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15th International & 14th European Congress of Endocrinology

Plenary Lectures

Diabetes as a gut disease

ea0029pl7 | Diabetes as a gut disease | ICEECE2012

Diabetes as a gut disease

Nauck Michael A.

Gastric inhibitory polypeptide (GIP) is a physiologically important incretin hormone secreted from K cell of the upper small intestine. Glucagon-like peptide 1 (GLP-1) is secreted from L cells in the lower small and large intestine. Both hormones are released after nutrient (especially carbohydrate and fat) ingestion and glucose-dependently augment insulin secretion. An involvement of either incretin hormone in the pathogenesis of diabetes may, in principle, be related to abno...