells into insulin-producing cells. We recently reported that liganded thyroid hormone receptor α (TRα) plays a critical role in expansion of the β-cell mass during postnatal development.Materials and Methods: AdTRα is a recombinant adenoviral vector that expresses human TRα1 under the control of the cytomegalovirus pro...

ea0029oc15.3 | Thyroid Basic | ICEECE2012

Radioiodine therapy of non-thyroidal cancer following systemic sodium iodide symporter (NIS) gene transfer using Transferrin-receptor (Tfr) targeted non-viral gene delivery vectors

Klutz K. , Grunwald G. , Willhauck M. , Schwenk N. , Vetter A. , Rodl W. , Hacker M. , Zach C. , Senekowitsch-Schmidtke R. , Wagner E. , Goke B. , Ogris M. , Spitzweg C.

We have recently demonstrated the high potential of non-viral polyplexes for tumor-specific delivery of the sodium iodide symporter (NIS) after systemic application. In the current study we used novel polymers based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the synthetic peptide B6 (LPEI-PEG-B6) as a transferrin (Tf)-receptor specific ligand to achieve active tumor targeting to human hepatocellular cancer (HuH7) cells after syst...

ea0029oc15.4 | Thyroid Basic | ICEECE2012

The DNA methylation as a predisposition factor in the pathogenesis of congenital hypothyroidism in premature infants

Marelli F. , Gentilini D. , Weber G. , Vigone M. , Radetti G. , Persani L.

Introduction: Epidemiological data indicate that children born prematurely have a risk 3–5 fold higher of congenital hypothyroidism (CH). In addition premature infants born small for gestational age (SGA) have a risk of 12% higher to develop IC compared to prematures with appropriate development (AGA). The mechanisms that justify the increased risk of IC are still unknown. Some studies report a pattern of aberrant methylation associated with prematurity, intrauterine feta...

ea0029oc15.5 | Thyroid Basic | ICEECE2012

The Young Investigator Winner

Janik J. , Strzyzewska-Jowko I. , Rudzinska M. , Czerwinska J. , Kiedrowski M. , Olszewski W. , Gornicka B. , Sowinski J. , Czarnocka B.

It is believed that differentiated thyroid tumors (DTC) metastasize via different pathways: papillary carcinoma (PTC) usually via lymphatic spread whereas follicular cancers (FTC) mainly hematogenously. However, the mechanism/s contributing to these tumors invasion is not fully understood.We examined the expression of lymphatic endothelial markers: Podoplanin (type-1 transmembrane mucin-like glycoprotein) and Prox1 (Prospero homeobox protein 1) in the PT...

ea0029oc15.6 | Thyroid Basic | ICEECE2012

Thyroglobulin induces thyroid cell growth through suppression of miR-16 and miR-195

Akama T. , Hara T. , Yan D. , Kawashima A. , Yoshihara A. , Sue M. , Tanigawa K. , Wu H. , Ishido Y. , Ishii N. , Suzuki K.

Introduction: Thyroglobulin (Tg) is stored in the follicular lumen of the thyroid and serves as a substrate of thyroid hormone biosynthesis. However, it was shown that Tg significantly induces thyrocyte cell growth and suppresses expression of thyroid-functional genes. Despite having such functions, molecular mechanisms of Tg action are largely unclear. We have recently demonstrated that TSH-induced thyroid cell growth is partly mediated by a downregulation of microRNAs (miRNA...